The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro
Background: Tamoxifen (TAM) and toremifene (TOR) prevent estrogen from stimulating breast cancer growth and also have agonistic effects in a number of physiological systems. TAM is known to increase intracellular triglyceride, but the action of TOR on lipid metabolism in vitro has not yet been deter...
Gespeichert in:
| Veröffentlicht in: | Gynecologic and obstetric investigation 2011-01, Vol.71 (3), p.213-216 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 216 |
|---|---|
| container_issue | 3 |
| container_start_page | 213 |
| container_title | Gynecologic and obstetric investigation |
| container_volume | 71 |
| creator | Sawaki, Masataka Idota, Ai Uchida, Hiroki Noda, Sumiyo Sato, Shigenori Kikumori, Toyone Imai, Tsuneo |
| description | Background: Tamoxifen (TAM) and toremifene (TOR) prevent estrogen from stimulating breast cancer growth and also have agonistic effects in a number of physiological systems. TAM is known to increase intracellular triglyceride, but the action of TOR on lipid metabolism in vitro has not yet been determined. Aim: To compare the effect of TOR on lipid metabolism with that of TAM in vitro, using HepG2 cell lines. Methods: Intracellular concentrations of total cholesterol and triglyceride in HepG2 cells were measured by an enzymatic method after TAM or TOR treatment. Results: Intracellular concentrations of total cholesterol were decreased by both TAM and TOR, but not significantly different from the control level. TOR produced no changes in the intracellular concentrations of triglyceride, whereas TAM increased the intracellular concentrations of triglyceride at concentrations ranging from 10 –7 to 10 –5 mol/l of TAM (p < 0.05). Moreover, significant differences were noted between the two treated groups at concentrations ranging from 10 –9 to 10 –5 mol/l (p < 0.05). Conclusion: TOR treatment did not increase intracellular concentrations of triglyceride, although TAM treatment did so. |
| doi_str_mv | 10.1159/000322372 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000322372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>863427144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-a9e4f222c36bb663ced3e0c359e09c217d199cd96500cfd66ff79e677a07e7aa3</originalsourceid><addsrcrecordid>eNpd0ElLAzEUB_Agitbl4F0kCCIeRrM1aY5S6gIVLxW8DWnmxUZnJjWZunx7I60VPD0e_N7CH6FDSi4o7etLQghnjCu2gXpUMF4Qwp42UY9wNSgUF3IH7ab0QkjGA7GNdhilWkote-hxMgM8cg5sh4PDkxCh8Q5awKHFYz_3Fb6HzkxD7VODh6GZmwgV_vDdDE9mZjlkmvD5M4R9i999F8M-2nKmTnCwqnvo8Xo0Gd4W44ebu-HVuLBcsq4wGoRjjOVuOpWSW6g4EMv7Goi2jKqKam0rLfuEWFdJ6ZzSIJUyRIEyhu-hs-XeeQxvC0hd2fhkoa5NC2GRyoHkgikqRJYn_-RLWMQ2P5eR0JpTMsjofIlsDClFcOU8-sbEr5KS8ifpcp10tserhYtpA9Va_kabwekKmGRN7aJprU9_TlAuhKLZHS3dq4nPENdgdecbGVKM1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>864993108</pqid></control><display><type>article</type><title>The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro</title><source>MEDLINE</source><source>Karger Journals</source><source>Alma/SFX Local Collection</source><creator>Sawaki, Masataka ; Idota, Ai ; Uchida, Hiroki ; Noda, Sumiyo ; Sato, Shigenori ; Kikumori, Toyone ; Imai, Tsuneo</creator><creatorcontrib>Sawaki, Masataka ; Idota, Ai ; Uchida, Hiroki ; Noda, Sumiyo ; Sato, Shigenori ; Kikumori, Toyone ; Imai, Tsuneo</creatorcontrib><description>Background: Tamoxifen (TAM) and toremifene (TOR) prevent estrogen from stimulating breast cancer growth and also have agonistic effects in a number of physiological systems. TAM is known to increase intracellular triglyceride, but the action of TOR on lipid metabolism in vitro has not yet been determined. Aim: To compare the effect of TOR on lipid metabolism with that of TAM in vitro, using HepG2 cell lines. Methods: Intracellular concentrations of total cholesterol and triglyceride in HepG2 cells were measured by an enzymatic method after TAM or TOR treatment. Results: Intracellular concentrations of total cholesterol were decreased by both TAM and TOR, but not significantly different from the control level. TOR produced no changes in the intracellular concentrations of triglyceride, whereas TAM increased the intracellular concentrations of triglyceride at concentrations ranging from 10 –7 to 10 –5 mol/l of TAM (p < 0.05). Moreover, significant differences were noted between the two treated groups at concentrations ranging from 10 –9 to 10 –5 mol/l (p < 0.05). Conclusion: TOR treatment did not increase intracellular concentrations of triglyceride, although TAM treatment did so.