Effects of Antibiotics on Gut Microbiota

Effects of Antibiotics on Gut Microbiota

The gut microbiota influences essential human functions including digestion, energy metabolism, and inflammation by modulating multiple endocrine, neural, and immune pathways of the host. Its composition and complexity varies markedly across individuals and across different sites of the gut, but pro...

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Veröffentlicht in:Digestive diseases (Basel) 2016-01, Vol.34 (3), p.260-268
Hauptverfasser: Lange, Kathleen, Buerger, Martin, Stallmach, Andreas, Bruns, Tony
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Disease Progression
Gastrointestinal Microbiome - drug effects
Humans
Review Article
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container_title Digestive diseases (Basel)
container_volume 34
creator Lange, Kathleen
Buerger, Martin
Stallmach, Andreas
Bruns, Tony
description The gut microbiota influences essential human functions including digestion, energy metabolism, and inflammation by modulating multiple endocrine, neural, and immune pathways of the host. Its composition and complexity varies markedly across individuals and across different sites of the gut, but provides a certain level of resilience against external perturbation. Short-term antibiotic treatment is able to shift the gut microbiota to long-term alternative dysbiotic states, which may promote the development and aggravation of disease. Common features of post-antibiotic dysbiosis include a loss of taxonomic and functional diversity combined with reduced colonization resistance against invading pathogens, which harbors the danger of antimicrobial resistance. This review summarizes the antibiotic-related changes of the gut microbiota and potential consequences in health and disease.
doi_str_mv 10.1159/000443360
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source Karger Journals; MEDLINE; Alma/SFX Local Collection
subjects Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Disease Progression
Gastrointestinal Microbiome - drug effects
Humans
Review Article
title Effects of Antibiotics on Gut Microbiota
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