Water and Electrolyte Disorders at Long-Term Post-Treatment Follow-Up in Paediatric Patients with Suprasellar Tumours Include Unexpected Persistent Cerebral Salt-Wasting Syndrome
Background: Patients with brain tumours have a high risk of water and electrolyte disorders (WED). Postsurgery diabetes insipidus (DI) may be transient or permanent, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) are usually transient....
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| Veröffentlicht in: | Hormone research in paediatrics 2014-01, Vol.82 (6), p.364-371 |
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| creator | González Briceño, Laura Grill, Jacques Bourdeaut, Franck Doz, François Beltrand, Jacques Benabbad, Imane Brugières, Laurence Dufour, Christelle Valteau-Couanet, Dominique Guerrini-Rousseau, Léa Aerts, Isabelle Orbach, Daniel Alapetite, Claire Samara-Boustani, Dinane Pinto, Graziella Simon, Albane Touraine, Philippe Sainte-Rose, Christian Zerah, Michel Puget, Stéphanie Elie, Caroline Polak, Michel |
| description | Background: Patients with brain tumours have a high risk of water and electrolyte disorders (WED). Postsurgery diabetes insipidus (DI) may be transient or permanent, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) are usually transient. Methods: Retrospective study, including patients with suprasellar tumours, treated at Hôpital Necker, Institut Gustave-Roussy or Institut Curie, in Île-de-France, between 2007 and 2011. WED were noted if they persisted >1 month after surgery. Results: 159 patients were included, 54.1% girls, 43.9% boys. Tumour types were: glioma (43.4%), craniopharyngioma (43.4%), germinoma (11.3%), others (1.9%). Age at diagnosis was 7.1 ± 4.6 years. The median time from end of treatment was 1.9 (0-7.8) years. DI was the most frequent disorder after tumour treatment (50.3%) and was significantly associated with surgery (p < 0.001). Persistent CSWS was present in 3.6%, persistent SIADH in 1.3%. Two cases of hypernatraemia were due to adipsia. Thyrotropin deficiency after treatment was noted in 68.9% of patients tested, adrenocorticotropin deficiency in 66.2%. Conclusions: Patients with suprasellar tumours have a high incidence of long-term WED, mainly DI. Assessment of thyrotroph and corticotroph function, and thirst sensation, is necessary to diagnose and manage these disorders correctly. CSWS may be persistent in few patients and requires special attention to prescribe the appropriate care. |
| doi_str_mv | 10.1159/000368401 |
| format | Article |
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Postsurgery diabetes insipidus (DI) may be transient or permanent, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) are usually transient. Methods: Retrospective study, including patients with suprasellar tumours, treated at Hôpital Necker, Institut Gustave-Roussy or Institut Curie, in Île-de-France, between 2007 and 2011. WED were noted if they persisted >1 month after surgery. Results: 159 patients were included, 54.1% girls, 43.9% boys. Tumour types were: glioma (43.4%), craniopharyngioma (43.4%), germinoma (11.3%), others (1.9%). Age at diagnosis was 7.1 ± 4.6 years. The median time from end of treatment was 1.9 (0-7.8) years. DI was the most frequent disorder after tumour treatment (50.3%) and was significantly associated with surgery (p < 0.001). Persistent CSWS was present in 3.6%, persistent SIADH in 1.3%. Two cases of hypernatraemia were due to adipsia. Thyrotropin deficiency after treatment was noted in 68.9% of patients tested, adrenocorticotropin deficiency in 66.2%. Conclusions: Patients with suprasellar tumours have a high incidence of long-term WED, mainly DI. Assessment of thyrotroph and corticotroph function, and thirst sensation, is necessary to diagnose and manage these disorders correctly. CSWS may be persistent in few patients and requires special attention to prescribe the appropriate care.