Stimulation of Suicidal Erythrocyte Death by the Antimalarial Drug Mefloquine

Background: The antimalarial drug mefloquine has previously been shown to stimulate apoptosis of nucleated cells. Similar to apoptosis, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane with phosp...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.36 (4), p.1395-1405
Hauptverfasser:	Bissinger, Rosi, Barking, Susanne, Alzoubi, Kousi, Liu, Guilai, Liu, Guoxing, Lang, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology Apoptosis Apoptosis - drug effects Calcium Calcium - metabolism Cell Size - drug effects Cell volume Ceramides - metabolism Eryptosis Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Health aspects Humans Malaria Malaria - drug therapy Malaria - metabolism Mefloquine Mefloquine - pharmacology Original Paper Oxidative stress Oxidative Stress - drug effects Phosphatidylserine Physiological aspects Reactive Oxygen Species - metabolism ROS
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