Modulation of Free Corticotrophin-Releasing Hormone, Adrenal and Placental Steroid Hormone Levels Induced by Mifepristone during Pregnancy
Mifepristone is a progesterone receptor antagonist widely used in obstetrics. The aim of the study was to focus on free corticotrophin-releasing hormone (CRH) and also describe modulation of adrenal and placental steroid hormone concentrations induced by mifepristone. Methods: Twenty-six women were...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2012-01, Vol.32 (4), p.267-270 |
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| creator | Ceccaldi, Pierre-François Saada, Julien Nicolas, Mireille Ducarme, Guillaume Blot, Philippe Guibourdenche, Jean Luton, Dominique |
| description | Mifepristone is a progesterone receptor antagonist widely used in obstetrics. The aim of the study was to focus on free corticotrophin-releasing hormone (CRH) and also describe modulation of adrenal and placental steroid hormone concentrations induced by mifepristone. Methods: Twenty-six women were enrolled in the study. They received mifepristone for termination of pregnancy. Maternal blood samples were retrieved before administration of mifepristone (600 mg) and 48 h after, just before induction of labor. Bound and free CRH levels were determined in maternal blood concomitantly with cortisol, estriol, progesterone and SDHEA levels. Also paired fetal cord blood samples were collected. Results: Maternal plasmatic CRH level did not change after mifepristone absorption but free CRH increased significantly (0.500 ± 0.326 vs. 0.388 ± 0.303 ng/ml, p = 0.040). A significant decrease of progesterone was observed (83.6 ± 49.3 vs. 95.6 ± 54.9 ng/ml, p = 0.001) with a lower progesterone/estriol ratio (26.9 ± 15.7 vs. 40.7 ± 31.1, p = 0.004). There was a strong association between maternal and fetal free CRH (r 2 = 0.675, p = 0.001), cortisol (r 2 = 0.570, p = 0.019), and positive but modest correlation for progesterone (r 2 = 0.341, p = 0.046) and estriol (r 2 = 0.379, p = 0.025) levels. Conclusion: Mifepristone has an effect on free CRH level and changes the estriol-progesterone balance. |
| doi_str_mv | 10.1159/000338927 |
| format | Article |
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The aim of the study was to focus on free corticotrophin-releasing hormone (CRH) and also describe modulation of adrenal and placental steroid hormone concentrations induced by mifepristone. Methods: Twenty-six women were enrolled in the study. They received mifepristone for termination of pregnancy. Maternal blood samples were retrieved before administration of mifepristone (600 mg) and 48 h after, just before induction of labor. Bound and free CRH levels were determined in maternal blood concomitantly with cortisol, estriol, progesterone and SDHEA levels. Also paired fetal cord blood samples were collected. Results: Maternal plasmatic CRH level did not change after mifepristone absorption but free CRH increased significantly (0.500 ± 0.326 vs. 0.388 ± 0.303 ng/ml, p = 0.040). A significant decrease of progesterone was observed (83.6 ± 49.3 vs. 95.6 ± 54.9 ng/ml, p = 0.001) with a lower progesterone/estriol ratio (26.9 ± 15.7 vs. 40.7 ± 31.1, p = 0.004). There was a strong association between maternal and fetal free CRH (r 2 = 0.675, p = 0.001), cortisol (r 2 = 0.570, p = 0.019), and positive but modest correlation for progesterone (r 2 = 0.341, p = 0.046) and estriol (r 2 = 0.379, p = 0.025) levels. Conclusion: Mifepristone has an effect on free CRH level and changes the estriol-progesterone balance.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000338927</identifier><identifier>PMID: 22759411</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Abortifacient Agents, Steroidal - pharmacology ; Abortion, Therapeutic ; Adrenal Cortex - drug effects ; Adrenal Cortex - secretion ; Adult ; Algorithms ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Corticotropin-Releasing Hormone - blood ; Corticotropin-Releasing Hormone - metabolism ; Corticotropin-Releasing Hormone - secretion ; Dehydroepiandrosterone Sulfate - blood ; Delivery. Postpartum. Lactation ; Estriol - blood ; Estriol - secretion ; Female ; Fetal Blood - metabolism ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Hydrocortisone - blood ; Hydrocortisone - secretion ; Medical sciences ; Mifepristone - pharmacology ; Original Paper ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - secretion ; Pharmacology. Drug treatments ; Placenta - drug effects ; Placenta - secretion ; Pregnancy ; Pregnancy Trimester, Third ; Progesterone - blood ; Progesterone - secretion ; Receptors, Progesterone - antagonists & inhibitors</subject><ispartof>Fetal diagnosis and therapy, 2012-01, Vol.32 (4), p.267-270</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><rights>Copyright (c) 2012 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-e14c0e76ba39c4993a60b786b7e74d3b02fcee8cf29f9ce75729c53e3ecbf8003</citedby><cites>FETCH-LOGICAL-c434t-e14c0e76ba39c4993a60b786b7e74d3b02fcee8cf29f9ce75729c53e3ecbf8003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26727699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22759411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ceccaldi, Pierre-François</creatorcontrib><creatorcontrib>Saada, Julien</creatorcontrib><creatorcontrib>Nicolas, Mireille</creatorcontrib><creatorcontrib>Ducarme, Guillaume</creatorcontrib><creatorcontrib>Blot, Philippe</creatorcontrib><creatorcontrib>Guibourdenche, Jean</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><title>Modulation of Free Corticotrophin-Releasing Hormone, Adrenal and Placental Steroid Hormone Levels Induced by Mifepristone during Pregnancy</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Mifepristone is a progesterone receptor antagonist widely used in obstetrics. The aim of the study was to focus on free corticotrophin-releasing hormone (CRH) and also describe modulation of adrenal and placental steroid hormone concentrations induced by mifepristone. Methods: Twenty-six women were enrolled in the study. They received mifepristone for termination of pregnancy. Maternal blood samples were retrieved before administration of mifepristone (600 mg) and 48 h after, just before induction of labor. Bound and free CRH levels were determined in maternal blood concomitantly with cortisol, estriol, progesterone and SDHEA levels. Also paired fetal cord blood samples were collected. Results: Maternal plasmatic CRH level did not change after mifepristone absorption but free CRH increased significantly (0.500 ± 0.326 vs. 0.388 ± 0.303 ng/ml, p = 0.040). A significant decrease of progesterone was observed (83.6 ± 49.3 vs. 95.6 ± 54.9 ng/ml, p = 0.001) with a lower progesterone/estriol ratio (26.9 ± 15.7 vs. 40.7 ± 31.1, p = 0.004). There was a strong association between maternal and fetal free CRH (r 2 = 0.675, p = 0.001), cortisol (r 2 = 0.570, p = 0.019), and positive but modest correlation for progesterone (r 2 = 0.341, p = 0.046) and estriol (r 2 = 0.379, p = 0.025) levels. Conclusion: Mifepristone has an effect on free CRH level and changes the estriol-progesterone balance.</description><subject>Abortifacient Agents, Steroidal - pharmacology</subject><subject>Abortion, Therapeutic</subject><subject>Adrenal Cortex - drug effects</subject><subject>Adrenal Cortex - secretion</subject><subject>Adult</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Corticotropin-Releasing Hormone - blood</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Corticotropin-Releasing Hormone - secretion</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Estriol - blood</subject><subject>Estriol - secretion</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hydrocortisone - secretion</subject><subject>Medical sciences</subject><subject>Mifepristone - pharmacology</subject><subject>Original Paper</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - secretion</subject><subject>Pharmacology. Drug treatments</subject><subject>Placenta - drug effects</subject><subject>Placenta - secretion</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Progesterone - blood</subject><subject>Progesterone - secretion</subject><subject>Receptors, Progesterone - antagonists & inhibitors</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0V1rFDEUBuBQFFu3XngvEhBBwWnzMTOZXJbF2sIWSz-uh0xysqZmkzWZEfYv-KvNstsVvErCeTjhvAeht5ScUdrIc0II551k4gid0JrRSsq2flHuhDYV77g4Rq9zfiqsE7x9hY4ZE42sKT1Bf26imbwaXQw4WnyZAPA8ptHpOKa4_uFCdQceVHZhia9iWsUAX_CFSRCUxyoYfOuVhjCW1_0IKTrzzPACfoPP-DqYSYPBwwbfOAvr5PK4LZspbZveJlgGFfTmFL20ymd4sz9n6PHy68P8qlp8_3Y9v1hUuub1WAGtNQHRDopLXUvJVUsG0bWDAFEbPhBmNUCnLZNWahCNYFI3HDjowXYlqRn6tOu7TvHXBHnsVy5r8F4FiFPuKeOiIZ3kvNAP_9GnOKUyeVG8OFpyZkV93imdYs4JbF9mXKm06SnptwvqDwsq9v2-4zSswBzk80YK-LgHKmvlbSrRuPzPtYKJtkw9Q-927qdKS0gHsP_nL1yIohw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Ceccaldi, Pierre-François</creator><creator>Saada, Julien</creator><creator>Nicolas, Mireille</creator><creator>Ducarme, Guillaume</creator><creator>Blot, Philippe</creator><creator>Guibourdenche, Jean</creator><creator>Luton, Dominique</creator><general>Karger</general><general>S. 