PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection
Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologicall...
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| Veröffentlicht in: | Oncology 2007-01, Vol.72 (Suppl 1), p.52-57 |
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| creator | Kim, Do Young Paik, Yong Han Ahn, Sang Hoon Youn, Young Jun Choi, Jong Won Kim, Ja Kyung Lee, Kwan Sik Chon, Chae Yoon Han, Kwang Hyub |
| description | Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence. |
| doi_str_mv | 10.1159/000111707 |
| format | Article |
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Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.</description><identifier>ISSN: 0030-2414</identifier><identifier>ISBN: 380558413X</identifier><identifier>ISBN: 9783805584135</identifier><identifier>EISSN: 1423-0232</identifier><identifier>EISBN: 3805584148</identifier><identifier>EISBN: 9783805584142</identifier><identifier>DOI: 10.1159/000111707</identifier><identifier>PMID: 18087182</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; alpha-Fetoproteins - metabolism ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers, Tumor - blood ; Cancer ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - surgery ; Early Diagnosis ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatectomy ; Humans ; Liver cancer ; Liver Neoplasms - blood ; Liver Neoplasms - diagnosis ; Liver Neoplasms - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical diagnosis ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - diagnosis ; Postoperative period ; Predictive Value of Tests ; Protein Precursors - blood ; Prothrombin ; ROC Curve ; Sensitivity and Specificity ; Tumors ; Vitamins</subject><ispartof>Oncology, 2007-01, Vol.72 (Suppl 1), p.52-57</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2007 S. Karger AG, Basel.</rights><rights>Copyright (c) 2007 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-3c5eb62a3a47685771b363fe4ef97946f0d1e63cd8edac55847d357fc9d5557e3</citedby><cites>FETCH-LOGICAL-c427t-3c5eb62a3a47685771b363fe4ef97946f0d1e63cd8edac55847d357fc9d5557e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,2423,23911,23912,25121,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19961719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18087182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Do Young</creatorcontrib><creatorcontrib>Paik, Yong Han</creatorcontrib><creatorcontrib>Ahn, Sang Hoon</creatorcontrib><creatorcontrib>Youn, Young Jun</creatorcontrib><creatorcontrib>Choi, Jong Won</creatorcontrib><creatorcontrib>Kim, Ja Kyung</creatorcontrib><creatorcontrib>Lee, Kwan Sik</creatorcontrib><creatorcontrib>Chon, Chae Yoon</creatorcontrib><creatorcontrib>Han, Kwang Hyub</creatorcontrib><title>PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.</description><subject>Adult</subject><subject>Aged</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers, Tumor - blood</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Postoperative period</subject><subject>Predictive Value of Tests</subject><subject>Protein Precursors - blood</subject><subject>Prothrombin</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><subject>Vitamins</subject><issn>0030-2414</issn><issn>1423-0232</issn><isbn>380558413X</isbn><isbn>9783805584135</isbn><isbn>3805584148</isbn><isbn>9783805584142</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0ctrVDEUB-D4wk5HF-6lhEIFF1fzfizLYNuLLRVtxd0lk3tSbnsfY3Kz8L83wwwOuEogX05Ofgehd5R8olTaz4QQSqkm-hk65oZIaQQV5jlaUMF4RRhnLw4H_NdLtCCEk4oVdYSOU3osBbQU6jU6ooYYTQ1bIPet_vn1vKprXCfs8H2CkHt8l4cp4hsXnyDiULbfwecYYZzxFWzcPHno-9y7iFcu-m6cBoddmAv-keND511fbiTwczeNb9Cr4PoEb_frEt1ffLlbXVXXt5f16vy68oLpueJewloxx53Qykit6ZorHkBAsNoKFUhLQXHfGmid3_5Rt1zq4G0rpdTAl-jDru4mTr8zpLkZurTt040w5dQoS7RQ0hR4-h98nHIcS28NYyUXYUt8S_Rxh3ycUooQmk3sBhf_NJQ023E0_8ZR7Mm-YF4P0B7kPuUCzvbApZJNiG70XTo4axXV1Bb3fueeXHyAeAC7d_4CxsCUpg</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Kim, Do Young</creator><creator>Paik, Yong Han</creator><creator>Ahn, Sang Hoon</creator><creator>Youn, Young Jun</creator><creator>Choi, Jong Won</creator><creator>Kim, Ja Kyung</creator><creator>Lee, Kwan Sik</creator><creator>Chon, Chae Yoon</creator><creator>Han, Kwang Hyub</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection</title><author>Kim, Do Young ; Paik, Yong Han ; Ahn, Sang Hoon ; Youn, Young Jun ; Choi, Jong Won ; Kim, Ja Kyung ; Lee, Kwan Sik ; Chon, Chae Yoon ; Han, Kwang Hyub</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-3c5eb62a3a47685771b363fe4ef97946f0d1e63cd8edac55847d357fc9d5557e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Postoperative period</topic><topic>Predictive Value of Tests</topic><topic>Protein Precursors - blood</topic><topic>Prothrombin</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Do Young</creatorcontrib><creatorcontrib>Paik, Yong Han</creatorcontrib><creatorcontrib>Ahn, Sang Hoon</creatorcontrib><creatorcontrib>Youn, Young Jun</creatorcontrib><creatorcontrib>Choi, Jong Won</creatorcontrib><creatorcontrib>Kim, Ja Kyung</creatorcontrib><creatorcontrib>Lee, Kwan Sik</creatorcontrib><creatorcontrib>Chon, Chae Yoon</creatorcontrib><creatorcontrib>Han, Kwang Hyub</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Do Young</au><au>Paik, Yong Han</au><au>Ahn, Sang Hoon</au><au>Youn, Young Jun</au><au>Choi, Jong Won</au><au>Kim, Ja Kyung</au><au>Lee, Kwan Sik</au><au>Chon, Chae Yoon</au><au>Han, Kwang Hyub</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>72</volume><issue>Suppl 1</issue><spage>52</spage><epage>57</epage><pages>52-57</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><isbn>380558413X</isbn><isbn>9783805584135</isbn><eisbn>3805584148</eisbn><eisbn>9783805584142</eisbn><abstract>Objectives: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection. Methods: From April 2001 to March 2004, a total of 245 patients with histologically proven HCC and 267 non-HCC patients were recruited. Serial follow-up measurements of both alpha-fetoprotein (AFP) and PIVKA-II were performed in 27 patients who had recurrent HCC after resection. Results: In the initial HCC diagnosis, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively, at the cutoff of 20 ng/ml for AFP and 40 mAU/ml for PIVKA-II (p < 0.01). The specificity was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. In 27 patients developing recurrent HCC after curative surgical resection, the sensitivity of AFP and PIVKA-II was 40.7% (11/27) and 74.1% (20/27), respectively. Several fluctuating patterns of AFP and PIVKA-II were observed from initial diagnosis to recurrence. Conclusion: Our data suggest that PIVKA-II is a useful tumor marker for HCC, complementary to AFP. Serial measurements of both markers after resection might be helpful for early diagnosis of tumor recurrence.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18087182</pmid><doi>10.1159/000111707</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged alpha-Fetoproteins - metabolism Biological and medical sciences Biomarkers - blood Biomarkers, Tumor - blood Cancer Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - surgery Early Diagnosis Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Hepatectomy Humans Liver cancer Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical diagnosis Medical sciences Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - diagnosis Postoperative period Predictive Value of Tests Protein Precursors - blood Prothrombin ROC Curve Sensitivity and Specificity Tumors Vitamins |
| title | PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection |
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