Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Background/Aims: Evidence in multiple tissues, including retina, suggests generation of reactive oxygen species (ROS) and the ensuing oxidative stress as triggers for mitochondrial defects and cell apoptosis. We recently reported novel roles for Tiam1-Rac1-Nox2 axis in retinal mitochondrial dysfunct...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.36 (1), p.208-220
Hauptverfasser:	Veluthakal, Rajakrishnan, Kumar, Binit, Mohammad, Ghulam, Kowluru, Anjaneyulu, Kowluru, Renu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-bromopalmitate Aminoquinolines - pharmacology Animals Apoptosis Cattle Cells, Cultured Development and progression Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetic retinopathy Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Glucose - pharmacology Glucose metabolism Guanine Nucleotide Exchange Factors - metabolism Health aspects Lipoylation Male Mice Neuropeptides - metabolism Nox2 NSC23766 Original Paper p38 MAP kinase p38 Mitogen-Activated Protein Kinases - metabolism Palmitates - pharmacology Palmitoylation Pyrimidines - pharmacology Rac1 rac1 GTP-Binding Protein - metabolism Retina - drug effects Retina - metabolism Retina - pathology Retinopathy Signal Transduction - drug effects T-Lymphoma Invasion and Metastasis-inducing Protein 1 Tiam1 and Diabetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!