Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia
In normal pregnancy, trophoblast (TR) invasion plays a crucial role in remodeling the spiral arteries to develop uteroplacental circulation. Disruption of this invasion is associated with deficient uteroplacental circulation, which can lead to the development of preeclampsia (PE) through abnormal ex...
Gespeichert in:
| Veröffentlicht in: | Gynecologic and obstetric investigation 2008-01, Vol.66 (1), p.27-33 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Gynecologic and obstetric investigation |
| container_volume | 66 |
| creator | Abe, Emiko Matsubara, Keiichi Oka, Keizo Kusanagi, Yasuki Ito, Masaharu |
| description | In normal pregnancy, trophoblast (TR) invasion plays a crucial role in remodeling the spiral arteries to develop uteroplacental circulation. Disruption of this invasion is associated with deficient uteroplacental circulation, which can lead to the development of preeclampsia (PE) through abnormal expression of adhesion molecules in the placenta and high serum causative factors such as cytokines. We aimed to evaluate whether serum factors in PE influence intercellular adhesion molecule-1 (ICAM-1) expression of TRs. ICAM-1 expression of TRs was measured using flow cytometry and immunohistochemistry was performed to examine the localization of tumor necrosis factor-α (TNFα) and ICAM-1 in placentas derived from women with normal pregnancies and women with PE. Sera from PE patients significantly increased ICAM-1 expression on TRs compared to sera from normal pregnant women; this increase was blocked with an antibody to TNFα. TNFα also enhanced ICAM-1 expression on TRs through nuclear factor-ĸB activation. We conclude that ICAM-1 expressed on TRs is involved in PE pathogenesis and is regulated by cytokines. |
| doi_str_mv | 10.1159/000114253 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000114253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1512980311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-91519b7a7749bb55e36c7d99fc1f891060f13829e4aebb19b660a3d617f89bca3</originalsourceid><addsrcrecordid>eNqF0c1LHTEQAPAgFn21HrwXWYQWetg2k8_NUR62FRRLsdDbks2b1dW8zZrsgv73ZvseCr0IgYGZH5NMhpAjoF8BpPlGKQUQTPIdssiRl5Syv7tkQbmuSs2F2ifvU7rLSppK7JF9qBinBviCuOXTGO67HovfeDN5O3ahL0JbnPcjRofe51wsTle3mObKZfDoJo8lFGePQ8T0L5vPdQzDbWi8TWMqur74FRGdt-shdfYDeddan_BwGw_In-9n18uf5cXVj_Pl6UXphKzG0oAE02irtTBNIyVy5fTKmNZBWxmgirbAK2ZQWGyaTJWilq8U6FxunOUH5POm7xDDw4RprNddmmewPYYp1cpwYELrNyHLfyOVUBme_AfvwhT7PETNGNcKKJ27fdkgF0NKEdt6iN3axqcaaD3vp37ZT7bH24ZTs8bVq9wuJINPW2CTs76NtnddenGMSi50Nb_s48bd23iD8bXR5p5nU6yfyg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223761007</pqid></control><display><type>article</type><title>Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia</title><source>Karger Journals</source><source>MEDLINE</source><creator>Abe, Emiko ; Matsubara, Keiichi ; Oka, Keizo ; Kusanagi, Yasuki ; Ito, Masaharu</creator><creatorcontrib>Abe, Emiko ; Matsubara, Keiichi ; Oka, Keizo ; Kusanagi, Yasuki ; Ito, Masaharu</creatorcontrib><description>In normal pregnancy, trophoblast (TR) invasion plays a crucial role in remodeling the spiral arteries to develop uteroplacental circulation. Disruption of this invasion is associated with deficient uteroplacental circulation, which can lead to the development of preeclampsia (PE) through abnormal expression of adhesion molecules in the placenta and high serum causative factors such as cytokines. We aimed to evaluate whether serum factors in PE influence intercellular adhesion molecule-1 (ICAM-1) expression of TRs. ICAM-1 expression of TRs was measured using flow cytometry and immunohistochemistry was performed to examine the localization of tumor necrosis factor-α (TNFα) and ICAM-1 in placentas derived from women with normal pregnancies and women with PE. Sera from PE patients significantly increased ICAM-1 expression on TRs compared to sera from normal pregnant women; this increase was blocked with an antibody to TNFα. TNFα also enhanced ICAM-1 expression on TRs through nuclear factor-ĸB activation. We conclude that ICAM-1 expressed on TRs is involved in PE pathogenesis and is regulated by cytokines.