Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders
Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis fact...
Gespeichert in:
Veröffentlicht in: | Neuropsychobiology 2011-01, Vol.63 (1), p.8-14 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 14 |
---|---|
container_issue | 1 |
container_start_page | 8 |
container_title | Neuropsychobiology |
container_volume | 63 |
creator | Ahrén-Moonga, Jennie Lekander, Mats von Blixen, Nils Rönnelid, Johan Holmgren, Sven af Klinteberg, Britt |
description | Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in ED patients, and to explore possible relationships between cytokines and self-reported personality traits. Methods: Female patients with severe ED (n = 26) were recruited consecutively from an inpatient clinic and were compared to age-matched healthy females (n = 12). Commercial ELISA tests developed for the measurement of serum levels of TNF-α and IL-6 were employed. Personality traits were measured using Karolinska Scales of Personality. Results: The patient group displayed increased levels of the cytokine TNF-α and a tendency towards increased IL-6 levels. Spearman’s rank correlation coefficient was used to examine possible relationships between levels of cytokines and personality traits. The results showed that IL-6 levels were positively related to both somatic and psychic anxiety and to aggression scales, such as irritability and suspicion. Increased levels of TNF-α, in turn, were significantly correlated with high scores on the depression-related anxiety scale Inhibition of Aggression. However, increased levels of cytokines in the ED group did not seem to be mainly associated with symptoms of depression. Conclusion: We cannot rule out the possibility that comorbid conditions in the group contribute to the higher cytokine values. Further studies need to explore the possible influence of cytokines on the severity of ED and whether this might be mediated or moderated by specific personality traits. |
doi_str_mv | 10.1159/000321832 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000321832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2195179131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c525t-ebc829af7af58f2bb5af96b505ee87c9c79b282dbd8e3d6652f4c29f4936e4ab3</originalsourceid><addsrcrecordid>eNqF0s9rFDEUB_AgFruuHryLhF5EdDR5k8wkx6U_7MKiglW8hczMm226szNrMrH0vzfLblcQSk_5wecbXniPkFecfeRc6k-MsRy4yuEJmXABecYAxFMyYTmDDBT8OibPQ7hhjAtd6mfkGJguQAqYkOUC_2AX6NDSq7geoqdfsPZDcIFe2HocfDbrNteW2r6h835E32FcuT4rqOvp95T12N3RedfRb3Z02I-B3rrxmp6nU7-kZy4MvkEfXpCj1nYBX-7XKflxcX51epktvn6en84WWS1BjhlWtQJt29K2UrVQVdK2uqgkk4iqrHVd6ip9qKkahXlTFBJaUYNuhc4LFLbKpyTbvRtucRMrs_Fubf2dGawz-6tV2qGRQoHSyesH_cYPzb_QfZADl0qJkqXshwezZ-7nzAx-aWI0PJc5FIm_f5yHaHKhUi-n5O1Opyp-RwyjWbtQY9fZHocYjJZC6kJD-ahUTAlZSr4t-OQ_eZM63qd-JFRqxtK_Enq3Q9sxCB7bQ6Gcme24mcO4Jftm_2Cs1tgc5P18JfB6B1bWL9EfwD7_F8_p2cQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>807900884</pqid></control><display><type>article</type><title>Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders</title><source>MEDLINE</source><source>Karger_医学期刊</source><source>Alma/SFX Local Collection</source><creator>Ahrén-Moonga, Jennie ; Lekander, Mats ; von Blixen, Nils ; Rönnelid, Johan ; Holmgren, Sven ; af Klinteberg, Britt</creator><creatorcontrib>Ahrén-Moonga, Jennie ; Lekander, Mats ; von Blixen, Nils ; Rönnelid, Johan ; Holmgren, Sven ; af Klinteberg, Britt</creatorcontrib><description>Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in ED patients, and to explore possible relationships between cytokines and self-reported personality traits. Methods: Female patients with severe ED (n = 26) were recruited consecutively from an inpatient clinic and were compared to age-matched healthy females (n = 12). Commercial ELISA tests developed for the measurement of serum levels of TNF-α and IL-6 were employed. Personality traits were measured using Karolinska Scales of Personality. Results: The patient group displayed increased levels of the cytokine TNF-α and a tendency towards increased IL-6 levels. Spearman’s rank correlation coefficient was used to examine possible relationships between levels of cytokines and personality traits. The results showed that IL-6 levels were positively related to both somatic and psychic anxiety and to aggression scales, such as irritability and suspicion. Increased levels of TNF-α, in turn, were significantly correlated with high scores on the depression-related anxiety scale Inhibition of Aggression. However, increased levels of cytokines in the ED group did not seem to be mainly associated with symptoms of depression. Conclusion: We cannot rule out the possibility that comorbid conditions in the group contribute to the higher cytokine values. Further studies need to explore the possible influence of cytokines on the severity of ED and whether this might be mediated or moderated by specific personality traits.