Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans
Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of...
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| Veröffentlicht in: | Human heredity 1996-11, Vol.46 (6), p.301-309 |
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| container_title | Human heredity |
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| creator | Jaquish, C.E. Blangero, J. Haffner, S.M. Stern, M.P. Maccluer, J.W. |
| description | Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL₃ levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans. |
| doi_str_mv | 10.1159/000154368 |
| format | Article |
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We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL₃ levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000154368</identifier><identifier>PMID: 8956025</identifier><identifier>CODEN: HUHEAS</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL₃ levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Mexican Americans</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Original Paper</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Texas</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1v1DAQhi0EKsvCgTtIlkBIHAJ2Phz3WG0_tlIRUOAcTewxuM3GW49T0R_Bf8arXeWAOI1n3sdj62HspRQfpGyOPwohZFNXSj9iC1mXVSGEKh-zxW5eNKopn7JnRDe51aKtjtiRPm6UKJsF-_N1gjH5BMnfI7_AEZM3xIPjp_jrwcaAWw9jrpQwhhH5t2lwkJDnIb9MxK9xyHfDyFPgXwKR7wfkK4jWh3sgMw0Q-aknBEJ-7emWn4NJIRL3I_-Ev72BkZ9sMO4O9Jw9cTAQvjjUJftxfvZ9tS6uPl9crk6uClNpkQoDCL2wFnuhnDIV1tjLxqm26VG5ss-dtspACVL1TSmssaIue2mVa52zulqyd_u92xjuJqTUbTwZHAYYMUzUtVpJoSuRwfd70GQDFNF12-g3EB86Kbqd-m5Wn9nXh6VTv0E7kwfXOX97yLMXGFyE0XiasbJutc6bluzNHruF-BPjnK_XZ_uHuq11mXr1X-rfv9xQlj2ndSOFlK2s_gLY7K1y</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Jaquish, C.E.</creator><creator>Blangero, J.</creator><creator>Haffner, S.M.</creator><creator>Stern, M.P.</creator><creator>Maccluer, J.W.</creator><general>S. 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Psychology</topic><topic>Genetic Variation</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Mexican Americans</topic><topic>Middle Aged</topic><topic>Models, Genetic</topic><topic>Original Paper</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Texas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaquish, C.E.</creatorcontrib><creatorcontrib>Blangero, J.</creatorcontrib><creatorcontrib>Haffner, S.M.</creatorcontrib><creatorcontrib>Stern, M.P.</creatorcontrib><creatorcontrib>Maccluer, J.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaquish, C.E.</au><au>Blangero, J.</au><au>Haffner, S.M.</au><au>Stern, M.P.</au><au>Maccluer, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans</atitle><jtitle>Human heredity</jtitle><addtitle>Hum Hered</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>46</volume><issue>6</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>0001-5652</issn><eissn>1423-0062</eissn><coden>HUHEAS</coden><abstract>Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL₃ levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger</pub><pmid>8956025</pmid><doi>10.1159/000154368</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Biological and medical sciences Cardiovascular Diseases - blood Cardiovascular Diseases - ethnology Cardiovascular Diseases - genetics Classical genetics, quantitative genetics, hybrids Dehydroepiandrosterone Sulfate - blood Female Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Human Humans Male Mexican Americans Middle Aged Models, Genetic Original Paper Risk Factors Sex Factors Texas |
| title | Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans |
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