Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain
Introduction: There is a nondeveloped neurogenic potential in the adult mammalian brain, which could be the basis for neuroregenerative strategies. Many research efforts have been made to understand the control mechanisms which regulate the transition from a neural precursor to a neuron in the adult...
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| Veröffentlicht in: | Cells, tissues, organs tissues, organs, 2013-01, Vol.198 (5), p.398-404 |
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| creator | Carnicero, E. Alonso, M.I. Carretero, R. Lamus, F. Moro, J.A. de la Mano, A. Fernández, J.M.F. Gato, A. |
| description | Introduction: There is a nondeveloped neurogenic potential in the adult mammalian brain, which could be the basis for neuroregenerative strategies. Many research efforts have been made to understand the control mechanisms which regulate the transition from a neural precursor to a neuron in the adult brain. Embryonic cerebrospinal fluid (CSF) is a complex fluid which has been shown to play a key role in neural precursor behavior during development, working as a powerful neurogenic inductor. We tested if the neurogenic properties of embryonic CSF are able to increase the neurogenic activity of neuronal precursors from the subventricular zone (SVZ) in the brains of adult mice. Results: Our results show that mouse embryonic CSF significantly increases the neurogenic activity in precursor cells from adult brain SVZ. This intense neurogenic effect was specific for embryonic CSF and was not induced by adult CSF. Conclusions: Embryonic CSF is a powerful neurogenesis inductor in homologous neuronal precursors in the adult brain. This property of embryonic CSF could be a useful tool in neuroregeneration strategies. |
| doi_str_mv | 10.1159/000356983 |
| format | Article |
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Many research efforts have been made to understand the control mechanisms which regulate the transition from a neural precursor to a neuron in the adult brain. Embryonic cerebrospinal fluid (CSF) is a complex fluid which has been shown to play a key role in neural precursor behavior during development, working as a powerful neurogenic inductor. We tested if the neurogenic properties of embryonic CSF are able to increase the neurogenic activity of neuronal precursors from the subventricular zone (SVZ) in the brains of adult mice. Results: Our results show that mouse embryonic CSF significantly increases the neurogenic activity in precursor cells from adult brain SVZ. This intense neurogenic effect was specific for embryonic CSF and was not induced by adult CSF. Conclusions: Embryonic CSF is a powerful neurogenesis inductor in homologous neuronal precursors in the adult brain. This property of embryonic CSF could be a useful tool in neuroregeneration strategies.</description><identifier>ISSN: 1422-6405</identifier><identifier>EISSN: 1422-6421</identifier><identifier>DOI: 10.1159/000356983</identifier><identifier>PMID: 24401814</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Brain - cytology ; Cell Differentiation - physiology ; Cell Growth Processes - physiology ; Cerebral Cortex - embryology ; Cerebrospinal Fluid - physiology ; Mice ; Neurogenesis ; Neurons - cytology ; Original Paper</subject><ispartof>Cells, tissues, organs, 2013-01, Vol.198 (5), p.398-404</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>Copyright (c) 2014 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-28783f13f681c2958317ac2d48241d0e4af6a569b050aea477c6821876f30d283</citedby><cites>FETCH-LOGICAL-c402t-28783f13f681c2958317ac2d48241d0e4af6a569b050aea477c6821876f30d283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24401814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carnicero, E.</creatorcontrib><creatorcontrib>Alonso, M.I.</creatorcontrib><creatorcontrib>Carretero, R.</creatorcontrib><creatorcontrib>Lamus, F.</creatorcontrib><creatorcontrib>Moro, J.A.</creatorcontrib><creatorcontrib>de la Mano, A.</creatorcontrib><creatorcontrib>Fernández, J.M.F.</creatorcontrib><creatorcontrib>Gato, A.</creatorcontrib><title>Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain</title><title>Cells, tissues, organs</title><addtitle>Cells Tissues Organs</addtitle><description>Introduction: There is a nondeveloped neurogenic potential in the adult mammalian brain, which could be the basis for neuroregenerative strategies. 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This property of embryonic CSF could be a useful tool in neuroregeneration strategies.</description><subject>Animals</subject><subject>Brain - cytology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Growth Processes - physiology</subject><subject>Cerebral Cortex - embryology</subject><subject>Cerebrospinal Fluid - physiology</subject><subject>Mice</subject><subject>Neurogenesis</subject><subject>Neurons - cytology</subject><subject>Original Paper</subject><issn>1422-6405</issn><issn>1422-6421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0TtPwzAQB3ALgXgUBnaELLHAULAdJ3HHUvGSeEnAwhI5zgUMaVzOMYiRb45LSwcmJtu6352s-xOyzdkh5-ngiDGWpNlAJUtknUsh-pkUfHlxZ-ka2fD-JTIRC6tkTUjJuOJynXydjEv8dK01dAQIJTo_sa1u6GkTbEWHprPvugNPryGge4IWvPXU1T_vyG4RTEDv0NMP2z3blnbPQO9C-Q5th9aERiN9dC1Me6alYRWajl654IEeo7btJlmpdeNha372yMPpyf3ovH95c3YxGl72jWSi6wuVq6TmSZ0pbsQgVQnPtRGVVELyioHUdabjEkqWMg1a5rnJlOAqz-qEVUIlPbI_mztB9xbAd8XYegNNo1uIvyl4GpfCBM_yf9CohGRSRrr3h764gHGBPypnapDFcHrkYKZM3K9HqIsJ2rHGz4KzYhphsYgw2t35xFCOoVrI38wi2JmBV41PgAsw7_8Gk56eBQ</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Carnicero, E.</creator><creator>Alonso, M.I.</creator><creator>Carretero, R.</creator><creator>Lamus, F.</creator><creator>Moro, J.A.</creator><creator>de la Mano, A.</creator><creator>Fernández, J.M.F.</creator><creator>Gato, A.</creator><general>S. 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| ispartof | Cells, tissues, organs, 2013-01, Vol.198 (5), p.398-404 |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Brain - cytology Cell Differentiation - physiology Cell Growth Processes - physiology Cerebral Cortex - embryology Cerebrospinal Fluid - physiology Mice Neurogenesis Neurons - cytology Original Paper |
| title | Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain |
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