</description><identifier>ISSN: 1663-2818</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000368401</identifier><identifier>PMID: 25377653</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Brain Neoplasms - complications ; Brain Neoplasms - epidemiology ; Brain Neoplasms - therapy ; Child ; Child, Preschool ; Craniopharyngioma - complications ; Craniopharyngioma - epidemiology ; Craniopharyngioma - therapy ; Female ; Follow-Up Studies ; Glioma - complications ; Glioma - epidemiology ; Glioma - therapy ; Humans ; Inappropriate ADH Syndrome - epidemiology ; Inappropriate ADH Syndrome - etiology ; Incidence ; Infant ; Male ; Original Paper ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - epidemiology ; Postoperative Complications - epidemiology ; Retrospective Studies ; Wasting Syndrome - epidemiology ; Wasting Syndrome - etiology ; Water-Electrolyte Imbalance - epidemiology ; Water-Electrolyte Imbalance - etiology</subject><ispartof>Hormone research in paediatrics, 2014-01, Vol.82 (6), p.364-371</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>2014 S. Karger AG, Basel.</rights><rights>Copyright (c) 2015 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-3ec244c3a90d21ed8cfc538131156e336f18cba87e9c7d758b4bff5af2d20e0a3</citedby><cites>FETCH-LOGICAL-c439t-3ec244c3a90d21ed8cfc538131156e336f18cba87e9c7d758b4bff5af2d20e0a3</cites><orcidid>0000-0001-5993-8077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25377653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González Briceño, Laura</creatorcontrib><creatorcontrib>Grill, Jacques</creatorcontrib><creatorcontrib>Bourdeaut, Franck</creatorcontrib><creatorcontrib>Doz, François</creatorcontrib><creatorcontrib>Beltrand, Jacques</creatorcontrib><creatorcontrib>Benabbad, Imane</creatorcontrib><creatorcontrib>Brugières, Laurence</creatorcontrib><creatorcontrib>Dufour, Christelle</creatorcontrib><creatorcontrib>Valteau-Couanet, Dominique</creatorcontrib><creatorcontrib>Guerrini-Rousseau, Léa</creatorcontrib><creatorcontrib>Aerts, Isabelle</creatorcontrib><creatorcontrib>Orbach, Daniel</creatorcontrib><creatorcontrib>Alapetite, Claire</creatorcontrib><creatorcontrib>Samara-Boustani, Dinane</creatorcontrib><creatorcontrib>Pinto, Graziella</creatorcontrib><creatorcontrib>Simon, Albane</creatorcontrib><creatorcontrib>Touraine, Philippe</creatorcontrib><creatorcontrib>Sainte-Rose, Christian</creatorcontrib><creatorcontrib>Zerah, Michel</creatorcontrib><creatorcontrib>Puget, Stéphanie</creatorcontrib><creatorcontrib>Elie, Caroline</creatorcontrib><creatorcontrib>Polak, Michel</creatorcontrib><title>Water and Electrolyte Disorders at Long-Term Post-Treatment Follow-Up in Paediatric Patients with Suprasellar Tumours Include Unexpected Persistent Cerebral Salt-Wasting Syndrome</title><title>Hormone research in paediatrics</title><addtitle>Horm Res Paediatr</addtitle><description>Background: Patients with brain tumours have a high risk of water and electrolyte disorders (WED). Postsurgery diabetes insipidus (DI) may be transient or permanent, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) are usually transient. Methods: Retrospective study, including patients with suprasellar tumours, treated at Hôpital Necker, Institut Gustave-Roussy or Institut Curie, in Île-de-France, between 2007 and 2011. WED were noted if they persisted >1 month after surgery. Results: 159 patients were included, 54.1% girls, 43.9% boys. Tumour types were: glioma (43.4%), craniopharyngioma (43.4%), germinoma (11.3%), others (1.9%). Age at diagnosis was 7.1 ± 4.6 years. The median time from end of treatment was 1.9 (0-7.8) years. DI was the most frequent disorder after tumour treatment (50.3%) and was significantly associated with surgery (p < 0.001). Persistent CSWS was present in 3.6%, persistent SIADH in 1.3%. Two cases of hypernatraemia were due to adipsia. Thyrotropin deficiency after treatment was noted in 68.9% of patients tested, adrenocorticotropin deficiency in 66.2%. Conclusions: Patients with suprasellar tumours have a high incidence of long-term WED, mainly DI. Assessment of thyrotroph and corticotroph function, and thirst sensation, is necessary to diagnose and manage these disorders correctly. CSWS may be persistent in few patients and requires special attention to prescribe the appropriate care.