Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents
Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents w...
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| Veröffentlicht in: | Obesity facts 2012, Vol.5 (6), p.806-820 |
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| creator | Leão da Silva, Patrícia Túlio de Mello, Marco Cheik, Nadia Carla Lima Sanches, Priscila Munhoz da Silveira Campos, Raquel Carnier, June Inoue, Daniela do Nascimento, Claudia M.O. Oyama, Lila M. Tock, Lian Tufik, Sérgio Dâmaso, Ana R. |
| description | Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (2.5 and |
| doi_str_mv | 10.1159/000345840 |
| format | Article |
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Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function.</description><identifier>ISSN: 1662-4025</identifier><identifier>EISSN: 1662-4033</identifier><identifier>DOI: 10.1159/000345840</identifier><identifier>PMID: 23207491</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adiponectin - blood ; Adolescent ; Asthma - blood ; Asthma - complications ; Asthma - physiopathology ; Asthma - therapy ; Asthma, Exercise-Induced - blood ; Asthma, Exercise-Induced - complications ; Asthma, Exercise-Induced - physiopathology ; Asthma, Exercise-Induced - therapy ; Diet ; Exercise ; Female ; Humans ; Leptin - blood ; Lung - physiopathology ; Male ; Obesity - blood ; Obesity - complications ; Obesity - physiopathology ; Obesity - therapy ; Original Article ; Physical Therapy Modalities ; Psychotherapy ; Weight Loss ; Weight Reduction Programs</subject><ispartof>Obesity facts, 2012, Vol.5 (6), p.806-820</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-f58a5cf847693d46b1a95b318c76e16248b11ef8f86a53ea7b4222297bfbc0453</citedby><cites>FETCH-LOGICAL-c369t-f58a5cf847693d46b1a95b318c76e16248b11ef8f86a53ea7b4222297bfbc0453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23207491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leão da Silva, Patrícia</creatorcontrib><creatorcontrib>Túlio de Mello, Marco</creatorcontrib><creatorcontrib>Cheik, Nadia Carla</creatorcontrib><creatorcontrib>Lima Sanches, Priscila</creatorcontrib><creatorcontrib>Munhoz da Silveira Campos, Raquel</creatorcontrib><creatorcontrib>Carnier, June</creatorcontrib><creatorcontrib>Inoue, Daniela</creatorcontrib><creatorcontrib>do Nascimento, Claudia M.O.</creatorcontrib><creatorcontrib>Oyama, Lila M.</creatorcontrib><creatorcontrib>Tock, Lian</creatorcontrib><creatorcontrib>Tufik, Sérgio</creatorcontrib><creatorcontrib>Dâmaso, Ana R.</creatorcontrib><title>Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents</title><title>Obesity facts</title><addtitle>Obes Facts</addtitle><description>Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function.</description><subject>Adiponectin - blood</subject><subject>Adolescent</subject><subject>Asthma - blood</subject><subject>Asthma - complications</subject><subject>Asthma - physiopathology</subject><subject>Asthma - therapy</subject><subject>Asthma, Exercise-Induced - blood</subject><subject>Asthma, Exercise-Induced - complications</subject><subject>Asthma, Exercise-Induced - physiopathology</subject><subject>Asthma, Exercise-Induced - therapy</subject><subject>Diet</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Original Article</subject><subject>Physical Therapy Modalities</subject><subject>Psychotherapy</subject><subject>Weight Loss</subject><subject>Weight Reduction Programs</subject><issn>1662-4025</issn><issn>1662-4033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAUx4Mobk4P3kUCXvRQTZofbY9jOB0UJqLnkrYvs9o2M2kF_3szO3syl_fgffJ5jy9C55TcUiqSO0II4yLm5ABNqZRhwAljh2Mfigk6ce6dEEl5RI_RJGQhiXhCp6h6hrIvusq0uGpx9wY4hW3n24VpC2g7q35nymGFnyyUVdEZi43Gq2ZrzRc0ntn9TPt2g5d9O6rWOTjA89LU4HYid4qOtKodnO3rDL0u718Wj0G6flgt5mlQMJl0gRaxEoWOeSQTVnKZU5WInNG4iCRQGfI4pxR0rGOpBAMV5Tz0L4lynReECzZD14PX3_fZg-uypvIX1LVqwfQuo4yGNOKCJB69GdDCGucs6Gxrq0bZ74ySbJdsNibr2cu9ts8bKEfyL0oPXA3Ah7IbsCOwXs4HRbYttacu_qX2W34An8WHmA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Leão da Silva, Patrícia</creator><creator>Túlio de Mello, Marco</creator><creator>Cheik, Nadia Carla</creator><creator>Lima Sanches, Priscila</creator><creator>Munhoz da Silveira Campos, Raquel</creator><creator>Carnier, June</creator><creator>Inoue, Daniela</creator><creator>do Nascimento, Claudia M.O.