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000114253</identifier><identifier>PMID: 18230913</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Female ; Flow Cytometry ; Gene Expression ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Intercellular Adhesion Molecule-1 - biosynthesis ; Medical sciences ; Original Article ; Pre-Eclampsia - genetics ; Pre-Eclampsia - metabolism ; Pregnancy ; Pregnancy. Fetus. Placenta ; Trophoblasts - metabolism ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Gynecologic and obstetric investigation, 2008-01, Vol.66 (1), p.27-33</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-91519b7a7749bb55e36c7d99fc1f891060f13829e4aebb19b660a3d617f89bca3</citedby><cites>FETCH-LOGICAL-c458t-91519b7a7749bb55e36c7d99fc1f891060f13829e4aebb19b660a3d617f89bca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20534786$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18230913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Emiko</creatorcontrib><creatorcontrib>Matsubara, Keiichi</creatorcontrib><creatorcontrib>Oka, Keizo</creatorcontrib><creatorcontrib>Kusanagi, Yasuki</creatorcontrib><creatorcontrib>Ito, Masaharu</creatorcontrib><title>Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>In normal pregnancy, trophoblast (TR) invasion plays a crucial role in remodeling the spiral arteries to develop uteroplacental circulation. Disruption of this invasion is associated with deficient uteroplacental circulation, which can lead to the development of preeclampsia (PE) through abnormal expression of adhesion molecules in the placenta and high serum causative factors such as cytokines. We aimed to evaluate whether serum factors in PE influence intercellular adhesion molecule-1 (ICAM-1) expression of TRs. ICAM-1 expression of TRs was measured using flow cytometry and immunohistochemistry was performed to examine the localization of tumor necrosis factor-α (TNFα) and ICAM-1 in placentas derived from women with normal pregnancies and women with PE. Sera from PE patients significantly increased ICAM-1 expression on TRs compared to sera from normal pregnant women; this increase was blocked with an antibody to TNFα. TNFα also enhanced ICAM-1 expression on TRs through nuclear factor-ĸB activation. We conclude that ICAM-1 expressed on TRs is involved in PE pathogenesis and is regulated by cytokines.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gene Expression</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intercellular Adhesion Molecule-1 - biosynthesis</subject><subject>Medical sciences</subject><subject>Original Article</subject><subject>Pre-Eclampsia - genetics</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Trophoblasts - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c1LHTEQAPAgFn21HrwXWYQWetg2k8_NUR62FRRLsdDbks2b1dW8zZrsgv73ZvseCr0IgYGZH5NMhpAjoF8BpPlGKQUQTPIdssiRl5Syv7tkQbmuSs2F2ifvU7rLSppK7JF9qBinBviCuOXTGO67HovfeDN5O3ahL0JbnPcjRofe51wsTle3mObKZfDoJo8lFGePQ8T0L5vPdQzDbWi8TWMqur74FRGdt-shdfYDeddan_BwGw_In-9n18uf5cXVj_Pl6UXphKzG0oAE02irtTBNIyVy5fTKmNZBWxmgirbAK2ZQWGyaTJWilq8U6FxunOUH5POm7xDDw4RprNddmmewPYYp1cpwYELrNyHLfyOVUBme_AfvwhT7PETNGNcKKJ27fdkgF0NKEdt6iN3axqcaaD3vp37ZT7bH24ZTs8bVq9wuJINPW2CTs76NtnddenGMSi50Nb_s48bd23iD8bXR5p5nU6yfyg</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Abe, Emiko</creator><creator>Matsubara, Keiichi</creator><creator>Oka, Keizo</creator><creator>Kusanagi, Yasuki</creator><creator>Ito, Masaharu</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia</title><author>Abe, Emiko ; Matsubara, Keiichi ; Oka, Keizo ; Kusanagi, Yasuki ; Ito, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-91519b7a7749bb55e36c7d99fc1f891060f13829e4aebb19b660a3d617f89bca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gene Expression</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intercellular Adhesion Molecule-1 - biosynthesis</topic><topic>Medical sciences</topic><topic>Original Article</topic><topic>Pre-Eclampsia - genetics</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Trophoblasts - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Emiko</creatorcontrib><creatorcontrib>Matsubara, Keiichi</creatorcontrib><creatorcontrib>Oka, Keizo</creatorcontrib><creatorcontrib>Kusanagi, Yasuki</creatorcontrib><creatorcontrib>Ito, Masaharu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic and obstetric investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Emiko</au><au>Matsubara, Keiichi</au><au>Oka, Keizo</au><au>Kusanagi, Yasuki</au><au>Ito, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia</atitle><jtitle>Gynecologic and obstetric investigation</jtitle><addtitle>Gynecol Obstet Invest</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>66</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0378-7346</issn><eissn>1423-002X</eissn><coden>GOBIDS</coden><abstract>In normal pregnancy, trophoblast (TR) invasion plays a crucial role in remodeling the spiral arteries to develop uteroplacental circulation. Disruption of this invasion is associated with deficient uteroplacental circulation, which can lead to the development of preeclampsia (PE) through abnormal expression of adhesion molecules in the placenta and high serum causative factors such as cytokines. We aimed to evaluate whether serum factors in PE influence intercellular adhesion molecule-1 (ICAM-1) expression of TRs. ICAM-1 expression of TRs was measured using flow cytometry and immunohistochemistry was performed to examine the localization of tumor necrosis factor-α (TNFα) and ICAM-1 in placentas derived from women with normal pregnancies and women with PE. Sera from PE patients significantly increased ICAM-1 expression on TRs compared to sera from normal pregnant women; this increase was blocked with an antibody to TNFα. TNFα also enhanced ICAM-1 expression on TRs through nuclear factor-ĸB activation. We conclude that ICAM-1 expressed on TRs is involved in PE pathogenesis and is regulated by cytokines.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18230913</pmid><doi>10.1159/000114253</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-7346 |
| ispartof | Gynecologic and obstetric investigation, 2008-01, Vol.66 (1), p.27-33 |
| issn | 0378-7346 1423-002X |
| language | eng |
| recordid | cdi_crossref_primary_10_1159_000114253 |
| source | Karger Journals; MEDLINE |
| subjects | Adult Biological and medical sciences Diseases of mother, fetus and pregnancy Female Flow Cytometry Gene Expression Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Intercellular Adhesion Molecule-1 - biosynthesis Medical sciences Original Article Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pregnancy Pregnancy. Fetus. Placenta Trophoblasts - metabolism Tumor Necrosis Factor-alpha - metabolism |
| title | Cytokine Regulation of Intercellular Adhesion Molecule-1 Expression on Trophoblasts in Preeclampsia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T10%3A32%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytokine%20Regulation%20of%20Intercellular%20Adhesion%20Molecule-1%20Expression%20on%20Trophoblasts%20in%20Preeclampsia&rft.jtitle=Gynecologic%20and%20obstetric%20investigation&rft.au=Abe,%20Emiko&rft.date=2008-01-01&rft.volume=66&rft.issue=1&rft.spage=27&rft.epage=33&rft.pages=27-33&rft.issn=0378-7346&rft.eissn=1423-002X&rft.coden=GOBIDS&rft_id=info:doi/10.1159/000114253&rft_dat=%3Cproquest_cross%3E1512980311%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223761007&rft_id=info:pmid/18230913&rfr_iscdi=true |