PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships
Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Pr...
Gespeichert in:
| Veröffentlicht in: | Community genetics 2006-01, Vol.9 (1), p.55-61 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | 1 |
| container_start_page | 55 |
| container_title | Community genetics |
| container_volume | 9 |
| creator | Krawczak, Michael Nikolaus, Susanna von Eberstein, Huberta Croucher, Peter J.P. Mokhtari, Nour Eddine El Schreiber, Stefan |
| description | Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition. |
| doi_str_mv | 10.1159/000090694 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000090694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26679502</jstor_id><sourcerecordid>26679502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-c6264e25a01020f96448de7cb2d4b4488f73ceb12822897d31894e43ed2837513</originalsourceid><addsrcrecordid>eNpdkEtLAzEUheO7D124LrpwIbgYvbl5L6VoFQq60HWYR0Zap52adBb-e1Nm2oKBSy6c7x4Oh5BLCveUCvMA8RmQhh-QAWNUA2XA9SHpU46YoGbsKAoahIij5PFWUEb0yCCEOUC0UeKM9KjkBoyEPjl9r1cTtzwnJ2VaBXfR_UPy-fz0MX5Jpm-T1_HjNMk5N-sklyi5Q5ECBYTSSM514VSeYcGzuOtSsdxlFDWiNqqIKQ13nLkixlOCsiG5bX1Xvv5pXFjbxSzkrqrSpaubYBG02gSL4M0_cF43fhmzWURGGTIjI3TXQrmvQ_CutCs_W6T-11Kwm87srrPIXneGTbZwxZ7sqojAqAW-U__l_A7Ynl-16jys672IUsZ6Adkfr6Nu9Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223132396</pqid></control><display><type>article</type><title>PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships</title><source>MEDLINE</source><source>JSTOR</source><source>Karger E-Journals</source><creator>Krawczak, Michael ; Nikolaus, Susanna ; von Eberstein, Huberta ; Croucher, Peter J.P. ; Mokhtari, Nour Eddine El ; Schreiber, Stefan</creator><creatorcontrib>Krawczak, Michael ; Nikolaus, Susanna ; von Eberstein, Huberta ; Croucher, Peter J.P. ; Mokhtari, Nour Eddine El ; Schreiber, Stefan</creatorcontrib><description>Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.</description><identifier>ISSN: 1422-2795</identifier><identifier>ISSN: 1662-4246</identifier><identifier>ISBN: 3805580576</identifier><identifier>ISBN: 9783805580571</identifier><identifier>EISSN: 1422-2833</identifier><identifier>EISSN: 1662-8063</identifier><identifier>EISBN: 3318013048</identifier><identifier>EISBN: 9783318013047</identifier><identifier>DOI: 10.1159/000090694</identifier><identifier>PMID: 16490960</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Assurance ; Cardiovascular Diseases - genetics ; Cross-Sectional Studies ; Environmental diseases ; Environmental Illness - genetics ; Genetic Testing ; Genetics, Population ; Genotype ; Germany ; Humans ; Mental Disorders - genetics ; Nervous System Diseases - genetics ; Patient Selection ; Phenotype ; Prospective Studies ; Research Design</subject><ispartof>Community genetics, 2006-01, Vol.9 (1), p.55-61</ispartof><rights>2006 S. Karger AG</rights><rights>2006 S. Karger AG, Basel</rights><rights>Copyright (c) 2006 S. Karger AG, Basel.</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-c6264e25a01020f96448de7cb2d4b4488f73ceb12822897d31894e43ed2837513</citedby><cites>FETCH-LOGICAL-c449t-c6264e25a01020f96448de7cb2d4b4488f73ceb12822897d31894e43ed2837513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26679502$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26679502$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2423,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16490960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krawczak, Michael</creatorcontrib><creatorcontrib>Nikolaus, Susanna</creatorcontrib><creatorcontrib>von Eberstein, Huberta</creatorcontrib><creatorcontrib>Croucher, Peter J.P.</creatorcontrib><creatorcontrib>Mokhtari, Nour Eddine El</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><title>PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships</title><title>Community genetics</title><addtitle>Public Health Genomics</addtitle><description>Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.