Comparison of 7.0-T T2-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates
Background: In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia. Materials and Methods: Out of 20 post-mortem brains of patients with Alzheimer dementia...
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| Veröffentlicht in: | Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2011, Vol.31 (5), p.511-517 |
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| creator | De Reuck, J. Auger, F. Cordonnier, C. Deramecourt, V. Durieux, N. Pasquier, F. Bordet, R. Maurage, C.A. Leys, D. |
| description | Background: In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia. Materials and Methods: Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T 2 *-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs). Results: The sensitivity, specificity, predictive positive value and predictive negative value of the T 2 * imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T 2 * hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi. Conclusions: When evaluating the ‘bleeding load’ with 7.0-T T 2 *-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable. |
| doi_str_mv | 10.1159/000324391 |
| format | Article |
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Materials and Methods: Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T 2 *-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs). Results: The sensitivity, specificity, predictive positive value and predictive negative value of the T 2 * imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T 2 * hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi. Conclusions: When evaluating the ‘bleeding load’ with 7.0-T T 2 *-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable.</description><identifier>ISSN: 1015-9770</identifier><identifier>EISSN: 1421-9786</identifier><identifier>DOI: 10.1159/000324391</identifier><identifier>PMID: 21422755</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Alzheimer's disease ; Autopsy ; Brain - pathology ; Cerebral Amyloid Angiopathy - pathology ; Cerebral Arteries - pathology ; Cerebral Hemorrhage - diagnosis ; Cerebral Hemorrhage - pathology ; Cerebrovascular Disorders - pathology ; Female ; Humans ; Iron - metabolism ; Magnetic Resonance Imaging - methods ; Male ; Original Paper ; Paraffin Embedding ; Postmortem Changes ; Predictive Value of Tests ; Risk Factors ; Thromboembolism - pathology</subject><ispartof>Cerebrovascular diseases (Basel, Switzerland), 2011, Vol.31 (5), p.511-517</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c279t-580a400db930a04e9d6d702eb9d00420f8d17935d4aff75261d3f52ac6abec13</citedby><cites>FETCH-LOGICAL-c279t-580a400db930a04e9d6d702eb9d00420f8d17935d4aff75261d3f52ac6abec13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21422755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Reuck, J.</creatorcontrib><creatorcontrib>Auger, F.</creatorcontrib><creatorcontrib>Cordonnier, C.</creatorcontrib><creatorcontrib>Deramecourt, V.</creatorcontrib><creatorcontrib>Durieux, N.</creatorcontrib><creatorcontrib>Pasquier, F.</creatorcontrib><creatorcontrib>Bordet, R.</creatorcontrib><creatorcontrib>Maurage, C.A.</creatorcontrib><creatorcontrib>Leys, D.</creatorcontrib><title>Comparison of 7.0-T T2-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates</title><title>Cerebrovascular diseases (Basel, Switzerland)</title><addtitle>Cerebrovasc Dis</addtitle><description>Background: In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia. Materials and Methods: Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T 2 *-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs). Results: The sensitivity, specificity, predictive positive value and predictive negative value of the T 2 * imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T 2 * hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi. Conclusions: When evaluating the ‘bleeding load’ with 7.0-T T 2 *-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Autopsy</subject><subject>Brain - pathology</subject><subject>Cerebral Amyloid Angiopathy - pathology</subject><subject>Cerebral Arteries - pathology</subject><subject>Cerebral Hemorrhage - diagnosis</subject><subject>Cerebral Hemorrhage - pathology</subject><subject>Cerebrovascular Disorders - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Iron - metabolism</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Original