Postural Skin Colour Changes during the Corticosteroid Blanching Assay
Objective: To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. Method: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments....
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| Veröffentlicht in: | Skin pharmacology and applied skin physiology 1999-07, Vol.12 (4), p.199-210 |
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| creator | Henry, F. Fumal, I. Piérard, G.E. |
| description | Objective: To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. Method: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one conducted in 60 normal adults aimed at quantifying the range of variation in the skin chromaticity a* when the arm was successively positioned horizontally and vertically, either in the upward or downward direction. In the second study, 16 volunteers were selected according to a weak spontaneous postural dependency of the limb in a* ( |
| doi_str_mv | 10.1159/000066244 |
| format | Article |
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Method: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one conducted in 60 normal adults aimed at quantifying the range of variation in the skin chromaticity a* when the arm was successively positioned horizontally and vertically, either in the upward or downward direction. In the second study, 16 volunteers were selected according to a weak spontaneous postural dependency of the limb in a* (<2 units). The blanching effect of 0.1% mometasone furoate, 0.1% betamethasone valerate and petrolatum were compared to the colour of an untreated site. Chromaticity a* and the colorimetric variable (ΔtL* 2 + Δta* 2 ) 0.5 were measured in time following a 2-hour application. Results: The postural variations in skin colour varied among subjects. The majority of them (80%) presented a difference in a* higher than 2 units between the upright and downward arm positions. The upright position appeared to be the most sensitive to show significant differences in the VCA. Mometasone furoate exhibited the most prominent effect, significantly higher than betamethasone valerate and controls. Conclusion: The corticosteroid VCA is influenced by the position of the limb. The upright position increases the sensitivity of the test. Mometasone furoate is more potent than betamethasone valerate.</description><identifier>ISSN: 1660-5527</identifier><identifier>ISSN: 1422-2868</identifier><identifier>EISSN: 1660-5535</identifier><identifier>EISSN: 1422-2906</identifier><identifier>DOI: 10.1159/000066244</identifier><identifier>PMID: 10420140</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Administration, Topical ; Adrenal Cortex Hormones - administration & dosage ; Adult ; Anti-Inflammatory Agents - administration & dosage ; Betamethasone - administration & dosage ; Betamethasone - analogs & derivatives ; Biological and medical sciences ; Colorimetry ; Double-Blind Method ; Forearm - blood supply ; Forearm - physiology ; Humans ; Medical sciences ; Mometasone Furoate ; Original Research Article ; Pharmacology. Drug treatments ; Posture - physiology ; Pregnadienediols - administration & dosage ; Regional Blood Flow - drug effects ; Regional Blood Flow - physiology ; Skin - blood supply ; Skin Pigmentation - physiology ; Skin, nail, hair, dermoskeleton ; Vasoconstriction - drug effects ; Vasoconstriction - physiology</subject><ispartof>Skin pharmacology and applied skin physiology, 1999-07, Vol.12 (4), p.199-210</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-dc1227ad3ead60b927a953fc894578d474012326062947701d0106ec149c0f583</citedby><cites>FETCH-LOGICAL-c357t-dc1227ad3ead60b927a953fc894578d474012326062947701d0106ec149c0f583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2003132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10420140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henry, F.</creatorcontrib><creatorcontrib>Fumal, I.</creatorcontrib><creatorcontrib>Piérard, G.E.</creatorcontrib><title>Postural Skin Colour Changes during the Corticosteroid Blanching Assay</title><title>Skin pharmacology and applied skin physiology</title><addtitle>Skin Pharmacol Physiol</addtitle><description>Objective: To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. Method: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one conducted in 60 normal adults aimed at quantifying the range of variation in the skin chromaticity a* when the arm was successively positioned horizontally and vertically, either in the upward or downward direction. In the second study, 16 volunteers were selected according to a weak spontaneous postural dependency of the limb in a* (<2 units). The blanching effect of 0.1% mometasone furoate, 0.1% betamethasone valerate and petrolatum were compared to the colour of an untreated site. Chromaticity a* and the colorimetric variable (ΔtL* 2 + Δta* 2 ) 0.5 were measured in time following a 2-hour application. Results: The postural variations in skin colour varied among subjects. The majority of them (80%) presented a difference in a* higher than 2 units between the upright and downward arm positions. The upright position appeared to be the most sensitive to show significant differences in the VCA. Mometasone furoate exhibited the most prominent effect, significantly higher than betamethasone valerate and controls. Conclusion: The corticosteroid VCA is influenced by the position of the limb. The upright position increases the sensitivity of the test. Mometasone furoate is more potent than betamethasone valerate.