Characterization of Two Models of Drug-Induced Constipation in Mice and Evaluation of Mustard Oil in These Models

Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized. Therefore, the aims of this study were to validate the clonidine- and loperamide-induced delays of colonic tran...

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Veröffentlicht in:	Pharmacology 2009-01, Vol.84 (4), p.227-233
Hauptverfasser:	Kojima, Ryosuke, Doihara, Hitoshi, Nozawa, Katsura, Kawabata-Shoda, Eri, Yokoyama, Toshihide, Ito, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Clonidine Constipation - chemically induced Constipation - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions Gastrointestinal Transit - drug effects Indoles - pharmacology Loperamide Male Mice Mice, Inbred Strains Mustard Plant Naloxone - pharmacology Original Paper Plant Oils - therapeutic use Transient Receptor Potential Channels - agonists TRPA1 Cation Channel Yohimbine - pharmacology
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