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000322372</identifier><identifier>PMID: 21196696</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Biological and medical sciences ; Cholesterol - metabolism ; Gynecology. Andrology. Obstetrics ; Hep G2 Cells ; Humans ; Lipid Metabolism - drug effects ; Mammary gland diseases ; Medical sciences ; Original Article ; Selective Estrogen Receptor Modulators - pharmacology ; Tamoxifen - pharmacology ; Toremifene - pharmacology ; Triglycerides - metabolism ; Tumors</subject><ispartof>Gynecologic and obstetric investigation, 2011-01, Vol.71 (3), p.213-216</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-a9e4f222c36bb663ced3e0c359e09c217d199cd96500cfd66ff79e677a07e7aa3</citedby><cites>FETCH-LOGICAL-c362t-a9e4f222c36bb663ced3e0c359e09c217d199cd96500cfd66ff79e677a07e7aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2425,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24134471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21196696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawaki, Masataka</creatorcontrib><creatorcontrib>Idota, Ai</creatorcontrib><creatorcontrib>Uchida, Hiroki</creatorcontrib><creatorcontrib>Noda, Sumiyo</creatorcontrib><creatorcontrib>Sato, Shigenori</creatorcontrib><creatorcontrib>Kikumori, Toyone</creatorcontrib><creatorcontrib>Imai, Tsuneo</creatorcontrib><title>The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>Background: Tamoxifen (TAM) and toremifene (TOR) prevent estrogen from stimulating breast cancer growth and also have agonistic effects in a number of physiological systems. TAM is known to increase intracellular triglyceride, but the action of TOR on lipid metabolism in vitro has not yet been determined. Aim: To compare the effect of TOR on lipid metabolism with that of TAM in vitro, using HepG2 cell lines. Methods: Intracellular concentrations of total cholesterol and triglyceride in HepG2 cells were measured by an enzymatic method after TAM or TOR treatment. Results: Intracellular concentrations of total cholesterol were decreased by both TAM and TOR, but not significantly different from the control level. TOR produced no changes in the intracellular concentrations of triglyceride, whereas TAM increased the intracellular concentrations of triglyceride at concentrations ranging from 10 –7 to 10 –5 mol/l of TAM (p < 0.05). Moreover, significant differences were noted between the two treated groups at concentrations ranging from 10 –9 to 10 –5 mol/l (p < 0.05). Conclusion: TOR treatment did not increase intracellular concentrations of triglyceride, although TAM treatment did so.</description><subject>Biological and medical sciences</subject><subject>Cholesterol - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Lipid Metabolism - drug effects</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Original Article</subject><subject>Selective Estrogen Receptor Modulators - pharmacology</subject><subject>Tamoxifen - pharmacology</subject><subject>Toremifene - pharmacology</subject><subject>Triglycerides - metabolism</subject><subject>Tumors</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0ElLAzEUB_Agitbl4F0kCCIeRrM1aY5S6gIVLxW8DWnmxUZnJjWZunx7I60VPD0e_N7CH6FDSi4o7etLQghnjCu2gXpUMF4Qwp42UY9wNSgUF3IH7ab0QkjGA7GNdhilWkote-hxMgM8cg5sh4PDkxCh8Q5awKHFYz_3Fb6HzkxD7VODh6GZmwgV_vDdDE9mZjlkmvD5M4R9i999F8M-2nKmTnCwqnvo8Xo0Gd4W44ebu-HVuLBcsq4wGoRjjOVuOpWSW6g4EMv7Goi2jKqKam0rLfuEWFdJ6ZzSIJUyRIEyhu-hs-XeeQxvC0hd2fhkoa5NC2GRyoHkgikqRJYn_-RLWMQ2P5eR0JpTMsjofIlsDClFcOU8-sbEr5KS8ifpcp10tserhYtpA9Va_kabwekKmGRN7aJprU9_TlAuhKLZHS3dq4nPENdgdecbGVKM1Q</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Sawaki, Masataka</creator><creator>Idota, Ai</creator><creator>Uchida, Hiroki</creator><creator>Noda, Sumiyo</creator><creator>Sato, Shigenori</creator><creator>Kikumori, Toyone</creator><creator>Imai, Tsuneo</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro</title><author>Sawaki, Masataka ; Idota, Ai ; Uchida, Hiroki ; Noda, Sumiyo ; Sato, Shigenori ; Kikumori, Toyone ; Imai, Tsuneo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-a9e4f222c36bb663ced3e0c359e09c217d199cd96500cfd66ff79e677a07e7aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Cholesterol - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Lipid Metabolism - drug effects</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Original Article</topic><topic>Selective Estrogen Receptor Modulators - pharmacology</topic><topic>Tamoxifen - pharmacology</topic><topic>Toremifene - pharmacology</topic><topic>Triglycerides - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawaki, Masataka</creatorcontrib><creatorcontrib>Idota, Ai</creatorcontrib><creatorcontrib>Uchida, Hiroki</creatorcontrib><creatorcontrib>Noda, Sumiyo</creatorcontrib><creatorcontrib>Sato, Shigenori</creatorcontrib><creatorcontrib>Kikumori, Toyone</creatorcontrib><creatorcontrib>Imai, Tsuneo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic and obstetric investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawaki, Masataka</au><au>Idota, Ai</au><au>Uchida, Hiroki</au><au>Noda, Sumiyo</au><au>Sato, Shigenori</au><au>Kikumori, Toyone</au><au>Imai, Tsuneo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro</atitle><jtitle>Gynecologic and obstetric investigation</jtitle><addtitle>Gynecol Obstet Invest</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>71</volume><issue>3</issue><spage>213</spage><epage>216</epage><pages>213-216</pages><issn>0378-7346</issn><eissn>1423-002X</eissn><coden>GOBIDS</coden><abstract>Background: Tamoxifen (TAM) and toremifene (TOR) prevent estrogen from stimulating breast cancer growth and also have agonistic effects in a number of physiological systems. TAM is known to increase intracellular triglyceride, but the action of TOR on lipid metabolism in vitro has not yet been determined. Aim: To compare the effect of TOR on lipid metabolism with that of TAM in vitro, using HepG2 cell lines. Methods: Intracellular concentrations of total cholesterol and triglyceride in HepG2 cells were measured by an enzymatic method after TAM or TOR treatment. Results: Intracellular concentrations of total cholesterol were decreased by both TAM and TOR, but not significantly different from the control level. TOR produced no changes in the intracellular concentrations of triglyceride, whereas TAM increased the intracellular concentrations of triglyceride at concentrations ranging from 10 –7 to 10 –5 mol/l of TAM (p < 0.05). Moreover, significant differences were noted between the two treated groups at concentrations ranging from 10 –9 to 10 –5 mol/l (p < 0.05). Conclusion: TOR treatment did not increase intracellular concentrations of triglyceride, although TAM treatment did so.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21196696</pmid><doi>10.1159/000322372</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-7346 |
| ispartof | Gynecologic and obstetric investigation, 2011-01, Vol.71 (3), p.213-216 |
| issn | 0378-7346 1423-002X |
| language | eng |
| recordid | cdi_crossref_primary_10_1159_000322372 |
| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cholesterol - metabolism Gynecology. Andrology. Obstetrics Hep G2 Cells Humans Lipid Metabolism - drug effects Mammary gland diseases Medical sciences Original Article Selective Estrogen Receptor Modulators - pharmacology Tamoxifen - pharmacology Toremifene - pharmacology Triglycerides - metabolism Tumors |
| title | The Effect of Toremifene on Lipid Metabolism Compared with That of Tamoxifen in vitro |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T06%3A38%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Toremifene%20on%20Lipid%20Metabolism%20Compared%20with%20That%20of%20Tamoxifen%20in%20vitro&rft.jtitle=Gynecologic%20and%20obstetric%20investigation&rft.au=Sawaki,%20Masataka&rft.date=2011-01-01&rft.volume=71&rft.issue=3&rft.spage=213&rft.epage=216&rft.pages=213-216&rft.issn=0378-7346&rft.eissn=1423-002X&rft.coden=GOBIDS&rft_id=info:doi/10.1159/000322372&rft_dat=%3Cproquest_cross%3E863427144%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=864993108&rft_id=info:pmid/21196696&rfr_iscdi=true |