Phase II Study of Combined Treatment with Irinotecan and S-1 (IRIS) in Patients with Inoperable or Recurrent Advanced Colorectal Cancer (HGCSG0302)

Objectives: This phase II study was designed to evaluate the efficacy and safety of oral fluoropyrimidine S-1 plus irinotecan (IRIS regimen) in patients with previously untreated metastatic colorectal cancer. Methods: The response rate was the primary endpoint. Safety, progression-free survival time...

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Veröffentlicht in:	Oncology 2011-01, Vol.80 (1-2), p.70-75
Hauptverfasser:	Komatsu, Yoshito, Yuki, Satoshi, Sogabe, Susumu, Fukushima, Hiraku, Iwanaga, Ichiro, Kudo, Mineo, Tateyama, Miki, Meguro, Takashi, Uebayashi, Minoru, Saga, Akiyoshi, Sakata, Yuh, Asaka, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Adult Aged Anemia - chemically induced Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Camptothecin - administration & dosage Camptothecin - analogs & derivatives Chemotherapy Clinical Study Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Drug Combinations Female Gastroenterology. Liver. Pancreas. Abdomen Humans Leukopenia - chemically induced Male Medical sciences Metastasis Middle Aged Neoplasm Recurrence, Local - drug therapy Neutropenia - chemically induced Oxonic Acid - administration & dosage Side effects Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tegafur - administration & dosage Treatment Outcome Tumors
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