Biosynthesis of Gastrokine-2 in the Human Gastric Mucosa: Restricted Spatial Expression along the Antral Gland Axis and Differential Interaction with TFF1, TFF2 and Mucins

Gastrokine-2 (GKN2) is a secretory peptide of human gastric surface mucous cells (SMCs). It forms disulfide-linked heterodimers with the trefoil factor family (TFF) peptide TFF1. Binding with TFF2 was also reported. Antral SMCs differ from those of the corpus by their TFF3 expression. The aim of thi...

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Veröffentlicht in:	Cellular physiology and biochemistry 2007-01, Vol.20 (6), p.899-908
Hauptverfasser:	Kouznetsova, Irina, Laubinger, Werner, Kalbacher, Hubert, Kalinski, Thomas, Meyer, Frank, Roessner, Albert, Hoffmann, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - metabolism Chromatography, Gel Duodenum - metabolism Duodenum - pathology Esophagus - metabolism Esophagus - pathology Gastric Juice - metabolism Gastric Mucosa - metabolism Gastric Mucosa - pathology Gene Expression Regulation Humans Lasers Microdissection Mucins - genetics Mucins - metabolism Original Paper Peptides - genetics Peptides - metabolism Protein Binding Pyloric Antrum - metabolism Reverse Transcriptase Polymerase Chain Reaction Tissue Extracts Trefoil Factor-1 Trefoil Factor-2 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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