Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis
Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studi...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2016-03, Vol.41 (1-2), p.109-122 |
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| container_title | Dementia and geriatric cognitive disorders |
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| creator | Kansal, Kalyani Mareddy, Manisha Sloane, Kelly L. Minc, Alexa A. Rabins, Peter V. McGready, John B. Onyike, Chiadi U. |
| description | Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions. |
| doi_str_mv | 10.1159/000443205 |
| format | Article |
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We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000443205</identifier><identifier>PMID: 26854827</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Advertising executives ; Aged ; Alzheimer Disease - mortality ; Alzheimer's disease ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - mortality ; Aphasia ; Comorbidity ; Dementia ; Development and progression ; Epidemiology ; Female ; Frontotemporal Dementia - mortality ; Genetic aspects ; Health aspects ; Humans ; Life expectancy ; Male ; Movement disorders ; Neurodegenerative diseases ; Phenotype ; Phenotypes ; Primary Progressive Nonfluent Aphasia - mortality ; Progressive supranuclear palsy ; Review Article ; Supranuclear Palsy, Progressive - mortality ; Survival Rate ; Systematic review ; Wernicke's aphasia</subject><ispartof>Dementia and geriatric cognitive disorders, 2016-03, Vol.41 (1-2), p.109-122</ispartof><rights>2016 S. Karger AG, Basel</rights><rights>2016 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2016 S. Karger AG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-60a4e58596fdb7ad71ceb51e7c4876977db33dc4e6e414e1658fa68c6537077c3</citedby><cites>FETCH-LOGICAL-c428t-60a4e58596fdb7ad71ceb51e7c4876977db33dc4e6e414e1658fa68c6537077c3</cites><orcidid>0000-0003-2255-4437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26854827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kansal, Kalyani</creatorcontrib><creatorcontrib>Mareddy, Manisha</creatorcontrib><creatorcontrib>Sloane, Kelly L.</creatorcontrib><creatorcontrib>Minc, Alexa A.</creatorcontrib><creatorcontrib>Rabins, Peter V.</creatorcontrib><creatorcontrib>McGready, John B.</creatorcontrib><creatorcontrib>Onyike, Chiadi U.</creatorcontrib><title>Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.</description><subject>Advertising executives</subject><subject>Aged</subject><subject>Alzheimer Disease - mortality</subject><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - mortality</subject><subject>Aphasia</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Frontotemporal Dementia - mortality</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Male</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Primary Progressive Nonfluent Aphasia - mortality</subject><subject>Progressive supranuclear palsy</subject><subject>Review Article</subject><subject>Supranuclear Palsy, Progressive - mortality</subject><subject>Survival Rate</subject><subject>Systematic review</subject><subject>Wernicke's aphasia</subject><issn>1420-8008</issn><issn>1421-9824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9r2zAUB3AxVpa266H3MQyD0h28SbZ-7lJM0nSDlg3anoViPzfubMuV5ED--6pzmsHYSQ_x4X0fX4ROCf5CCFNfMcaU5hlmb9AhoRlJlczo2z8zTiXGcoaOvH-MTDCu3qFZxiWjMhOH6OJ2dJtmY9qk6ZOls32wAbrBuvizgA760Jjk1xp6G7YD-G9JkdxAMGnRm3brG_8eHdSm9XCye4_R_fLybv49vf559WNeXKclzWRIOTYUmGSK19VKmEqQElaMgCipFFwJUa3yvCopcKCEAuFM1obLkrNcYCHK_BidT3sHZ59G8EF3jS-hbU0PdvSaCE65UrmQkX76hz7a0cV7o5IEUy6EYFGdTerBtKDXYNqw9rYdQ2N7rwumFGZZjI_w8wRLZ713UOvBNZ1xW02wfqlf7-uP9uMuelx1UO3la99_b_tt3AO4PVhc3kwr9FDVUX34r9qlPAM2YpFY</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Kansal, Kalyani</creator><creator>Mareddy, Manisha</creator><creator>Sloane, Kelly L.</creator><creator>Minc, Alexa A.</creator><creator>Rabins, Peter V.</creator><creator>McGready, John B.</creator><creator>Onyike, Chiadi U.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2255-4437</orcidid></search><sort><creationdate>20160301</creationdate><title>Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis</title><author>Kansal, Kalyani ; Mareddy, Manisha ; Sloane, Kelly L. ; Minc, Alexa A. ; Rabins, Peter V. ; McGready, John B. ; Onyike, Chiadi U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-60a4e58596fdb7ad71ceb51e7c4876977db33dc4e6e414e1658fa68c6537077c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Advertising executives</topic><topic>Aged</topic><topic>Alzheimer Disease - mortality</topic><topic>Alzheimer's disease</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - mortality</topic><topic>Aphasia</topic><topic>Comorbidity</topic><topic>Dementia</topic><topic>Development and progression</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Frontotemporal Dementia - mortality</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Life expectancy</topic><topic>Male</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Primary Progressive Nonfluent Aphasia - mortality</topic><topic>Progressive supranuclear palsy</topic><topic>Review Article</topic><topic>Supranuclear Palsy, Progressive - mortality</topic><topic>Survival Rate</topic><topic>Systematic review</topic><topic>Wernicke's aphasia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kansal, Kalyani</creatorcontrib><creatorcontrib>Mareddy, Manisha</creatorcontrib><creatorcontrib>Sloane, Kelly L.</creatorcontrib><creatorcontrib>Minc, Alexa A.</creatorcontrib><creatorcontrib>Rabins, Peter V.</creatorcontrib><creatorcontrib>McGready, John B.</creatorcontrib><creatorcontrib>Onyike, Chiadi U.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kansal, Kalyani</au><au>Mareddy, Manisha</au><au>Sloane, Kelly L.</au><au>Minc, Alexa A.</au><au>Rabins, Peter V.</au><au>McGready, John B.</au><au>Onyike, Chiadi U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>41</volume><issue>1-2</issue><spage>109</spage><epage>122</epage><pages>109-122</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>26854827</pmid><doi>10.1159/000443205</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2255-4437</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Dementia and geriatric cognitive disorders, 2016-03, Vol.41 (1-2), p.109-122 |
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| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Advertising executives Aged Alzheimer Disease - mortality Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - mortality Aphasia Comorbidity Dementia Development and progression Epidemiology Female Frontotemporal Dementia - mortality Genetic aspects Health aspects Humans Life expectancy Male Movement disorders Neurodegenerative diseases Phenotype Phenotypes Primary Progressive Nonfluent Aphasia - mortality Progressive supranuclear palsy Review Article Supranuclear Palsy, Progressive - mortality Survival Rate Systematic review Wernicke's aphasia |
| title | Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis |
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