Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea
Objectives: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. Methods: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) an...
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| Veröffentlicht in: | Intervirology 2007-01, Vol.50 (1), p.52-57 |
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| creator | Kim, Hong Jee, Young Mee Song, Byung-Cheol Shin, Jung Woo Yang, Soo Hyun Mun, Ho-Suk Kim, Hyun-Ju Oh, Eun-Ju Yoon, Jung-Hwan Kim, Yoon-Jun Lee, Hyo-Suk Hwang, Eung-Soo Cha, Chang-Yong Kook, Yoon-Hoh Kim, Bum-Joon |
| description | Objectives: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. Methods: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). Results: Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the adr, adw and ayr serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. Conclusions: The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist. |
| doi_str_mv | 10.1159/000096313 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000096313</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19740770</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-4a0c2a3ebbb2cb0fa23eb61f2fb4ea8c94ea9353e060b3ea0e7ef85d0e8e14973</originalsourceid><addsrcrecordid>eNqF0c1P2zAYBnALbYIOOOw8abJ2mOgh43XsxMlxVEARTCABvUaO-6Y1S-1gJ0L973HVqpN2wQd_SL_nlayHkK8MfjGWlecQV5lzxg_IiImUJ8AAPpERcIAky9L8iHwJ4SWqaOCQHDHJcpFlxYis_7gW9dAqTy87M8eVca1brKlr6BQ71ZveBHpBZ8YPgZ5NL2Zjeo3W9esOA1V2Th_R717G0ocYQNsH-mb6JZ0svbNG05iiN7ZB3RtnN-zWeVQn5HOj2oCnu_OYPF9dPk2myd399c3k912iec76RCjQqeJY13Wqa2hUGu85a9KmFqgKXca95BlHyKHmqAAlNkU2ByyQiVLyY_JzO7fz7nXA0FcrEzS2rbLohlDlBZeSQ_4hZKUUICVE-OM_-OIGb-MnqhQEE5mUIqLxFmnvQvDYVJ03K-XXFYNq01q1by3a77uBQ73C-T-5qymCb1vwV_kF-j3Yxt8B2LWaNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204145774</pqid></control><display><type>article</type><title>Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea</title><source>Karger Journals</source><source>MEDLINE</source><creator>Kim, Hong ; Jee, Young Mee ; Song, Byung-Cheol ; Shin, Jung Woo ; Yang, Soo Hyun ; Mun, Ho-Suk ; Kim, Hyun-Ju ; Oh, Eun-Ju ; Yoon, Jung-Hwan ; Kim, Yoon-Jun ; Lee, Hyo-Suk ; Hwang, Eung-Soo ; Cha, Chang-Yong ; Kook, Yoon-Hoh ; Kim, Bum-Joon</creator><creatorcontrib>Kim, Hong ; Jee, Young Mee ; Song, Byung-Cheol ; Shin, Jung Woo ; Yang, Soo Hyun ; Mun, Ho-Suk ; Kim, Hyun-Ju ; Oh, Eun-Ju ; Yoon, Jung-Hwan ; Kim, Yoon-Jun ; Lee, Hyo-Suk ; Hwang, Eung-Soo ; Cha, Chang-Yong ; Kook, Yoon-Hoh ; Kim, Bum-Joon</creatorcontrib><description>Objectives: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. Methods: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). Results: Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the adr, adw and ayr serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. Conclusions: The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist.</description><identifier>ISSN: 0300-5526</identifier><identifier>EISSN: 1423-0100</identifier><identifier>DOI: 10.1159/000096313</identifier><identifier>PMID: 17164558</identifier><identifier>CODEN: IVRYAK</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Female ; Genotype ; Hepatitis B virus ; Hepatitis B virus - classification ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - virology ; Humans ; Korea - epidemiology ; Male ; Middle Aged ; Molecular Epidemiology ; Original Paper ; Phylogeny ; Sequence Analysis, DNA ; Serotyping</subject><ispartof>Intervirology, 2007-01, Vol.50 (1), p.52-57</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>Copyright 2007 S. Karger AG, Basel.</rights><rights>Copyright S. Karger AG Dec 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-4a0c2a3ebbb2cb0fa23eb61f2fb4ea8c94ea9353e060b3ea0e7ef85d0e8e14973</citedby><cites>FETCH-LOGICAL-c361t-4a0c2a3ebbb2cb0fa23eb61f2fb4ea8c94ea9353e060b3ea0e7ef85d0e8e14973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17164558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hong</creatorcontrib><creatorcontrib>Jee, Young Mee</creatorcontrib><creatorcontrib>Song, Byung-Cheol</creatorcontrib><creatorcontrib>Shin, Jung Woo</creatorcontrib><creatorcontrib>Yang, Soo Hyun</creatorcontrib><creatorcontrib>Mun, Ho-Suk</creatorcontrib><creatorcontrib>Kim, Hyun-Ju</creatorcontrib><creatorcontrib>Oh, Eun-Ju</creatorcontrib><creatorcontrib>Yoon, Jung-Hwan</creatorcontrib><creatorcontrib>Kim, Yoon-Jun</creatorcontrib><creatorcontrib>Lee, Hyo-Suk</creatorcontrib><creatorcontrib>Hwang, Eung-Soo</creatorcontrib><creatorcontrib>Cha, Chang-Yong</creatorcontrib><creatorcontrib>Kook, Yoon-Hoh</creatorcontrib><creatorcontrib>Kim, Bum-Joon</creatorcontrib><title>Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea</title><title>Intervirology</title><addtitle>Intervirology</addtitle><description>Objectives: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. Methods: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). Results: Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the adr, adw and ayr serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. Conclusions: