The Noncompetitive Antagonism of Histamine H1 Receptors Expressed in Chinese Hamster Ovary Cells by Olopatadine Hydrochloride: Its Potency and Molecular Mechanism

Calcium responses to various concentrations of histamine were monitored in Chinese hamster ovary cells stably expressing the human histamine H 1 receptor. The effects of various histamine H 1 receptor antagonists on the dose-response curve for histamine were evaluated. Olopatadine hydrochloride (olo...

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Veröffentlicht in:	Pharmacology 2008, Vol.81 (3), p.266-274
Hauptverfasser:	Matsumoto, Yuichi, Funahashi, Jun, Mori, Kiyotoshi, Hayashi, Kozue, Yano, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Calcium - metabolism Cells, Cultured CHO Cells Cricetinae Cricetulus Dibenzoxepins - chemistry Dibenzoxepins - pharmacology Dose-Response Relationship, Drug Endothelial Cells Histamine - administration & dosage Histamine H1 Antagonists - pharmacology Humans Isomerism Olopatadine Hydrochloride Original Paper Protein Binding Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - metabolism Umbilical Veins
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