Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels

Background/Aims: Endothelial nitric oxide synthase (eNOS) is associated with caveolin-1 (Cav-1) in plasma membrane. We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-b...

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Veröffentlicht in:	Journal of vascular research 2013-01, Vol.50 (6), p.498-511
Hauptverfasser:	Figueroa, Xavier F., González, Daniel R., Puebla, Mariela, Acevedo, Juan P., Rojas-Libano, Daniel, Durán, Walter N., Boric, Mauricio P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Flow Velocity Calcium - metabolism Caveolin 1 - metabolism Enzyme Activation Male Mechanotransduction, Cellular Mesenteric Arteries - enzymology Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Protein Transport Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Regional Blood Flow Research Paper Serine Splanchnic Circulation Stress, Mechanical Time Factors Vascular Resistance
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