Factors Contributing to Clinical Seizure Lateralization in Patients with Mesial Temporal Lobe Epilepsy
Clinical seizure semiology can provide important information on the lateralization of the epileptogenic zone. We investigated factors associated with clinical seizure lateralization in patients with pathologically proven mesial temporal sclerosis. We reviewed 243 seizures of 58 patients. Clinical la...
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| Veröffentlicht in: | European neurology 2005-01, Vol.54 (4), p.191-198 |
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| creator | Kang, Suk-Yun Lee, Sang-Ahm Yim, Soo Bin Lim, Young Min Kang, Joong Koo Lee, Jung Kyo |
| description | Clinical seizure semiology can provide important information on the lateralization of the epileptogenic zone. We investigated factors associated with clinical seizure lateralization in patients with pathologically proven mesial temporal sclerosis. We reviewed 243 seizures of 58 patients. Clinical lateralization was possible in 155 (63.8%) of 243 seizures. Lateralization was correct in 144 (92.9%) of 155 lateralized seizures. Logistic regression analysis showed that age at onset (p = 0.001; odds ra tio = 1.089, 95% confidence interval = 1.035–1.145) and the contralateral propagation pattern of ictal discharges (p = 0.001; odds ratio = 3.544, 95% confidence interval = 1.723–7.289) correlated with clinical seizure lateralization. The patient group with clinically lateralized seizures had a younger age at onset of habitual seizures compared to the clinically nonlateralized group (11.1 ± 6.3 vs. 15.6 ± 8.4 years; p < 0.001). Of seizures without bitemporal asynchrony or switch of lateralization, 70.7% were clinically lateralized compared with only 46.4% of seizures with asynchrony or lateralization switch. The present results suggest that the age of epilepsy onset and the ictal scalp EEG propagation pattern affect clinical seizure lateralization in patients with mesial temporal sclerosis. |
| doi_str_mv | 10.1159/000090708 |
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We investigated factors associated with clinical seizure lateralization in patients with pathologically proven mesial temporal sclerosis. We reviewed 243 seizures of 58 patients. Clinical lateralization was possible in 155 (63.8%) of 243 seizures. Lateralization was correct in 144 (92.9%) of 155 lateralized seizures. Logistic regression analysis showed that age at onset (p = 0.001; odds ra tio = 1.089, 95% confidence interval = 1.035–1.145) and the contralateral propagation pattern of ictal discharges (p = 0.001; odds ratio = 3.544, 95% confidence interval = 1.723–7.289) correlated with clinical seizure lateralization. The patient group with clinically lateralized seizures had a younger age at onset of habitual seizures compared to the clinically nonlateralized group (11.1 ± 6.3 vs. 15.6 ± 8.4 years; p < 0.001). Of seizures without bitemporal asynchrony or switch of lateralization, 70.7% were clinically lateralized compared with only 46.4% of seizures with asynchrony or lateralization switch. The present results suggest that the age of epilepsy onset and the ictal scalp EEG propagation pattern affect clinical seizure lateralization in patients with mesial temporal sclerosis.</description><identifier>ISSN: 0014-3022</identifier><identifier>EISSN: 1421-9913</identifier><identifier>DOI: 10.1159/000090708</identifier><identifier>PMID: 16401891</identifier><identifier>CODEN: EUNEAP</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Age of Onset ; Analysis of Variance ; Biological and medical sciences ; Blinking - physiology ; Confidence Intervals ; Electroencephalography ; Epilepsy, Temporal Lobe - pathology ; Epilepsy, Temporal Lobe - physiopathology ; Female ; Follow-Up Studies ; Functional Laterality ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Logistic Models ; Male ; Medical sciences ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nervous system (semeiology, syndromes) ; Neurology ; Odds Ratio ; Original Paper ; Retrospective Studies ; Risk Factors ; Sclerosis - physiopathology ; Seizures - physiopathology</subject><ispartof>European neurology, 2005-01, Vol.54 (4), p.191-198</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-ed7c656045982e4944716be0b37dea4af1a14e98475a71275dd3cc237d7053ea3</citedby><cites>FETCH-LOGICAL-c391t-ed7c656045982e4944716be0b37dea4af1a14e98475a71275dd3cc237d7053ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17467537$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16401891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Suk-Yun</creatorcontrib><creatorcontrib>Lee, Sang-Ahm</creatorcontrib><creatorcontrib>Yim, Soo Bin</creatorcontrib><creatorcontrib>Lim, Young Min</creatorcontrib><creatorcontrib>Kang, Joong Koo</creatorcontrib><creatorcontrib>Lee, Jung Kyo</creatorcontrib><title>Factors Contributing to Clinical Seizure Lateralization in Patients with Mesial Temporal Lobe Epilepsy</title><title>European neurology</title><addtitle>Eur Neurol</addtitle><description>Clinical seizure semiology can provide important information on the lateralization of the epileptogenic zone. We investigated factors associated with clinical seizure lateralization in patients with pathologically proven mesial temporal sclerosis. We reviewed 243 seizures of 58 patients. Clinical lateralization was possible in 155 (63.8%) of 243 seizures. Lateralization was correct in 