Primary Hepatosplenic Large B-Cell Lymphoma
Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas lim...
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Veröffentlicht in: | Case reports in gastroenterology 2008-03, Vol.2 (1), p.109-115 |
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creator | Morales-Polanco, M.R. Drijansky-Morgenstern, R. Murillo-Meza, E. Gómez-Morales, E. |
description | Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had |
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It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. 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It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.</description><subject>Hepatosplenic</subject><subject>Large B-cell lymphoma</subject><subject>Primary extranodal lymphoma</subject><subject>Published: March 2008</subject><issn>1662-0631</issn><issn>1662-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkL1PwzAQxS0EoqUwsDNEYkIocGc7jj3SCNpKkUAIZsv1R0lJSeR06X9PS6AwMN3TvZ-e7h4h5wg3iJm6BQCkkGf5ARmiEDQFwfDwjx6Qk65bAghOGR6TAUWuQHI5JNdPsVqZuEmmvjXrpmtr_1HZpDRx4ZNxWvi6TsrNqn1rVuaUHAVTd_7se47I68P9SzFNy8fJrLgrU0spz1PHhZeoWCYynjFPA-fBKjWHgCGTzBtgNARq3Zw65tBCLhgY572SVgRr2IjM-lzXmKVu-wN1Yyr9tWjiQpu4rmztNUg5R84F5CHnqITMFLOcScXBcbtVI3LVZ9nYdF30YZ-HoHfl6X15W_aiZ99338df8se-_Ncunic9oVsX2CdauXFc</recordid><startdate>20080313</startdate><enddate>20080313</enddate><creator>Morales-Polanco, M.R.</creator><creator>Drijansky-Morgenstern, R.</creator><creator>Murillo-Meza, E.</creator><creator>Gómez-Morales, E.</creator><general>Karger Publishers</general><scope>M--</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20080313</creationdate><title>Primary Hepatosplenic Large B-Cell Lymphoma</title><author>Morales-Polanco, M.R. ; Drijansky-Morgenstern, R. ; Murillo-Meza, E. ; Gómez-Morales, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2247-d46e8193565453e2f44fc99b0f1f583ea032ff2cdb2d3d1c07630adee98c6fca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Hepatosplenic</topic><topic>Large B-cell lymphoma</topic><topic>Primary extranodal lymphoma</topic><topic>Published: March 2008</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morales-Polanco, M.R.</creatorcontrib><creatorcontrib>Drijansky-Morgenstern, R.</creatorcontrib><creatorcontrib>Murillo-Meza, E.</creatorcontrib><creatorcontrib>Gómez-Morales, E.</creatorcontrib><collection>Karger Open Access</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case reports in gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morales-Polanco, M.R.</au><au>Drijansky-Morgenstern, R.</au><au>Murillo-Meza, E.</au><au>Gómez-Morales, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Hepatosplenic Large B-Cell Lymphoma</atitle><jtitle>Case reports in gastroenterology</jtitle><addtitle>Case Rep Gastroenterol</addtitle><date>2008-03-13</date><risdate>2008</risdate><volume>2</volume><issue>1</issue><spage>109</spage><epage>115</epage><pages>109-115</pages><issn>1662-0631</issn><eissn>1662-0631</eissn><abstract>Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.</abstract><cop>Basel, Switzerland</cop><pub>Karger Publishers</pub><pmid>21490848</pmid><doi>10.1159/000120757</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Hepatosplenic Large B-cell lymphoma Primary extranodal lymphoma Published: March 2008 |
title | Primary Hepatosplenic Large B-Cell Lymphoma |
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