The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment
Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by dire...
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| Veröffentlicht in: | Cellular Physiology and Biochemistry 2016-01, Vol.38 (2), p.427-448 |
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| container_title | Cellular Physiology and Biochemistry |
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| creator | Gao, Yanping Feng, Bing Han, Siqi Zhang, Kai Chen, Jing Li, Chen Wang, Rui Chen, Longbang |
| description | Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications. |
| doi_str_mv | 10.1159/000438641 |
| format | Article |
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MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000438641</identifier><identifier>PMID: 26828359</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Cancer ; Cancer invasiveness ; Carcinogenesis - genetics ; Carcinogenesis - pathology ; Care and treatment ; Diagnosis ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Health aspects ; Humans ; Metastasis ; MicroRNA ; MicroRNAs - analysis ; MicroRNAs - genetics ; MicroRNAs - metabolism ; MiR-141 ; Neoplasm Metastasis - diagnosis ; Neoplasm Metastasis - genetics ; Neoplasm Metastasis - pathology ; Neoplasms - diagnosis ; Neoplasms - genetics ; Neoplasms - pathology ; Oncogenes ; Proliferation ; Review ; Signal Transduction</subject><ispartof>Cellular Physiology and Biochemistry, 2016-01, Vol.38 (2), p.427-448</ispartof><rights>2016 The Author(s) Published by S. Karger AG, Basel</rights><rights>2016 The Author(s) Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2016 S. Karger AG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-1a12d1c2fac9c0022ab67aa787d034f5488722bb2823165dbea7635830a131653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,2102,27635,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26828359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Yanping</creatorcontrib><creatorcontrib>Feng, Bing</creatorcontrib><creatorcontrib>Han, Siqi</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Chen, Longbang</creatorcontrib><title>The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment</title><title>Cellular Physiology and Biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications.</description><subject>Animals</subject><subject>Cancer</subject><subject>Cancer invasiveness</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - pathology</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs - analysis</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>MiR-141</subject><subject>Neoplasm Metastasis - diagnosis</subject><subject>Neoplasm Metastasis - genetics</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Oncogenes</subject><subject>Proliferation</subject><subject>Review</subject><subject>Signal Transduction</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNptkclv1DAUxiNERRc4cEfIEhc4pHiJl_Q2TOkilUXVcLZevAwuSTzYmUP_-7qk5FT5YL_Pv-_Ts19VvSX4lBDefsYYN0yJhryojkhDSd1KqV6WMya8Vq2Sh9Vxzne4lLKlr6pDKhRVjLdH1eXmt0O3sXcZRY--BZPi7fdVTRqCwoiu9gOMaA2jcSmfoYsUB3QeYDvGHDKaItokB9Pgxul1deChz-7N035S_br4ullf1Tc_Lq_Xq5vacKGmmgChlhjqwbQGY0qhExJAKmkxazxvlJKUdh1VlBHBbedACsYVw0AeBXZSXc-5NsKd3qUwQLrXEYL-J8S01ZCmYHqnVcc4owwwFrhxloDvmBQWt1458AxK1sc5a5fi373Lkx5CNq7vYXRxnzWRQnHBucIFPZ3RLZTkMPo4JTBlWTcEE0fnQ9FXgkle3iFYMXyaDeVDc07OL70SrB-HppehFfb9Ux_7bnB2If9PqQDvZuAPpK1LC7D4Pzx7vf75ZSb0znr2AObbobg</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Gao, Yanping</creator><creator>Feng, Bing</creator><creator>Han, Siqi</creator><creator>Zhang, Kai</creator><creator>Chen, Jing</creator><creator>Li, Chen</creator><creator>Wang, Rui</creator><creator>Chen, Longbang</creator><general>S. Karger AG</general><general>Cell Physiol Biochem Press GmbH & Co KG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20160101</creationdate><title>The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment</title><author>Gao, Yanping ; Feng, Bing ; Han, Siqi ; Zhang, Kai ; Chen, Jing ; Li, Chen ; Wang, Rui ; Chen, Longbang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-1a12d1c2fac9c0022ab67aa787d034f5488722bb2823165dbea7635830a131653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cancer invasiveness</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - pathology</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs - analysis</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>MiR-141</topic><topic>Neoplasm Metastasis - diagnosis</topic><topic>Neoplasm Metastasis - genetics</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - pathology</topic><topic>Oncogenes</topic><topic>Proliferation</topic><topic>Review</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Yanping</creatorcontrib><creatorcontrib>Feng, Bing</creatorcontrib><creatorcontrib>Han, Siqi</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Chen, Longbang</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cellular Physiology and Biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yanping</au><au>Feng, Bing</au><au>Han, Siqi</au><au>Zhang, Kai</au><au>Chen, Jing</au><au>Li, Chen</au><au>Wang, Rui</au><au>Chen, Longbang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment</atitle><jtitle>Cellular Physiology and Biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>38</volume><issue>2</issue><spage>427</spage><epage>448</epage><pages>427-448</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Karger Open Access; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cancer Cancer invasiveness Carcinogenesis - genetics Carcinogenesis - pathology Care and treatment Diagnosis Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Metastasis MicroRNA MicroRNAs - analysis MicroRNAs - genetics MicroRNAs - metabolism MiR-141 Neoplasm Metastasis - diagnosis Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology Oncogenes Proliferation Review Signal Transduction |
| title | The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment |
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