Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica
Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jam...
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| Veröffentlicht in: | Intervirology 2009-01, Vol.52 (3), p.115-122 |
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| creator | Umeki, Kazumi Hisada, Michie Maloney, Elizabeth M. Hanchard, Barrie Okayama, Akihiko |
| description | Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1-infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored. |
| doi_str_mv | 10.1159/000219384 |
| format | Article |
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Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1-infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored.</description><identifier>ISSN: 0300-5526</identifier><identifier>EISSN: 1423-0100</identifier><identifier>DOI: 10.1159/000219384</identifier><identifier>PMID: 19468234</identifier><identifier>CODEN: IVRYAK</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Child ; Child, Preschool ; DNA Fingerprinting ; DNA, Viral - genetics ; Female ; HTLV-I Infections - transmission ; HTLV-I Infections - virology ; Human T-lymphotropic virus 1 - classification ; Human T-lymphotropic virus 1 - genetics ; Human T-lymphotropic virus 1 - isolation & purification ; Humans ; Infant ; Jamaica ; Leukocytes, Mononuclear - virology ; Longitudinal Studies ; Original Paper ; Polymerase Chain Reaction - methods ; Proviruses - classification ; Proviruses - genetics ; Proviruses - isolation & purification ; Viral Load</subject><ispartof>Intervirology, 2009-01, Vol.52 (3), p.115-122</ispartof><rights>2009 S. Karger AG, Basel</rights><rights>Copyright 2009 S. Karger AG, Basel.</rights><rights>Copyright (c) 2009 S. Karger AG, Basel</rights><rights>Copyright © 2009 by S. Karger AG, Basel 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-ecfc066fa8431290049805b5b87adaaa1dcf524b9e8abc58bfe4a606a73cc9c43</citedby><cites>FETCH-LOGICAL-c487t-ecfc066fa8431290049805b5b87adaaa1dcf524b9e8abc58bfe4a606a73cc9c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19468234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Umeki, Kazumi</creatorcontrib><creatorcontrib>Hisada, Michie</creatorcontrib><creatorcontrib>Maloney, Elizabeth M.</creatorcontrib><creatorcontrib>Hanchard, Barrie</creatorcontrib><creatorcontrib>Okayama, Akihiko</creatorcontrib><title>Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica</title><title>Intervirology</title><addtitle>Intervirology</addtitle><description>Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1-infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA Fingerprinting</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>HTLV-I Infections - transmission</subject><subject>HTLV-I Infections - virology</subject><subject>Human T-lymphotropic virus 1 - classification</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Humans</subject><subject>Infant</subject><subject>Jamaica</subject><subject>Leukocytes, Mononuclear - virology</subject><subject>Longitudinal Studies</subject><subject>Original Paper</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Proviruses - classification</subject><subject>Proviruses - genetics</subject><subject>Proviruses - isolation & purification</subject><subject>Viral Load</subject><issn>0300-5526</issn><issn>1423-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1vEzEQhi1ERUPhwB0hqwckDobx2rvr5VCpivqpSHBIK3GyZr3e1GVjB3tT4B_ws3GaKHycRpp53lcz8xLyisN7zsvmAwAUvBFKPiETLgvBgAM8JRMQAKwsi-qQPE_pPmOCC3hGDnkjK1UIOSG_Psfw4CIOdBawSxR9R6dD8Llx9mOFPrngaejp5Xx2yzi78r01o82MHYZE-zAM4bvzC3pr4-hMVs1jFi1d2gg_0lPKgX2xGOn5I8puVhu36Z0bumg9dZ5e4xKz8gU56HFI9uWuHpGb87P59JLNPl1cTU9nzEhVj8ya3kBV9aik4EUDIBsFZVu2qsYOEXln-rKQbWMVtqZUbW8lVlBhLYxpjBRH5GTru1q3S9sZ68d8vV5Ft8T4Uwd0-t-Jd3d6ER50UTdQl5AN3u4MYvi2tmnU-VqT34HehnXSVS25aiqVweP_wPuwjvmzSRcguZBQ8gy920ImhpSi7febcNCbcPU-3My--Xv1P-QuzQy83gJfMS5s3AM7_W-6pKi6</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Umeki, Kazumi</creator><creator>Hisada, Michie</creator><creator>Maloney, Elizabeth M.</creator><creator>Hanchard, Barrie</creator><creator>Okayama, Akihiko</creator><general>S. 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genetics</topic><topic>Female</topic><topic>HTLV-I Infections - transmission</topic><topic>HTLV-I Infections - virology</topic><topic>Human T-lymphotropic virus 1 - classification</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Human T-lymphotropic virus 1 - isolation & purification</topic><topic>Humans</topic><topic>Infant</topic><topic>Jamaica</topic><topic>Leukocytes, Mononuclear - virology</topic><topic>Longitudinal Studies</topic><topic>Original Paper</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Proviruses - classification</topic><topic>Proviruses - genetics</topic><topic>Proviruses - isolation & purification</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umeki, Kazumi</creatorcontrib><creatorcontrib>Hisada, Michie</creatorcontrib><creatorcontrib>Maloney, Elizabeth M.</creatorcontrib><creatorcontrib>Hanchard, Barrie</creatorcontrib><creatorcontrib>Okayama, Akihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Intervirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umeki, Kazumi</au><au>Hisada, Michie</au><au>Maloney, Elizabeth M.</au><au>Hanchard, Barrie</au><au>Okayama, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica</atitle><jtitle>Intervirology</jtitle><addtitle>Intervirology</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>52</volume><issue>3</issue><spage>115</spage><epage>122</epage><pages>115-122</pages><issn>0300-5526</issn><eissn>1423-0100</eissn><coden>IVRYAK</coden><abstract>Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1-infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>19468234</pmid><doi>10.1159/000219384</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Intervirology, 2009-01, Vol.52 (3), p.115-122 |
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| source | Karger电子期刊和电子书数据库; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Child Child, Preschool DNA Fingerprinting DNA, Viral - genetics Female HTLV-I Infections - transmission HTLV-I Infections - virology Human T-lymphotropic virus 1 - classification Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - isolation & purification Humans Infant Jamaica Leukocytes, Mononuclear - virology Longitudinal Studies Original Paper Polymerase Chain Reaction - methods Proviruses - classification Proviruses - genetics Proviruses - isolation & purification Viral Load |
| title | Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica |
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