Further Investigation of the Tolerance and Mechanical Adjustability of the Acri.Tec AR-1 PC/IOL in Rabbit Eyes: An Intraocular Lens with Reversibly Adjustable Optical Power
Purpose: To examine the tolerance and mechanical function of an adjustable intraocular lens (IOL) in rabbit eyes. Methods: Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5...
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| Veröffentlicht in: | Ophthalmic research 2006, Vol.38 (5), p.309-312 |
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| creator | Jahn, Claus E. Fromberg, Ingeborg Fesser, Nicole Allgoewer, Ingrid Jahn, Christoph H. Wakili, Nina S. Hofmann-Rummelt, Carmen R. Holbach, Leonard M. Kamppeter, Bernd A. |
| description | Purpose: To examine the tolerance and mechanical function of an adjustable intraocular lens (IOL) in rabbit eyes. Methods: Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5 months. Histopathologic examination of the eyes. Results: Implantation and mechanical adjustment of the PC/IOL were possible. Eyes healed normally. No difference between eyes containing the *Acri.Tec AR-1 PC/IOL and eyes containing the control PC/IOL could be detected with respect to signs of inflammatory reaction, corneal transparency, intraocular pressure and histopathologic appearance. Histopathologic examination of the eyes showed that the *Acri.Tec AR-1 PC/IOL did not cause any damage in rabbit eyes. Conclusion: The *Acri.Tec AR-1 PC/IOL is well tolerated in rabbit eyes for extended periods of time, suggesting that this PC/IOL should be well tolerated in the long run. Surgical adjustment of the adjusting element can be performed with little effort several weeks after implantation. |
| doi_str_mv | 10.1159/000095775 |
| format | Article |
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Methods: Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5 months. Histopathologic examination of the eyes. Results: Implantation and mechanical adjustment of the PC/IOL were possible. Eyes healed normally. No difference between eyes containing the *Acri.Tec AR-1 PC/IOL and eyes containing the control PC/IOL could be detected with respect to signs of inflammatory reaction, corneal transparency, intraocular pressure and histopathologic appearance. Histopathologic examination of the eyes showed that the *Acri.Tec AR-1 PC/IOL did not cause any damage in rabbit eyes. Conclusion: The *Acri.Tec AR-1 PC/IOL is well tolerated in rabbit eyes for extended periods of time, suggesting that this PC/IOL should be well tolerated in the long run. Surgical adjustment of the adjusting element can be performed with little effort several weeks after implantation.</description><identifier>ISSN: 0030-3747</identifier><identifier>EISSN: 1423-0259</identifier><identifier>DOI: 10.1159/000095775</identifier><identifier>PMID: 16974133</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Biocompatible Materials ; Immune Tolerance ; Lens Implantation, Intraocular ; Lens, Crystalline - surgery ; Lenses, Intraocular ; Optics and Photonics ; Original Paper ; Polymethyl Methacrylate ; Prosthesis Design ; Prosthesis Fitting ; Rabbits</subject><ispartof>Ophthalmic research, 2006, Vol.38 (5), p.309-312</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>Copyright (c) 2006 S. Karger AG, Basel.</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2805-423cf243b386567270010e09dac8ae53b52c14f47964505c857c13f4633e79d13</citedby><cites>FETCH-LOGICAL-c2805-423cf243b386567270010e09dac8ae53b52c14f47964505c857c13f4633e79d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16974133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jahn, Claus E.</creatorcontrib><creatorcontrib>Fromberg, Ingeborg</creatorcontrib><creatorcontrib>Fesser, Nicole</creatorcontrib><creatorcontrib>Allgoewer, Ingrid</creatorcontrib><creatorcontrib>Jahn, Christoph H.</creatorcontrib><creatorcontrib>Wakili, Nina S.</creatorcontrib><creatorcontrib>Hofmann-Rummelt, Carmen R.</creatorcontrib><creatorcontrib>Holbach, Leonard M.</creatorcontrib><creatorcontrib>Kamppeter, Bernd A.</creatorcontrib><title>Further Investigation of the Tolerance and Mechanical Adjustability of the Acri.Tec AR-1 PC/IOL in Rabbit Eyes: An Intraocular Lens with Reversibly Adjustable Optical Power</title><title>Ophthalmic research</title><addtitle>Ophthalmic Res</addtitle><description>Purpose: To examine the tolerance and mechanical function of an adjustable intraocular lens (IOL) in rabbit eyes. Methods: Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5 months. Histopathologic examination of the eyes. Results: Implantation and mechanical adjustment of the PC/IOL were possible. Eyes healed normally. No difference between eyes containing the *Acri.Tec AR-1 PC/IOL and eyes containing the control PC/IOL could be detected with respect to signs of inflammatory reaction, corneal transparency, intraocular pressure and histopathologic appearance. Histopathologic examination of the eyes showed that the *Acri.Tec AR-1 PC/IOL did not cause any damage in rabbit eyes. Conclusion: The *Acri.Tec AR-1 PC/IOL is well tolerated in rabbit eyes for extended periods of time, suggesting that this PC/IOL should be well tolerated in the long run. Surgical adjustment of the adjusting element can be performed with little effort several weeks after implantation.