</description><subject>Adolescent</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Craniopharyngioma - complications</subject><subject>Craniopharyngioma - epidemiology</subject><subject>Craniopharyngioma - therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glioma - complications</subject><subject>Glioma - epidemiology</subject><subject>Glioma - therapy</subject><subject>Humans</subject><subject>Inappropriate ADH Syndrome - epidemiology</subject><subject>Inappropriate ADH Syndrome - etiology</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Original Paper</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - epidemiology</subject><subject>Postoperative Complications - epidemiology</subject><subject>Retrospective Studies</subject><subject>Wasting Syndrome - epidemiology</subject><subject>Wasting Syndrome - etiology</subject><subject>Water-Electrolyte Imbalance - epidemiology</subject><subject>Water-Electrolyte Imbalance - etiology</subject><issn>1663-2818</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1vEzEQhlcIRKvSA3eELHGhhwV7vR_eIwptqRSJSEnU48qxZ4OL117GXpX8LX4hXiXkwGU8kp955-PNsreMfmKsaj9TSnktSspeZJesrnleiKJ-ec6ZuMiuQ3iiMyealjWvs4ui4k1TV_wy-_MoIyCRTpNbCyqit4cI5KsJHjVgIDKSpXf7fAM4kJUPMd8gyDiAi-TOW-uf8-1IjCMrCdrIiEalNJr0H8iziT_IehpRBrBWItlMg5-S6oNTdtJAtg5-j6ktaLJK3UyIs-4CEHYoLVlLG_NHGaJxe7I-OI1-gDfZq17aANen9yrb3t1uFt_y5ff7h8WXZa5K3sacgyrKUnHZUl0w0EL1quKC8XS1GjiveybUTooGWtXophK7ctf3lewLXVCgkl9lH4-6I_pfE4TYDSaoeQ8Hfgodq6tiPqOoEvrhP_QprenSdIkqBW_nkKibI6XQh4DQdyOaQeKhY7SbvezOXib2_Ulx2g2gz-Q_5xLw7gj8lLgHPAOn-r_CmaUn</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>González Briceño, Laura</creator><creator>Grill, Jacques</creator><creator>Bourdeaut, Franck</creator><creator>Doz, François</creator><creator>Beltrand, Jacques</creator><creator>Benabbad, Imane</creator><creator>Brugières, Laurence</creator><creator>Dufour, Christelle</creator><creator>Valteau-Couanet, Dominique</creator><creator>Guerrini-Rousseau, Léa</creator><creator>Aerts, Isabelle</creator><creator>Orbach, Daniel</creator><creator>Alapetite, Claire</creator><creator>Samara-Boustani, Dinane</creator><creator>Pinto, Graziella</creator><creator>Simon, Albane</creator><creator>Touraine, Philippe</creator><creator>Sainte-Rose, Christian</creator><creator>Zerah, Michel</creator><creator>Puget, Stéphanie</creator><creator>Elie, Caroline</creator><creator>Polak, Michel</creator><general>S. 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complications</topic><topic>Brain Neoplasms - epidemiology</topic><topic>Brain Neoplasms - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Craniopharyngioma - complications</topic><topic>Craniopharyngioma - epidemiology</topic><topic>Craniopharyngioma - therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glioma - complications</topic><topic>Glioma - epidemiology</topic><topic>Glioma - therapy</topic><topic>Humans</topic><topic>Inappropriate ADH Syndrome - epidemiology</topic><topic>Inappropriate ADH Syndrome - etiology</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Original Paper</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - epidemiology</topic><topic>Postoperative Complications - epidemiology</topic><topic>Retrospective Studies</topic><topic>Wasting Syndrome - epidemiology</topic><topic>Wasting Syndrome - etiology</topic><topic>Water-Electrolyte Imbalance - epidemiology</topic><topic>Water-Electrolyte Imbalance - 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Academic</collection><jtitle>Hormone research in paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González Briceño, Laura</au><au>Grill, Jacques</au><au>Bourdeaut, Franck</au><au>Doz, François</au><au>Beltrand, Jacques</au><au>Benabbad, Imane</au><au>Brugières, Laurence</au><au>Dufour, Christelle</au><au>Valteau-Couanet, Dominique</au><au>Guerrini-Rousseau, Léa</au><au>Aerts, Isabelle</au><au>Orbach, Daniel</au><au>Alapetite, Claire</au><au>Samara-Boustani, Dinane</au><au>Pinto, Graziella</au><au>Simon, Albane</au><au>Touraine, Philippe</au><au>Sainte-Rose, Christian</au><au>Zerah, Michel</au><au>Puget, Stéphanie</au><au>Elie, Caroline</au><au>Polak, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water