Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P 3 ) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of ce...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (4), p.1253-1275
Hauptverfasser:	Manna, Prasenjit, Jain, Sushil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular complications Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Care and treatment Cellular signal transduction Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Health aspects Humans Insulin Resistance Obesity Obesity - metabolism Obesity - pathology PH domain-containing proteins Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phosphoinositides PI3K/PTEN equilibria PtdIns(3,4,5)P3 PTEN Phosphohydrolase - metabolism Review Signal Transduction Vascular inflammation
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