Paper</subject><subject>Paraffin Embedding</subject><subject>Postmortem Changes</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Thromboembolism - pathology</subject><issn>1015-9770</issn><issn>1421-9786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0U1v1DAQBmALgegHHLgjZHGpOKTYjh0nxzbio1ILFeQeOfYk65LYi-0Iwa_hp-LVLnvgwsmj8TMjjV6EXlBySalo3hJCSsbLhj5Cp5QzWjSyrh7nmlCRa0lO0FmMD5lVtKZP0QnLikkhTtHv1i9bFWz0DvsRy0tSdLhjxZ2aHCSr8RfIX8ppwDeLmqybdqyFAENQM76eAUzE1uF7H1Nx50OCBV8HlTtfQSfrXdwNXM2_NmAXCPheJQsuRfzDpg3ucjfgT7AGv1Vp42c_WZ33tj4EmFWC-Aw9GdUc4fnhPUfd-3dd-7G4_fzhpr26LTSTTSpETRQnxAxNSRTh0JjKSMJgaAwhnJGxNlQ2pTBcjaMUrKKmHAVTulIDaFqeo4v92m3w31eIqV9s1DDPyoFfY19LTuuG1-z_sqKM1KziWb7-Rz74Nbh8RUZc8BxamdGbPdLBxxhg7LfBLir87Cnpd-n2x3SzfXVYuA4LmKP8G2cGL_fgmwoThCM4zP8B0jun9g</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>De Reuck, J.</creator><creator>Auger, F.</creator><creator>Cordonnier, C.</creator><creator>Deramecourt, V.</creator><creator>Durieux, N.</creator><creator>Pasquier, F.</creator><creator>Bordet, R.</creator><creator>Maurage, C.A.</creator><creator>Leys, D.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Comparison of 7.0-T T2-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates</title><author>De Reuck, J. ; Auger, F. ; Cordonnier, C. ; Deramecourt, V. ; Durieux, N. ; Pasquier, F. ; Bordet, R. ; Maurage, C.A. ; Leys, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-580a400db930a04e9d6d702eb9d00420f8d17935d4aff75261d3f52ac6abec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Autopsy</topic><topic>Brain - pathology</topic><topic>Cerebral Amyloid Angiopathy - pathology</topic><topic>Cerebral Arteries - pathology</topic><topic>Cerebral Hemorrhage - diagnosis</topic><topic>Cerebral Hemorrhage - pathology</topic><topic>Cerebrovascular Disorders - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Iron - metabolism</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Original Paper</topic><topic>Paraffin Embedding</topic><topic>Postmortem Changes</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Thromboembolism - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Reuck, J.</creatorcontrib><creatorcontrib>Auger, F.</creatorcontrib><creatorcontrib>Cordonnier, C.</creatorcontrib><creatorcontrib>Deramecourt, V.</creatorcontrib><creatorcontrib>Durieux, N.</creatorcontrib><creatorcontrib>Pasquier, F.</creatorcontrib><creatorcontrib>Bordet, R.</creatorcontrib><creatorcontrib>Maurage, C.A.</creatorcontrib><creatorcontrib>Leys, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Reuck, J.</au><au>Auger, F.</au><au>Cordonnier, C.</au><au>Deramecourt, V.</au><au>Durieux, N.</au><au>Pasquier, F.</au><au>Bordet, R.</au><au>Maurage, C.A.</au><au>Leys, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of 7.0-T T2-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates</atitle><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle><addtitle>Cerebrovasc Dis</addtitle><date>2011</date><risdate>2011</risdate><volume>31</volume><issue>5</issue><spage>511</spage><epage>517</epage><pages>511-517</pages><issn>1015-9770</issn><eissn>1421-9786</eissn><abstract>Background: In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia. Materials and Methods: Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T 2 *-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs). Results: The sensitivity, specificity, predictive positive value and predictive negative value of the T 2 * imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T 2 * hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi. Conclusions: When evaluating the ‘bleeding load’ with 7.0-T T 2 *-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21422755</pmid><doi>10.1159/000324391</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cerebrovascular diseases (Basel, Switzerland), 2011, Vol.31 (5), p.511-517 |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer's disease Autopsy Brain - pathology Cerebral Amyloid Angiopathy - pathology Cerebral Arteries - pathology Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - pathology Cerebrovascular Disorders - pathology Female Humans Iron - metabolism Magnetic Resonance Imaging - methods Male Original Paper Paraffin Embedding Postmortem Changes Predictive Value of Tests Risk Factors Thromboembolism - pathology |
| title | Comparison of 7.0-T T2-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates |
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