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Immune Tolerance</subject><subject>Lens Implantation, Intraocular</subject><subject>Lens, Crystalline - surgery</subject><subject>Lenses, Intraocular</subject><subject>Optics and Photonics</subject><subject>Original Paper</subject><subject>Polymethyl Methacrylate</subject><subject>Prosthesis Design</subject><subject>Prosthesis Fitting</subject><subject>Rabbits</subject><issn>0030-3747</issn><issn>1423-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0UFv2yAUB3A0rVqzboedJ01oh0k7uAUDxuxmRW0XKVOqKDtbGD83ZA5OAbfKd9qHHF2yVBoXJPR7D3h_hD5QckmpUFckLSWkFK_QhPKcZSQX6jWaEMJIxiSX5-htCBtCElbkDTqnhZKcMjZBv29GH9fg8cw9Qoj2Xkc7ODx0OJ3i1dCD184A1q7FP8CstbNG97hqN2OIurG9jft_ujLeXq7A4GqZUXw3vZot5tg6vNRNYyO-3kP4hiuXropeD2bstcdzcAE_2bjGS3gEH2zT70_de8CLXfx74d3wBP4dOut0H-D9cb9AP2-uV9Pv2XxxO5tW88zkJRFZmoDpcs4aVhaikLlMHydAVKtNqUGwRuSG8o5LVXBBhCmFNJR1vGAMpGopu0BfDn13fngY01jqrQ0G-l47GMZQF6UiqbhI8PN_cDOM3qW31XnOC6FSLAl9PSDjhxA8dPXO2632-5qS-jm_-pRfsp-ODcdmC-2LPAaWwMcD-KX9PfgTOJT_AcKJnHg</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Jahn, Claus E.</creator><creator>Fromberg, Ingeborg</creator><creator>Fesser, Nicole</creator><creator>Allgoewer, Ingrid</creator><creator>Jahn, Christoph H.</creator><creator>Wakili, Nina S.</creator><creator>Hofmann-Rummelt, Carmen R.</creator><creator>Holbach, Leonard M.</creator><creator>Kamppeter, Bernd A.</creator><general>S. 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Fromberg, Ingeborg ; Fesser, Nicole ; Allgoewer, Ingrid ; Jahn, Christoph H. ; Wakili, Nina S. ; Hofmann-Rummelt, Carmen R. ; Holbach, Leonard M. ; Kamppeter, Bernd A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2805-423cf243b386567270010e09dac8ae53b52c14f47964505c857c13f4633e79d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Immune Tolerance</topic><topic>Lens Implantation, Intraocular</topic><topic>Lens, Crystalline - surgery</topic><topic>Lenses, Intraocular</topic><topic>Optics and Photonics</topic><topic>Original Paper</topic><topic>Polymethyl Methacrylate</topic><topic>Prosthesis Design</topic><topic>Prosthesis Fitting</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jahn, Claus E.</creatorcontrib><creatorcontrib>Fromberg, Ingeborg</creatorcontrib><creatorcontrib>Fesser, Nicole</creatorcontrib><creatorcontrib>Allgoewer, Ingrid</creatorcontrib><creatorcontrib>Jahn, Christoph H.</creatorcontrib><creatorcontrib>Wakili, Nina S.</creatorcontrib><creatorcontrib>Hofmann-Rummelt, Carmen R.</creatorcontrib><creatorcontrib>Holbach, Leonard M.</creatorcontrib><creatorcontrib>Kamppeter, Bernd A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jahn, Claus E.</au><au>Fromberg, Ingeborg</au><au>Fesser, Nicole</au><au>Allgoewer, Ingrid</au><au>Jahn, Christoph H.</au><au>Wakili, Nina S.</au><au>Hofmann-Rummelt, Carmen R.</au><au>Holbach, Leonard M.</au><au>Kamppeter, Bernd A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further Investigation of the Tolerance and Mechanical Adjustability of the Acri.Tec AR-1 PC/IOL in Rabbit Eyes: An Intraocular Lens with Reversibly Adjustable Optical Power</atitle><jtitle>Ophthalmic research</jtitle><addtitle>Ophthalmic Res</addtitle><date>2006</date><risdate>2006</risdate><volume>38</volume><issue>5</issue><spage>309</spage><epage>312</epage><pages>309-312</pages><issn>0030-3747</issn><eissn>1423-0259</eissn><abstract>Purpose: To examine the tolerance and mechanical function of an adjustable intraocular lens (IOL) in rabbit eyes. Methods: Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5 months. Histopathologic examination of the eyes. Results: Implantation and mechanical adjustment of the PC/IOL were possible. Eyes healed normally. No difference between eyes containing the *Acri.Tec AR-1 PC/IOL and eyes containing the control PC/IOL could be detected with respect to signs of inflammatory reaction, corneal transparency, intraocular pressure and histopathologic appearance. Histopathologic examination of the eyes showed that the *Acri.Tec AR-1 PC/IOL did not cause any damage in rabbit eyes. Conclusion: The *Acri.Tec AR-1 PC/IOL is well tolerated in rabbit eyes for extended periods of time, suggesting that this PC/IOL should be well tolerated in the long run. Surgical adjustment of the adjusting element can be performed with little effort several weeks after implantation.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>16974133</pmid><doi>10.1159/000095775</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Ophthalmic research, 2006, Vol.38 (5), p.309-312 |
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| source | Karger Journals; MEDLINE |
| subjects | Animals Biocompatible Materials Immune Tolerance Lens Implantation, Intraocular Lens, Crystalline - surgery Lenses, Intraocular Optics and Photonics Original Paper Polymethyl Methacrylate Prosthesis Design Prosthesis Fitting Rabbits |
| title | Further Investigation of the Tolerance and Mechanical Adjustability of the Acri.Tec AR-1 PC/IOL in Rabbit Eyes: An Intraocular Lens with Reversibly Adjustable Optical Power |
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