Hemeoxygenase-1 and Renal Ischaemia-Reperfusion Injury

Degradation by the inducible enzyme hemeoxygenase-1 (HO-1) is the principal route of mammalian heme metabolism. The resultant generation of free iron, carbon monoxide and biliverdin results in myriad actions including promoting cell survival, circulatory integrity and immunomodulation. This review e...

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Veröffentlicht in:	Nephron 2010-01, Vol.115 (3), p.e33-e37
Hauptverfasser:	Ferenbach, David A., Kluth, David C., Hughes, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Animals Apoptosis - drug effects Biliverdine - metabolism Carbon Monoxide - physiology Heme Oxygenase-1 - antagonists & inhibitors Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans Kidney - enzymology Kidney - immunology Minireview Reperfusion Injury - enzymology Up-Regulation
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