The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - classification</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Korea - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Original Paper</subject><subject>Phylogeny</subject><subject>Sequence Analysis, DNA</subject><subject>Serotyping</subject><issn>0300-5526</issn><issn>1423-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c1P2zAYBnALbYIOOOw8abJ2mOgh43XsxMlxVEARTCABvUaO-6Y1S-1gJ0L973HVqpN2wQd_SL_nlayHkK8MfjGWlecQV5lzxg_IiImUJ8AAPpERcIAky9L8iHwJ4SWqaOCQHDHJcpFlxYis_7gW9dAqTy87M8eVca1brKlr6BQ71ZveBHpBZ8YPgZ5NL2Zjeo3W9esOA1V2Th_R717G0ocYQNsH-mb6JZ0svbNG05iiN7ZB3RtnN-zWeVQn5HOj2oCnu_OYPF9dPk2myd399c3k912iec76RCjQqeJY13Wqa2hUGu85a9KmFqgKXca95BlHyKHmqAAlNkU2ByyQiVLyY_JzO7fz7nXA0FcrEzS2rbLohlDlBZeSQ_4hZKUUICVE-OM_-OIGb-MnqhQEE5mUIqLxFmnvQvDYVJ03K-XXFYNq01q1by3a77uBQ73C-T-5qymCb1vwV_kF-j3Yxt8B2LWaNA</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Kim, Hong</creator><creator>Jee, Young Mee</creator><creator>Song, Byung-Cheol</creator><creator>Shin, Jung Woo</creator><creator>Yang, Soo Hyun</creator><creator>Mun, Ho-Suk</creator><creator>Kim, Hyun-Ju</creator><creator>Oh, Eun-Ju</creator><creator>Yoon, Jung-Hwan</creator><creator>Kim, Yoon-Jun</creator><creator>Lee, Hyo-Suk</creator><creator>Hwang, Eung-Soo</creator><creator>Cha, Chang-Yong</creator><creator>Kook, Yoon-Hoh</creator><creator>Kim, Bum-Joon</creator><general>S. 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classification</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Korea - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Original Paper</topic><topic>Phylogeny</topic><topic>Sequence Analysis, DNA</topic><topic>Serotyping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hong</creatorcontrib><creatorcontrib>Jee, Young Mee</creatorcontrib><creatorcontrib>Song, Byung-Cheol</creatorcontrib><creatorcontrib>Shin, Jung Woo</creatorcontrib><creatorcontrib>Yang, Soo Hyun</creatorcontrib><creatorcontrib>Mun, Ho-Suk</creatorcontrib><creatorcontrib>Kim, Hyun-Ju</creatorcontrib><creatorcontrib>Oh, Eun-Ju</creatorcontrib><creatorcontrib>Yoon, Jung-Hwan</creatorcontrib><creatorcontrib>Kim, Yoon-Jun</creatorcontrib><creatorcontrib>Lee, Hyo-Suk</creatorcontrib><creatorcontrib>Hwang, Eung-Soo</creatorcontrib><creatorcontrib>Cha, Chang-Yong</creatorcontrib><creatorcontrib>Kook, Yoon-Hoh</creatorcontrib><creatorcontrib>Kim, Bum-Joon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Intervirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hong</au><au>Jee, Young Mee</au><au>Song, Byung-Cheol</au><au>Shin, Jung Woo</au><au>Yang, Soo Hyun</au><au>Mun, Ho-Suk</au><au>Kim, Hyun-Ju</au><au>Oh, Eun-Ju</au><au>Yoon, Jung-Hwan</au><au>Kim, Yoon-Jun</au><au>Lee, Hyo-Suk</au><au>Hwang, Eung-Soo</au><au>Cha, Chang-Yong</au><au>Kook, Yoon-Hoh</au><au>Kim, Bum-Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea</atitle><jtitle>Intervirology</jtitle><addtitle>Intervirology</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>50</volume><issue>1</issue><spage>52</spage><epage>57</epage><pages>52-57</pages><issn>0300-5526</issn><eissn>1423-0100</eissn><coden>IVRYAK</coden><abstract>Objectives: Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. Methods: In the present study, we genotyped and serotyped HBV strains from 209 patients in two Korean regions, Seoul (107 patients) and Jeju (102 patients), an island off the southeastern Korean coast. Analyses were conducted using the direct sequencing method targeting the partial surface (S) gene (541 bp). Results: Phylogenetic analysis showed that all HBV strains from the 209 patients belonged to genotype C2 (100%). Of the 209 patients, 193 (92.3%), 12 (5.7%) and 1 (0.5%) were found to have the adr, adw and ayr serotypes, respectively. The other three strains (1.5%) showed unique serotype and were not typeable by sequence analysis. No HBV strains characteristic of Jeju island were observed. Conclusions: The extraordinary predominance of genotype C2 in chronic Korean patients, which is known to be associated with more severe liver disease than genotype B, suggests that the clinical manifestations of Korean HBV chronic patients are likely to differ from those found in other Asian countries, especially in Japan and Taiwan, where genotypes B and C coexist.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17164558</pmid><doi>10.1159/000096313</doi><tpages>6</tpages></addata></record> |
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| ispartof | Intervirology, 2007-01, Vol.50 (1), p.52-57 |
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| source | Karger Journals; MEDLINE |
| subjects | Adult Aged Female Genotype Hepatitis B virus Hepatitis B virus - classification Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - virology Humans Korea - epidemiology Male Middle Aged Molecular Epidemiology Original Paper Phylogeny Sequence Analysis, DNA Serotyping |
| title | Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea |
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