Increased 14-3-3ζ Expression in the Multidrug-Resistant Leukemia Cell Line HL-60/VCR as Compared to the Parental Line Mediates Cell Growth and Apoptosis in Part through Modification of Gene Expression

Background: Acute myeloid leukemia (AML) recurrence is largely a result of multidrug resistance (MDR). We aimed to examine the role of 14-3-3ζ in AML chemosensitivity using HL-60 and vincristine-resistant HL-60/VCR cells. Methods: The effects of 14-3-3ζ siRNA on the growth and cell cycle progression...

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Veröffentlicht in:	Acta haematologica 2014-01, Vol.132 (2), p.177-186
Hauptverfasser:	Liang, Rong, Chen, Xie-Qun, Bai, Qin-Xian, Wang, Zhe, Zhang, Tao, Yang, Lan, Dong, Bao-Xia, Gao, Guang-Xun, Gu, Hong-Tao, Zhu, Hua-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - antagonists & inhibitors 14-3-3 Proteins - biosynthesis 14-3-3 Proteins - genetics 14-3-3 Proteins - physiology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis - genetics Apoptosis - physiology ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cell Cycle - drug effects Cell Cycle - genetics Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Gene Expression Profiling Gene Expression Regulation, Leukemic HL-60 Cells - drug effects HL-60 Cells - enzymology Humans Myeloid Cell Leukemia Sequence 1 Protein - biosynthesis Myeloid Cell Leukemia Sequence 1 Protein - genetics Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Oligonucleotide Array Sequence Analysis Original Paper Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics RNA Interference RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics RNA, Small Interfering - pharmacology Subcellular Fractions - metabolism Topoisomerase I Inhibitors - pharmacology Topotecan - pharmacology Vincristine - pharmacology
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