</description><identifier>ISSN: 0302-282X</identifier><identifier>ISSN: 1423-0224</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000321832</identifier><identifier>PMID: 20962542</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adult ; Aggression ; Anxiety ; Cytokines ; Depression ; Eating disorders ; Enzyme-linked immunosorbent assay ; Feeding and Eating Disorders - blood ; Feeding and Eating Disorders - psychology ; Female ; Humans ; Inflammation ; Interleukin 6 ; Interleukin-6 - blood ; Karolinska Scales of Personality ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Original Paper ; Personality ; Personality Assessment ; Personality traits ; Psychology ; Psykologi ; SAMHÄLLSVETENSKAP ; Self Report ; Serum levels ; SOCIAL SCIENCES ; Socialvetenskap ; tumor necrosis ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Neuropsychobiology, 2011-01, Vol.63 (1), p.8-14</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-ebc829af7af58f2bb5af96b505ee87c9c79b282dbd8e3d6652f4c29f4936e4ab3</citedby><cites>FETCH-LOGICAL-c525t-ebc829af7af58f2bb5af96b505ee87c9c79b282dbd8e3d6652f4c29f4936e4ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20962542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-34818$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135326$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:121588470$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahrén-Moonga, Jennie</creatorcontrib><creatorcontrib>Lekander, Mats</creatorcontrib><creatorcontrib>von Blixen, Nils</creatorcontrib><creatorcontrib>Rönnelid, Johan</creatorcontrib><creatorcontrib>Holmgren, Sven</creatorcontrib><creatorcontrib>af Klinteberg, Britt</creatorcontrib><title>Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders</title><title>Neuropsychobiology</title><addtitle>Neuropsychobiology</addtitle><description>Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in ED patients, and to explore possible relationships between cytokines and self-reported personality traits. Methods: Female patients with severe ED (n = 26) were recruited consecutively from an inpatient clinic and were compared to age-matched healthy females (n = 12). Commercial ELISA tests developed for the measurement of serum levels of TNF-α and IL-6 were employed. Personality traits were measured using Karolinska Scales of Personality. Results: The patient group displayed increased levels of the cytokine TNF-α and a tendency towards increased IL-6 levels. Spearman’s rank correlation coefficient was used to examine possible relationships between levels of cytokines and personality traits. The results showed that IL-6 levels were positively related to both somatic and psychic anxiety and to aggression scales, such as irritability and suspicion. Increased levels of TNF-α, in turn, were significantly correlated with high scores on the depression-related anxiety scale Inhibition of Aggression. However, increased levels of cytokines in the ED group did not seem to be mainly associated with symptoms of depression. Conclusion: We cannot rule out the possibility that comorbid conditions in the group contribute to the higher cytokine values. Further studies need to explore the possible influence of cytokines on the severity of ED and whether this might be mediated or moderated by specific personality traits.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aggression</subject><subject>Anxiety</subject><subject>Cytokines</subject><subject>Depression</subject><subject>Eating disorders</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Feeding and Eating Disorders - blood</subject><subject>Feeding and Eating Disorders - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Karolinska Scales of Personality</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Original Paper</subject><subject>Personality</subject><subject>Personality Assessment</subject><subject>Personality traits</subject><subject>Psychology</subject><subject>Psykologi</subject><subject>SAMHÄLLSVETENSKAP</subject><subject>Self Report</subject><subject>Serum levels</subject><subject>SOCIAL SCIENCES</subject><subject>Socialvetenskap</subject><subject>tumor necrosis</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0302-282X</issn><issn>1423-0224</issn><issn>1423-0224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0s9rFDEUB_AgFruuHryLhF5EdDR5k8wkx6U_7MKiglW8hczMm226szNrMrH0vzfLblcQSk_5wecbXniPkFecfeRc6k-MsRy4yuEJmXABecYAxFMyYTmDDBT8OibPQ7hhjAtd6mfkGJguQAqYkOUC_2AX6NDSq7geoqdfsPZDcIFe2HocfDbrNteW2r6h835E32FcuT4rqOvp95T12N3RedfRb3Z02I-B3rrxmp6nU7-kZy4MvkEfXpCj1nYBX-7XKflxcX51epktvn6en84WWS1BjhlWtQJt29K2UrVQVdK2uqgkk4iqrHVd6ip9qKkahXlTFBJaUYNuhc4LFLbKpyTbvRtucRMrs_Fubf2dGawz-6tV2qGRQoHSyesH_cYPzb_QfZADl0qJkqXshwezZ-7nzAx-aWI0PJc5FIm_f5yHaHKhUi-n5O1Opyp-RwyjWbtQY9fZHocYjJZC6kJD-ahUTAlZSr4t-OQ_eZM63qd-JFRqxtK_Enq3Q9sxCB7bQ6Gcme24mcO4Jftm_2Cs1tgc5P18JfB6B1bWL9EfwD7_F8_p2cQ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Ahrén-Moonga, Jennie</creator><creator>Lekander, Mats</creator><creator>von Blixen, Nils</creator><creator>Rönnelid, Johan</creator><creator>Holmgren, Sven</creator><creator>af