Melatonin Protects the Esophageal Epithelial Barrier by Suppressing the Transcription, Expression and Activity of Myosin Light Chain Kinase Through ERK1/2 Signal Transduction

Background/Aims: Dilated intercellular space (DIS) contributes to the pathophysiology of gastroesophageal reflux disease (GERD). Melatonin protects the esophageal mucosa; however, the mechanisms underlying that protection remain unclear. Methods: Transmission electron microscopy (TEM) was used to ev...

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Veröffentlicht in:	Cellular physiology and biochemistry 2014-01, Vol.34 (6), p.2117-2127
Hauptverfasser:	Tan, Jiacheng, Wang, Ying, Xia, Yang, Zhang, Nina, Sun, Xiaomeng, Yu, Ting, Lin, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Epithelial Cells - drug effects Esophageal epithelial barrier Female Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - genetics Gastroesophageal Reflux - pathology Gene Expression Regulation - drug effects Humans Intestinal Mucosa - drug effects Male MAP Kinase Signaling System - drug effects Melatonin Melatonin - administration & dosage Middle Aged Myosin light chain kinase Myosin-Light-Chain Kinase - biosynthesis Myosin-Light-Chain Kinase - genetics Original Paper Tight Junctions - drug effects Tight Junctions - genetics Transcription, Genetic - drug effects
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