and Electrolyte Disorders at Long-Term Post-Treatment Follow-Up in Paediatric Patients with Suprasellar Tumours Include Unexpected Persistent Cerebral Salt-Wasting Syndrome</atitle><jtitle>Hormone research in paediatrics</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>82</volume><issue>6</issue><spage>364</spage><epage>371</epage><pages>364-371</pages><issn>1663-2818</issn><eissn>1663-2826</eissn><abstract>Background: Patients with brain tumours have a high risk of water and electrolyte disorders (WED). Postsurgery diabetes insipidus (DI) may be transient or permanent, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) are usually transient. Methods: Retrospective study, including patients with suprasellar tumours, treated at Hôpital Necker, Institut Gustave-Roussy or Institut Curie, in Île-de-France, between 2007 and 2011. WED were noted if they persisted >1 month after surgery. Results: 159 patients were included, 54.1% girls, 43.9% boys. Tumour types were: glioma (43.4%), craniopharyngioma (43.4%), germinoma (11.3%), others (1.9%). Age at diagnosis was 7.1 ± 4.6 years. The median time from end of treatment was 1.9 (0-7.8) years. DI was the most frequent disorder after tumour treatment (50.3%) and was significantly associated with surgery (p < 0.001). Persistent CSWS was present in 3.6%, persistent SIADH in 1.3%. Two cases of hypernatraemia were due to adipsia. Thyrotropin deficiency after treatment was noted in 68.9% of patients tested, adrenocorticotropin deficiency in 66.2%. Conclusions: Patients with suprasellar tumours have a high incidence of long-term WED, mainly DI. Assessment of thyrotroph and corticotroph function, and thirst sensation, is necessary to diagnose and manage these disorders correctly. CSWS may be persistent in few patients and requires special attention to prescribe the appropriate care.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25377653</pmid><doi>10.1159/000368401</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5993-8077</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1663-2818 |
| ispartof | Hormone research in paediatrics, 2014-01, Vol.82 (6), p.364-371 |
| issn | 1663-2818 1663-2826 |
| language | eng |
| recordid | cdi_crossref_primary_10_1159_000368401 |
| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Brain Neoplasms - complications Brain Neoplasms - epidemiology Brain Neoplasms - therapy Child Child, Preschool Craniopharyngioma - complications Craniopharyngioma - epidemiology Craniopharyngioma - therapy Female Follow-Up Studies Glioma - complications Glioma - epidemiology Glioma - therapy Humans Inappropriate ADH Syndrome - epidemiology Inappropriate ADH Syndrome - etiology Incidence Infant Male Original Paper Pituitary Neoplasms - complications Pituitary Neoplasms - epidemiology Postoperative Complications - epidemiology Retrospective Studies Wasting Syndrome - epidemiology Wasting Syndrome - etiology Water-Electrolyte Imbalance - epidemiology Water-Electrolyte Imbalance - etiology |
| title | Water and Electrolyte Disorders at Long-Term Post-Treatment Follow-Up in Paediatric Patients with Suprasellar Tumours Include Unexpected Persistent Cerebral Salt-Wasting Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A13%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Water%20and%20Electrolyte%20Disorders%20at%20Long-Term%20Post-Treatment%20Follow-Up%20in%20Paediatric%20Patients%20with%20Suprasellar%20Tumours%20Include%20Unexpected%20Persistent%20Cerebral%20Salt-Wasting%20Syndrome&rft.jtitle=Hormone%20research%20in%20paediatrics&rft.au=Gonz%C3%A1lez%20Brice%C3%B1o,%20Laura&rft.date=2014-01-01&rft.volume=82&rft.issue=6&rft.spage=364&rft.epage=371&rft.pages=364-371&rft.issn=1663-2818&rft.eissn=1663-2826&rft_id=info:doi/10.1159/000368401&rft_dat=%3Cproquest_cross%3E3570185771%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1648396483&rft_id=info:pmid/25377653&rfr_iscdi=true |