Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature
Background: Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or...
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| Veröffentlicht in: | Dermatology (Basel) 2015-01, Vol.231 (4), p.312-318 |
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| container_title | Dermatology (Basel) |
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| creator | Masson Regnault, Marie Gadaud, Noémie Boulinguez, Serge Tournier, Emilie Lamant, Laurence Gladieff, Laurence Roche, Henri Guenounou, Sarah Recher, Christian Sibaud, Vincent |
| description | Background: Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin. Case Reports: We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review. Conclusion: Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required. |
| doi_str_mv | 10.1159/000439047 |
| format | Article |
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The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin. Case Reports: We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review. Conclusion: Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000439047</identifier><identifier>PMID: 26422424</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Carboplatin - adverse effects ; Case and Review ; Cyclophosphamide - adverse effects ; Cytarabine - adverse effects ; Dexamethasone - adverse effects ; Drug Eruptions - etiology ; Drug Eruptions - pathology ; Female ; Humans ; Hyperpigmentation - chemically induced ; Hyperpigmentation - pathology ; Idarubicin - adverse effects ; Lomustine - adverse effects ; Male ; Middle Aged ; Paclitaxel - adverse effects ; Vincristine - adverse effects</subject><ispartof>Dermatology (Basel), 2015-01, Vol.231 (4), p.312-318</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-a84cf311d61234ce3815971392f01f0f55168d5729ec31488af00a7e40d61da83</citedby><cites>FETCH-LOGICAL-c376t-a84cf311d61234ce3815971392f01f0f55168d5729ec31488af00a7e40d61da83</cites><orcidid>0000-0002-2625-0628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2427,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26422424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masson Regnault, Marie</creatorcontrib><creatorcontrib>Gadaud, Noémie</creatorcontrib><creatorcontrib>Boulinguez, Serge</creatorcontrib><creatorcontrib>Tournier, Emilie</creatorcontrib><creatorcontrib>Lamant, Laurence</creatorcontrib><creatorcontrib>Gladieff, Laurence</creatorcontrib><creatorcontrib>Roche, Henri</creatorcontrib><creatorcontrib>Guenounou, Sarah</creatorcontrib><creatorcontrib>Recher, Christian</creatorcontrib><creatorcontrib>Sibaud, Vincent</creatorcontrib><title>Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin. Case Reports: We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review. Conclusion: Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.</description><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Carboplatin - adverse effects</subject><subject>Case and Review</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cytarabine - adverse effects</subject><subject>Dexamethasone - adverse effects</subject><subject>Drug Eruptions - etiology</subject><subject>Drug Eruptions - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperpigmentation - chemically induced</subject><subject>Hyperpigmentation - pathology</subject><subject>Idarubicin - adverse effects</subject><subject>Lomustine - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Paclitaxel - adverse effects</subject><subject>Vincristine - adverse effects</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MFLwzAUBvAgipvTg3eRXD1U85K0Tb2Nok4YCFOPUmL7skXXtSSZsv_ejM2d3jv83gfvI-QS2C1AWtwxxqQomMyPyBAkh6RQgh_HnYFKVJalA3Lm_VdkXOXFKRnwTHIuuRySj3KBbRcW6HS_SWa41AEbOsNg6_V2p5NNj6638xZXQQfbre7pmJbaI31FZ9FTvdr6H4u_tDM0JtGpDTEurB2ekxOjlx4v9nNE3h8f3spJMn15ei7H06QWeRYSrWRtBECTAReyRqHiVzmIghsGhpk0hUw1ac4LrAVIpbRhTOcoWbxotBIjcrPLrV3nvUNT9c622m0qYNW2oupQUbTXO9uvP1tsDvK_kwiuduBbuzm6A9jf_wFfxmlL</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Masson Regnault, Marie</creator><creator>Gadaud, Noémie</creator><creator>Boulinguez, Serge</creator><creator>Tournier, Emilie</creator><creator>Lamant, Laurence</creator><creator>Gladieff, Laurence</creator><creator>Roche, Henri</creator><creator>Guenounou, Sarah</creator><creator>Recher, Christian</creator><creator>Sibaud, Vincent</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2625-0628</orcidid></search><sort><creationdate>20150101</creationdate><title>Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature</title><author>Masson Regnault, Marie ; 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The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin. Case Reports: We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review. Conclusion: Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.</abstract><cop>Basel, Switzerland</cop><pmid>26422424</pmid><doi>10.1159/000439047</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2625-0628</orcidid></addata></record> |
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| source | MEDLINE; Karger Journals |
| subjects | Aged Antineoplastic Agents - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Carboplatin - adverse effects Case and Review Cyclophosphamide - adverse effects Cytarabine - adverse effects Dexamethasone - adverse effects Drug Eruptions - etiology Drug Eruptions - pathology Female Humans Hyperpigmentation - chemically induced Hyperpigmentation - pathology Idarubicin - adverse effects Lomustine - adverse effects Male Middle Aged Paclitaxel - adverse effects Vincristine - adverse effects |
| title | Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature |
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