</description><subject>Assurance</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Environmental diseases</subject><subject>Environmental Illness - genetics</subject><subject>Genetic Testing</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Germany</subject><subject>Humans</subject><subject>Mental Disorders - genetics</subject><subject>Nervous System Diseases - genetics</subject><subject>Patient Selection</subject><subject>Phenotype</subject><subject>Prospective Studies</subject><subject>Research Design</subject><issn>1422-2795</issn><issn>1662-4246</issn><issn>1422-2833</issn><issn>1662-8063</issn><isbn>3805580576</isbn><isbn>9783805580571</isbn><isbn>3318013048</isbn><isbn>9783318013047</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkEtLAzEUheO7D124LrpwIbgYvbl5L6VoFQq60HWYR0Zap52adBb-e1Nm2oKBSy6c7x4Oh5BLCveUCvMA8RmQhh-QAWNUA2XA9SHpU46YoGbsKAoahIij5PFWUEb0yCCEOUC0UeKM9KjkBoyEPjl9r1cTtzwnJ2VaBXfR_UPy-fz0MX5Jpm-T1_HjNMk5N-sklyi5Q5ECBYTSSM514VSeYcGzuOtSsdxlFDWiNqqIKQ13nLkixlOCsiG5bX1Xvv5pXFjbxSzkrqrSpaubYBG02gSL4M0_cF43fhmzWURGGTIjI3TXQrmvQ_CutCs_W6T-11Kwm87srrPIXneGTbZwxZ7sqojAqAW-U__l_A7Ynl-16jys672IUsZ6Adkfr6Nu9Q</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Krawczak, Michael</creator><creator>Nikolaus, Susanna</creator><creator>von Eberstein, Huberta</creator><creator>Croucher, Peter J.P.</creator><creator>Mokhtari, Nour Eddine El</creator><creator>Schreiber, Stefan</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20060101</creationdate><title>PopGen</title><author>Krawczak, Michael ; Nikolaus, Susanna ; von Eberstein, Huberta ; Croucher, Peter J.P. ; Mokhtari, Nour Eddine El ; Schreiber, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-c6264e25a01020f96448de7cb2d4b4488f73ceb12822897d31894e43ed2837513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Assurance</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Environmental diseases</topic><topic>Environmental Illness - genetics</topic><topic>Genetic Testing</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Germany</topic><topic>Humans</topic><topic>Mental Disorders - genetics</topic><topic>Nervous System Diseases - genetics</topic><topic>Patient Selection</topic><topic>Phenotype</topic><topic>Prospective Studies</topic><topic>Research Design</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krawczak, Michael</creatorcontrib><creatorcontrib>Nikolaus, Susanna</creatorcontrib><creatorcontrib>von Eberstein, Huberta</creatorcontrib><creatorcontrib>Croucher, Peter J.P.</creatorcontrib><creatorcontrib>Mokhtari, Nour Eddine El</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest Medical & Health Databases)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Community genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krawczak, Michael</au><au>Nikolaus, Susanna</au><au>von Eberstein, Huberta</au><au>Croucher, Peter J.P.</au><au>Mokhtari, Nour Eddine El</au><au>Schreiber, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships</atitle><jtitle>Community genetics</jtitle><addtitle>Public Health Genomics</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>9</volume><issue>1</issue><spage>55</spage><epage>61</epage><pages>55-61</pages><issn>1422-2795</issn><issn>1662-4246</issn><eissn>1422-2833</eissn><eissn>1662-8063</eissn><isbn>3805580576</isbn><isbn>9783805580571</isbn><eisbn>3318013048</eisbn><eisbn>9783318013047</eisbn><abstract>Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>16490960</pmid><doi>10.1159/000090694</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-2795 |
| ispartof | Community genetics, 2006-01, Vol.9 (1), p.55-61 |
| issn | 1422-2795 1662-4246 1422-2833 1662-8063 |
| language | eng |
| recordid | cdi_crossref_primary_10_1159_000090694 |
| source | MEDLINE; JSTOR; Karger E-Journals |
| subjects | Assurance Cardiovascular Diseases - genetics Cross-Sectional Studies Environmental diseases Environmental Illness - genetics Genetic Testing Genetics, Population Genotype Germany Humans Mental Disorders - genetics Nervous System Diseases - genetics Patient Selection Phenotype Prospective Studies Research Design |
| title | PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T09%3A48%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PopGen:%20Population-Based%20Recruitment%20of%20Patients%20and%20Controls%20for%20the%20Analysis%20of%20Complex%20Genotype-Phenotype%20Relationships&rft.jtitle=Community%20genetics&rft.au=Krawczak,%20Michael&rft.date=2006-01-01&rft.volume=9&rft.issue=1&rft.spage=55&rft.epage=61&rft.pages=55-61&rft.issn=1422-2795&rft.eissn=1422-2833&rft.isbn=3805580576&rft.isbn_list=9783805580571&rft_id=info:doi/10.1159/000090694&rft_dat=%3Cjstor_cross%3E26679502%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&rft.eisbn=3318013048&rft.eisbn_list=9783318013047&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223132396&rft_id=info:pmid/16490960&rft_jstor_id=26679502&rfr_iscdi=true |