T Lymphocytes and Acute Kidney Injury: Update
The immune system is among the key pathogenic factors in acute kidney injury (AKI). Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ lymphocytes are well established to participate in early injur...
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| Veröffentlicht in: | Nephron 2014-01, Vol.127 (1-4), p.51-55 |
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| container_title | Nephron |
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| creator | Martina, M.N. Noel, S. Bandapalle, S. Hamad, A.R.A. Rabb, H. |
| description | The immune system is among the key pathogenic factors in acute kidney injury (AKI). Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ lymphocytes are well established to participate in early injury, and CD4+CD25+FoxP3 regulatory T cells are protective and can accelerate repair. A newly identified kidney T cell receptor + CD4-CD8- (double-negative) T cell has complex functions, including potentially anti-inflammatory roles in AKI. In this mini review, we summarize the data on the role of lymphocytes in AKI and set the stage for further mechanistic studies as well as interventions to improve outcomes. |
| doi_str_mv | 10.1159/000363719 |
| format | Article |
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Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ lymphocytes are well established to participate in early injury, and CD4+CD25+FoxP3 regulatory T cells are protective and can accelerate repair. A newly identified kidney T cell receptor + CD4-CD8- (double-negative) T cell has complex functions, including potentially anti-inflammatory roles in AKI. In this mini review, we summarize the data on the role of lymphocytes in AKI and set the stage for further mechanistic studies as well as interventions to improve outcomes.</description><identifier>ISSN: 1660-2110</identifier><identifier>ISSN: 1660-8151</identifier><identifier>EISSN: 1660-2110</identifier><identifier>EISSN: 2235-3186</identifier><identifier>DOI: 10.1159/000363719</identifier><identifier>PMID: 25343821</identifier><identifier>CODEN: NPRNAY</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Acute Kidney Injury - complications Acute Kidney Injury - immunology Acute Kidney Injury - physiopathology Acute Kidney Injury - therapy Adoptive Transfer Animals Antigens, CD - analysis B7-1 Antigen - immunology CD4-Positive T-Lymphocytes - immunology Chemotaxis, Leukocyte Dendritic Cells - immunology Disease Models, Animal Humans Inflammation Kidney - blood supply Kidney - physiology Macrophages - immunology Mice Mice, Knockout Original Paper Regeneration Renal Replacement Therapy Reperfusion Injury - immunology T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology |
| title | T Lymphocytes and Acute Kidney Injury: Update |
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