Aging-Dependent Reduction in Glyoxalase 1 Delays Wound Healing

Methylglyoxal (MG), the major dicarbonyl substrate of the enzyme glyoxalase 1 (GLO1), is a reactive metabolite formed via glycolytic flux. Decreased GLO1 activity in situ has been shown to result in an accumulation of MG and increased formation of advanced glycation endproducts, both of which can ac...

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Veröffentlicht in:	Gerontology (Basel) 2013-01, Vol.59 (5), p.427-437
Hauptverfasser:	Fleming, Thomas H., Theilen, Till-Martin, Masania, Jinit, Wunderle, Marius, Karimi, Jamshid, Vittas, Spiros, Bernauer, Rainer, Bierhaus, Angelika, Rabbani, Naila, Thornalley, Paul J., Kroll, Jens, Tyedmers, Jens, Nawrotzki, Ralph, Herzig, Stephan, Brownlee, Michael, Nawroth, Peter P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Aging - physiology Animals Biological and medical sciences Cells, Cultured Development. Metamorphosis. Moult. Ageing Down-Regulation Enzymes Experimental Section / Original Paper Fibroblasts - drug effects Fibroblasts - physiology Fundamental and applied biological sciences. Psychology Geriatrics Guanidines - pharmacology Lactoylglutathione Lyase - antagonists & inhibitors Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - physiology Male Mice Mice, Inbred C57BL Pyruvaldehyde - metabolism Pyruvaldehyde - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems Wound healing Wound Healing - drug effects Wound Healing - genetics Wound Healing - physiology
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