144 (92.9%) of 155 lateralized seizures. Logistic regression analysis showed that age at onset (p = 0.001; odds ra tio = 1.089, 95% confidence interval = 1.035–1.145) and the contralateral propagation pattern of ictal discharges (p = 0.001; odds ratio = 3.544, 95% confidence interval = 1.723–7.289) correlated with clinical seizure lateralization. The patient group with clinically lateralized seizures had a younger age at onset of habitual seizures compared to the clinically nonlateralized group (11.1 ± 6.3 vs. 15.6 ± 8.4 years; p < 0.001). Of seizures without bitemporal asynchrony or switch of lateralization, 70.7% were clinically lateralized compared with only 46.4% of seizures with asynchrony or lateralization switch. The present results suggest that the age of epilepsy onset and the ictal scalp EEG propagation pattern affect clinical seizure lateralization in patients with mesial temporal sclerosis.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blinking - physiology</subject><subject>Confidence Intervals</subject><subject>Electroencephalography</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Epilepsy, Temporal Lobe - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Functional Laterality</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sclerosis - physiopathology</subject><subject>Seizures - physiopathology</subject><issn>0014-3022</issn><issn>1421-9913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0UFrFDEUB_Agil1rD54FCUKFHsbmZZLJ5ChLq4UVhbbnIZN5U1Nnk2mSobSf3sguLXgxlyTkx3vk_Ql5B-wzgNSnrCzNFGtfkBUIDpXWUL8kK8ZAVDXj_IC8Sem2XKVW7WtyAI1g0GpYkfHc2Bxiouvgc3T9kp2_oTnQ9eS8s2ail-gel4h0YzJGM7lHk13w1Hn6s5zQ50TvXf5Fv2NyhV_hdg7F0U3okZ7NbsI5Pbwlr0YzJTza74fk-vzsav2t2vz4erH-sqlsrSFXOCjbyIYJqVuOQguhoOmR9bUa0AgzggGBuhVKGgVcyWGoreXlVTFZo6kPyadd3TmGuwVT7rYuWZwm4zEsqVOsDExI_l_Iy0Cl5LrAj__A27BEXz7RgRZacdWKgk52yMaQUsSxm6PbmvjQAev-RtQ9RVTsh33Bpd_i8Cz3mRRwvAcmlQDGaLx16dkp0ShZq-Le79xvE28wPoFdmz8qaqBH</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Kang, Suk-Yun</creator><creator>Lee, Sang-Ahm</creator><creator>Yim, Soo Bin</creator><creator>Lim, Young Min</creator><creator>Kang, Joong Koo</creator><creator>Lee, Jung Kyo</creator><general>Karger</general><general>S. 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Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sclerosis - physiopathology</topic><topic>Seizures - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Suk-Yun</creatorcontrib><creatorcontrib>Lee, Sang-Ahm</creatorcontrib><creatorcontrib>Yim, Soo Bin</creatorcontrib><creatorcontrib>Lim, Young Min</creatorcontrib><creatorcontrib>Kang, Joong Koo</creatorcontrib><creatorcontrib>Lee, Jung Kyo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>European neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Suk-Yun</au><au>Lee, Sang-Ahm</au><au>Yim, Soo Bin</au><au>Lim, Young Min</au><au>Kang, Joong Koo</au><au>Lee, Jung Kyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Contributing to Clinical Seizure Lateralization in Patients with Mesial Temporal Lobe Epilepsy</atitle><jtitle>European neurology</jtitle><addtitle>Eur Neurol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>54</volume><issue>4</issue><spage>191</spage><epage>198</epage><pages>191-198</pages><issn>0014-3022</issn><eissn>1421-9913</eissn><coden>EUNEAP</coden><abstract>Clinical seizure semiology can provide important information on the lateralization of the epileptogenic zone. We investigated factors associated with clinical seizure lateralization in patients with pathologically proven mesial temporal sclerosis. We reviewed 243 seizures of 58 patients. Clinical lateralization was possible in 155 (63.8%) of 243 seizures. Lateralization was correct in 144 (92.9%) of 155 lateralized seizures. Logistic regression analysis showed that age at onset (p = 0.001; odds ra tio = 1.089, 95% confidence interval = 1.035–1.145) and the contralateral propagation pattern of ictal discharges (p = 0.001; odds ratio = 3.544, 95% confidence interval = 1.723–7.289) correlated with clinical seizure lateralization. The patient group with clinically lateralized seizures had a younger age at onset of habitual seizures compared to the clinically nonlateralized group (11.1 ± 6.3 vs. 15.6 ± 8.4 years; p < 0.001). Of seizures without bitemporal asynchrony or switch of lateralization, 70.7% were clinically lateralized compared with only 46.4% of seizures with asynchrony or lateralization switch. The present results suggest that the age of epilepsy onset and the ictal scalp EEG propagation pattern affect clinical seizure lateralization in patients with mesial temporal sclerosis.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16401891</pmid><doi>10.1159/000090708</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Age of Onset Analysis of Variance Biological and medical sciences Blinking - physiology Confidence Intervals Electroencephalography Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology Female Follow-Up Studies Functional Laterality Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Logistic Models Male Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system (semeiology, syndromes) Neurology Odds Ratio Original Paper Retrospective Studies Risk Factors Sclerosis - physiopathology Seizures - physiopathology |
| title | Factors Contributing to Clinical Seizure Lateralization in Patients with Mesial Temporal Lobe Epilepsy |
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