Mechanisms of DNA double strand break repair and chromosome aberration formation

It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes by endogenous processes or exogenous agents can in principle be repaired either by non-homologous endjoining (NHEJ), or h...

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Veröffentlicht in:	Cytogenetic and Genome Research 2004-01, Vol.104 (1-4), p.14-20
Hauptverfasser:	Iliakis, G., Wang, H., Perrault, A.R., Boecker, W., Rosidi, B., Windhofer, F., Wu, W., Guan, J., Terzoudi, G., Pantelias, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Avian Proteins B-Lymphocytes - metabolism B-Lymphocytes - radiation effects Basic Aspects Calcium-Binding Proteins - metabolism Cell Line, Tumor - metabolism Cell Line, Tumor - radiation effects Chickens Chromosome Aberrations DNA - genetics DNA - metabolism DNA - radiation effects DNA Damage DNA Helicases - metabolism DNA Ligase ATP DNA Ligases - metabolism DNA Repair - drug effects DNA Repair - physiology DNA-Activated Protein Kinase DNA-Binding Proteins - metabolism Electrophoresis, Gel, Pulsed-Field Enzyme Inhibitors - pharmacology Eukaryotic Cells - metabolism Eukaryotic Cells - radiation effects Glioblastoma - pathology Humans Kinetics Ku Autoantigen Models, Genetic Nuclear Proteins Protein-Serine-Threonine Kinases - metabolism Rad51 Recombinase Rad52 DNA Repair and Recombination Protein Space life sciences
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