Klinteberg, Britt</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG7</scope><scope>DF2</scope></search><sort><creationdate>20110101</creationdate><title>Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders</title><author>Ahrén-Moonga, Jennie ; Lekander, Mats ; von Blixen, Nils ; Rönnelid, Johan ; Holmgren, Sven ; af Klinteberg, Britt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-ebc829af7af58f2bb5af96b505ee87c9c79b282dbd8e3d6652f4c29f4936e4ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aggression</topic><topic>Anxiety</topic><topic>Cytokines</topic><topic>Depression</topic><topic>Eating disorders</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Feeding and Eating Disorders - blood</topic><topic>Feeding and Eating Disorders - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Karolinska Scales of Personality</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Original Paper</topic><topic>Personality</topic><topic>Personality Assessment</topic><topic>Personality traits</topic><topic>Psychology</topic><topic>Psykologi</topic><topic>SAMHÄLLSVETENSKAP</topic><topic>Self Report</topic><topic>Serum levels</topic><topic>SOCIAL SCIENCES</topic><topic>Socialvetenskap</topic><topic>tumor necrosis</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahrén-Moonga, Jennie</creatorcontrib><creatorcontrib>Lekander, Mats</creatorcontrib><creatorcontrib>von Blixen, Nils</creatorcontrib><creatorcontrib>Rönnelid, Johan</creatorcontrib><creatorcontrib>Holmgren, Sven</creatorcontrib><creatorcontrib>af Klinteberg, Britt</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Stockholms universitet</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahrén-Moonga, Jennie</au><au>Lekander, Mats</au><au>von Blixen, Nils</au><au>Rönnelid, Johan</au><au>Holmgren, Sven</au><au>af Klinteberg, Britt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>63</volume><issue>1</issue><spage>8</spage><epage>14</epage><pages>8-14</pages><issn>0302-282X</issn><issn>1423-0224</issn><eissn>1423-0224</eissn><abstract>Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in ED patients, and to explore possible relationships between cytokines and self-reported personality traits. Methods: Female patients with severe ED (n = 26) were recruited consecutively from an inpatient clinic and were compared to age-matched healthy females (n = 12). Commercial ELISA tests developed for the measurement of serum levels of TNF-α and IL-6 were employed. Personality traits were measured using Karolinska Scales of Personality. Results: The patient group displayed increased levels of the cytokine TNF-α and a tendency towards increased IL-6 levels. Spearman’s rank correlation coefficient was used to examine possible relationships between levels of cytokines and personality traits. The results showed that IL-6 levels were positively related to both somatic and psychic anxiety and to aggression scales, such as irritability and suspicion. Increased levels of TNF-α, in turn, were significantly correlated with high scores on the depression-related anxiety scale Inhibition of Aggression. However, increased levels of cytokines in the ED group did not seem to be mainly associated with symptoms of depression. Conclusion: We cannot rule out the possibility that comorbid conditions in the group contribute to the higher cytokine values. Further studies need to explore the possible influence of cytokines on the severity of ED and whether this might be mediated or moderated by specific personality traits.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20962542</pmid><doi>10.1159/000321832</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0302-282X |
ispartof | Neuropsychobiology, 2011-01, Vol.63 (1), p.8-14 |
issn | 0302-282X 1423-0224 1423-0224 |
language | eng |
recordid | cdi_crossref_primary_10_1159_000321832 |
source | MEDLINE; Karger_医学期刊; Alma/SFX Local Collection |
subjects | Adolescent Adult Aggression Anxiety Cytokines Depression Eating disorders Enzyme-linked immunosorbent assay Feeding and Eating Disorders - blood Feeding and Eating Disorders - psychology Female Humans Inflammation Interleukin 6 Interleukin-6 - blood Karolinska Scales of Personality MEDICIN Medicin och hälsovetenskap MEDICINE Original Paper Personality Personality Assessment Personality traits Psychology Psykologi SAMHÄLLSVETENSKAP Self Report Serum levels SOCIAL SCIENCES Socialvetenskap tumor necrosis Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - blood |
title | Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A26%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Levels%20of%20Tumour%20Necrosis%20Factor-Alpha%20and%20Interleukin-6%20in%20Severely%20Ill%20Patients%20with%20Eating%20Disorders&rft.jtitle=Neuropsychobiology&rft.au=Ahr%C3%A9n-Moonga,%20Jennie&rft.date=2011-01-01&rft.volume=63&rft.issue=1&rft.spage=8&rft.epage=14&rft.pages=8-14&rft.issn=0302-282X&rft.eissn=1423-0224&rft_id=info:doi/10.1159/000321832&rft_dat=%3Cproquest_cross%3E2195179131%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=807900884&rft_id=info:pmid/20962542&rfr_iscdi=true |