</creator><creator>Oyama, Lila M.</creator><creator>Tock, Lian</creator><creator>Tufik, Sérgio</creator><creator>Dâmaso, Ana R.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents</title><author>Leão da Silva, Patrícia ; Túlio de Mello, Marco ; Cheik, Nadia Carla ; Lima Sanches, Priscila ; Munhoz da Silveira Campos, Raquel ; Carnier, June ; Inoue, Daniela ; do Nascimento, Claudia M.O. ; Oyama, Lila M. ; Tock, Lian ; Tufik, Sérgio ; Dâmaso, Ana R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-f58a5cf847693d46b1a95b318c76e16248b11ef8f86a53ea7b4222297bfbc0453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiponectin - blood</topic><topic>Adolescent</topic><topic>Asthma - blood</topic><topic>Asthma - complications</topic><topic>Asthma - physiopathology</topic><topic>Asthma - therapy</topic><topic>Asthma, Exercise-Induced - blood</topic><topic>Asthma, Exercise-Induced - complications</topic><topic>Asthma, Exercise-Induced - physiopathology</topic><topic>Asthma, Exercise-Induced - therapy</topic><topic>Diet</topic><topic>Exercise</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Original Article</topic><topic>Physical Therapy Modalities</topic><topic>Psychotherapy</topic><topic>Weight Loss</topic><topic>Weight Reduction Programs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leão da Silva, Patrícia</creatorcontrib><creatorcontrib>Túlio de Mello, Marco</creatorcontrib><creatorcontrib>Cheik, Nadia Carla</creatorcontrib><creatorcontrib>Lima Sanches, Priscila</creatorcontrib><creatorcontrib>Munhoz da Silveira Campos, Raquel</creatorcontrib><creatorcontrib>Carnier, June</creatorcontrib><creatorcontrib>Inoue, Daniela</creatorcontrib><creatorcontrib>do Nascimento, Claudia M.O.</creatorcontrib><creatorcontrib>Oyama, Lila M.</creatorcontrib><creatorcontrib>Tock, Lian</creatorcontrib><creatorcontrib>Tufik, Sérgio</creatorcontrib><creatorcontrib>Dâmaso, Ana R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity facts</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leão da Silva, Patrícia</au><au>Túlio de Mello, Marco</au><au>Cheik, Nadia Carla</au><au>Lima Sanches, Priscila</au><au>Munhoz da Silveira Campos, Raquel</au><au>Carnier, June</au><au>Inoue, Daniela</au><au>do Nascimento, Claudia M.O.</au><au>Oyama, Lila M.</au><au>Tock, Lian</au><au>Tufik, Sérgio</au><au>Dâmaso, Ana R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents</atitle><jtitle>Obesity facts</jtitle><addtitle>Obes Facts</addtitle><date>2012</date><risdate>2012</risdate><volume>5</volume><issue>6</issue><spage>806</spage><epage>820</epage><pages>806-820</pages><issn>1662-4025</issn><eissn>1662-4033</eissn><abstract>Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function.</abstract><cop>Basel, Switzerland</cop><pmid>23207491</pmid><doi>10.1159/000345840</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adolescent Asthma - blood Asthma - complications Asthma - physiopathology Asthma - therapy Asthma, Exercise-Induced - blood Asthma, Exercise-Induced - complications Asthma, Exercise-Induced - physiopathology Asthma, Exercise-Induced - therapy Diet Exercise Female Humans Leptin - blood Lung - physiopathology Male Obesity - blood Obesity - complications Obesity - physiopathology Obesity - therapy Original Article Physical Therapy Modalities Psychotherapy Weight Loss Weight Reduction Programs |
| title | Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents |
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