Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study
Background: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status. Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We pe...
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| Veröffentlicht in: | Dermatology (Basel) 2015-01, Vol.231 (2), p.119-126 |
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| creator | Miller, Iben Marie Johansen, Maria Egede Mogensen, Ulla B. Zarchi, Kian Ellervik, Christina Jemec, Gregor B.E. |
| description | Background: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status. Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]). Results: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432). Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected. |
| doi_str_mv | 10.1159/000430910 |
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Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]). Results: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432). Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000430910</identifier><identifier>PMID: 26138620</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Blood Coagulation ; Case-Control Studies ; Cross-Sectional Studies ; Denmark - epidemiology ; Epidemiology ; Female ; Hidradenitis Suppurativa - blood ; Hidradenitis Suppurativa - epidemiology ; Hospitals ; Humans ; Inflammation ; International Normalized Ratio ; Male ; Mean Platelet Volume ; Middle Aged ; Original Paper ; Partial Thromboplastin Time ; Platelet Count ; Severity of Illness Index ; Skin diseases ; Thrombocytopenia - blood ; Thrombocytopenia - epidemiology ; Thrombophilia - blood ; Thrombophilia - epidemiology ; Young Adult</subject><ispartof>Dermatology (Basel), 2015-01, Vol.231 (2), p.119-126</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>Copyright (c) 2015 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-b5aa929475fcb292ac7387461919b72e307a200b4445fb051fb1138e364d3ccc3</citedby><cites>FETCH-LOGICAL-c404t-b5aa929475fcb292ac7387461919b72e307a200b4445fb051fb1138e364d3ccc3</cites><orcidid>0000-0002-0712-2540</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26138620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Iben Marie</creatorcontrib><creatorcontrib>Johansen, Maria Egede</creatorcontrib><creatorcontrib>Mogensen, Ulla B.</creatorcontrib><creatorcontrib>Zarchi, Kian</creatorcontrib><creatorcontrib>Ellervik, Christina</creatorcontrib><creatorcontrib>Jemec, Gregor B.E.</creatorcontrib><title>Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status. Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]). Results: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432). Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Coagulation</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Denmark - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hidradenitis Suppurativa - blood</subject><subject>Hidradenitis Suppurativa - epidemiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>International Normalized Ratio</subject><subject>Male</subject><subject>Mean Platelet Volume</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Partial Thromboplastin Time</subject><subject>Platelet Count</subject><subject>Severity of Illness Index</subject><subject>Skin diseases</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - epidemiology</subject><subject>Thrombophilia - blood</subject><subject>Thrombophilia - epidemiology</subject><subject>Young Adult</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0TtPwzAQB3ALgWgpDOwIWWKBIeBXHmaD8ihSJZAKc3RxnOKSJsGOkfj2uLR0YPINv_vLd4fQMSWXlMbyihAiOJGU7KAhFYxGMuNsN9SEZlGWJPEAHTi3CIxlqdxHA5ZQniWMDNFy3MLc19CbtsGzHnrvsGnwxJQWSt2Y3jg8813nbSBfcI1v8B00xr3jl7bb9EUYmhJPWteZHuroFpwu8di2zkUzrVYC6pDty-9DtFdB7fTR5h2ht4f71_Ekmj4_Po1vppESRPRREQNIJkUaV6pgkoFKeZaKhEoqi5RpTlJghBRCiLgqSEyrgoaBNE9EyZVSfITO17mdbT-9dn2-NE7puoZGt97lNCWUSZkRGejZP7povQ0__lVhSZTzlbpYK7Uay-oq76xZgv3OKclXN8i3Nwj2dJPoi6Uut_Jv6QGcrMEH2Lm2W7Dp_wFmpYjN</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Miller, Iben Marie</creator><creator>Johansen, Maria Egede</creator><creator>Mogensen, Ulla B.</creator><creator>Zarchi, Kian</creator><creator>Ellervik, Christina</creator><creator>Jemec, Gregor B.E.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0712-2540</orcidid></search><sort><creationdate>20150101</creationdate><title>Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study</title><author>Miller, Iben Marie ; Johansen, Maria Egede ; Mogensen, Ulla B. ; Zarchi, Kian ; Ellervik, Christina ; Jemec, Gregor B.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-b5aa929475fcb292ac7387461919b72e307a200b4445fb051fb1138e364d3ccc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Coagulation</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Denmark - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hidradenitis Suppurativa - blood</topic><topic>Hidradenitis Suppurativa - epidemiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>International Normalized Ratio</topic><topic>Male</topic><topic>Mean Platelet Volume</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Partial Thromboplastin Time</topic><topic>Platelet Count</topic><topic>Severity of Illness Index</topic><topic>Skin diseases</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - epidemiology</topic><topic>Thrombophilia - blood</topic><topic>Thrombophilia - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Iben Marie</creatorcontrib><creatorcontrib>Johansen, Maria Egede</creatorcontrib><creatorcontrib>Mogensen, Ulla B.</creatorcontrib><creatorcontrib>Zarchi, Kian</creatorcontrib><creatorcontrib>Ellervik, Christina</creatorcontrib><creatorcontrib>Jemec, Gregor B.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Iben Marie</au><au>Johansen, Maria Egede</au><au>Mogensen, Ulla B.</au><au>Zarchi, Kian</au><au>Ellervik, Christina</au><au>Jemec, Gregor B.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>231</volume><issue>2</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status. Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]). Results: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432). Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>26138620</pmid><doi>10.1159/000430910</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0712-2540</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Blood Coagulation Case-Control Studies Cross-Sectional Studies Denmark - epidemiology Epidemiology Female Hidradenitis Suppurativa - blood Hidradenitis Suppurativa - epidemiology Hospitals Humans Inflammation International Normalized Ratio Male Mean Platelet Volume Middle Aged Original Paper Partial Thromboplastin Time Platelet Count Severity of Illness Index Skin diseases Thrombocytopenia - blood Thrombocytopenia - epidemiology Thrombophilia - blood Thrombophilia - epidemiology Young Adult |
| title | Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study |
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