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Antiinflammatory agents</topic><topic>Corticotropin-Releasing Hormone - blood</topic><topic>Corticotropin-Releasing Hormone - metabolism</topic><topic>Corticotropin-Releasing Hormone - secretion</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Estriol - blood</topic><topic>Estriol - secretion</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - secretion</topic><topic>Medical sciences</topic><topic>Mifepristone - pharmacology</topic><topic>Original Paper</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - secretion</topic><topic>Pharmacology. Drug treatments</topic><topic>Placenta - drug effects</topic><topic>Placenta - secretion</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>Progesterone - blood</topic><topic>Progesterone - secretion</topic><topic>Receptors, Progesterone - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceccaldi, Pierre-François</creatorcontrib><creatorcontrib>Saada, Julien</creatorcontrib><creatorcontrib>Nicolas, Mireille</creatorcontrib><creatorcontrib>Ducarme, Guillaume</creatorcontrib><creatorcontrib>Blot, Philippe</creatorcontrib><creatorcontrib>Guibourdenche, Jean</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceccaldi, Pierre-François</au><au>Saada, Julien</au><au>Nicolas, Mireille</au><au>Ducarme, Guillaume</au><au>Blot, Philippe</au><au>Guibourdenche, Jean</au><au>Luton, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Free Corticotrophin-Releasing Hormone, Adrenal and Placental Steroid Hormone Levels Induced by Mifepristone during Pregnancy</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>32</volume><issue>4</issue><spage>267</spage><epage>270</epage><pages>267-270</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Mifepristone is a progesterone receptor antagonist widely used in obstetrics. The aim of the study was to focus on free corticotrophin-releasing hormone (CRH) and also describe modulation of adrenal and placental steroid hormone concentrations induced by mifepristone. Methods: Twenty-six women were enrolled in the study. They received mifepristone for termination of pregnancy. Maternal blood samples were retrieved before administration of mifepristone (600 mg) and 48 h after, just before induction of labor. Bound and free CRH levels were determined in maternal blood concomitantly with cortisol, estriol, progesterone and SDHEA levels. Also paired fetal cord blood samples were collected. Results: Maternal plasmatic CRH level did not change after mifepristone absorption but free CRH increased significantly (0.500 ± 0.326 vs. 0.388 ± 0.303 ng/ml, p = 0.040). A significant decrease of progesterone was observed (83.6 ± 49.3 vs. 95.6 ± 54.9 ng/ml, p = 0.001) with a lower progesterone/estriol ratio (26.9 ± 15.7 vs. 40.7 ± 31.1, p = 0.004). There was a strong association between maternal and fetal free CRH (r 2 = 0.675, p = 0.001), cortisol (r 2 = 0.570, p = 0.019), and positive but modest correlation for progesterone (r 2 = 0.341, p = 0.046) and estriol (r 2 = 0.379, p = 0.025) levels. Conclusion: Mifepristone has an effect on free CRH level and changes the estriol-progesterone balance.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>22759411</pmid><doi>10.1159/000338927</doi><tpages>4</tpages></addata></record> |
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| ispartof | Fetal diagnosis and therapy, 2012-01, Vol.32 (4), p.267-270 |
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| subjects | Abortifacient Agents, Steroidal - pharmacology Abortion, Therapeutic Adrenal Cortex - drug effects Adrenal Cortex - secretion Adult Algorithms Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Corticotropin-Releasing Hormone - blood Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - secretion Dehydroepiandrosterone Sulfate - blood Delivery. Postpartum. Lactation Estriol - blood Estriol - secretion Female Fetal Blood - metabolism General aspects Gynecology. Andrology. Obstetrics Humans Hydrocortisone - blood Hydrocortisone - secretion Medical sciences Mifepristone - pharmacology Original Paper Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - secretion Pharmacology. Drug treatments Placenta - drug effects Placenta - secretion Pregnancy Pregnancy Trimester, Third Progesterone - blood Progesterone - secretion Receptors, Progesterone - antagonists & inhibitors |
| title | Modulation of Free Corticotrophin-Releasing Hormone, Adrenal and Placental Steroid Hormone Levels Induced by Mifepristone during Pregnancy |
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