The Long and Winding Road to Useful Predictive Factors for Anti-EGFR Therapy in Metastatic Colorectal Carcinoma: The KRAS/BRAF Pathway

Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with metastatic colorectal carcinoma. Among patients not carrying activating mutations in the KRAS gene, only a limited number will experience tumor response to these therapeutic agents. T...

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Veröffentlicht in:	Oncology 2009-01, Vol.77 (Suppl 1), p.57-68
Hauptverfasser:	Russo, Antonio, Rizzo, Sergio, Bronte, Giuseppe, Silvestris, Nicola, Colucci, Giuseppe, Gebbia, Nicola, Bazan, Viviana, Fulfaro, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Clinical Trials as Topic Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Mutation - genetics Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Receptor, Epidermal Growth Factor - antagonists & inhibitors Signal Transduction - drug effects Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
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