</description><subject>Administration, Topical</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Betamethasone - administration & dosage</subject><subject>Betamethasone - analogs & derivatives</subject><subject>Biological and medical sciences</subject><subject>Colorimetry</subject><subject>Double-Blind Method</subject><subject>Forearm - blood supply</subject><subject>Forearm - physiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mometasone Furoate</subject><subject>Original Research Article</subject><subject>Pharmacology. Drug treatments</subject><subject>Posture - physiology</subject><subject>Pregnadienediols - administration & dosage</subject><subject>Regional Blood Flow - drug effects</subject><subject>Regional Blood Flow - physiology</subject><subject>Skin - blood supply</subject><subject>Skin Pigmentation - physiology</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - physiology</subject><issn>1660-5527</issn><issn>1422-2868</issn><issn>1660-5535</issn><issn>1422-2906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0M9LwzAUB_AgipvTg2dBiojgofryeznO4lQYKKjnkqXp1q1rZ9Ie9t-b0VHEXPLgfXh5-SJ0ieEBY64eIRwhCGNHaIiFgJhzyo_7msgBOvN-BUCExOIUDTAwApjBEE0_at-0TpfR57qooqQu69ZFyVJXC-ujrHVFtYiapQ0d1xQmYOvqIoueSl2Z5b458V7vztFJrktvLw73CH1Pn7-S13j2_vKWTGaxoVw2cWYwIVJn1OpMwFyFWnGam7FiXI4zJhlgQokAQRSTEnAGGIQ1mCkDOR_TEbrr5m5d_dNa36Sbwhtbhm1s3fpUKIUpYzLAm39wFT5Whd1SQjhhFHMa0H2HjKu9dzZPt67YaLdLMaT7ZNM-2WCvDwPb-cZmf2QXZQC3B6C90WXuQkCF7x0BoJiSwK46ttZuYV3f7175BUQrhWo</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Henry, F.</creator><creator>Fumal, I.</creator><creator>Piérard, G.E.</creator><general>Karger</general><general>S. 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Drug treatments</topic><topic>Posture - physiology</topic><topic>Pregnadienediols - administration & dosage</topic><topic>Regional Blood Flow - drug effects</topic><topic>Regional Blood Flow - physiology</topic><topic>Skin - blood supply</topic><topic>Skin Pigmentation - physiology</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henry, F.</creatorcontrib><creatorcontrib>Fumal, I.</creatorcontrib><creatorcontrib>Piérard, G.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skin pharmacology and applied skin physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henry, F.</au><au>Fumal, I.</au><au>Piérard, G.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postural Skin Colour Changes during the Corticosteroid Blanching Assay</atitle><jtitle>Skin pharmacology and applied skin physiology</jtitle><addtitle>Skin Pharmacol Physiol</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>12</volume><issue>4</issue><spage>199</spage><epage>210</epage><pages>199-210</pages><issn>1660-5527</issn><issn>1422-2868</issn><eissn>1660-5535</eissn><eissn>1422-2906</eissn><abstract>Objective: To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. Method: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one conducted in 60 normal adults aimed at quantifying the range of variation in the skin chromaticity a* when the arm was successively positioned horizontally and vertically, either in the upward or downward direction. In the second study, 16 volunteers were selected according to a weak spontaneous postural dependency of the limb in a* (<2 units). The blanching effect of 0.1% mometasone furoate, 0.1% betamethasone valerate and petrolatum were compared to the colour of an untreated site. Chromaticity a* and the colorimetric variable (ΔtL* 2 + Δta* 2 ) 0.5 were measured in time following a 2-hour application. Results: The postural variations in skin colour varied among subjects. The majority of them (80%) presented a difference in a* higher than 2 units between the upright and downward arm positions. The upright position appeared to be the most sensitive to show significant differences in the VCA. Mometasone furoate exhibited the most prominent effect, significantly higher than betamethasone valerate and controls. Conclusion: The corticosteroid VCA is influenced by the position of the limb. The upright position increases the sensitivity of the test. Mometasone furoate is more potent than betamethasone valerate.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10420140</pmid><doi>10.1159/000066244</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 1660-5527 |
| ispartof | Skin pharmacology and applied skin physiology, 1999-07, Vol.12 (4), p.199-210 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1159_000066244 |
| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Administration, Topical Adrenal Cortex Hormones - administration & dosage Adult Anti-Inflammatory Agents - administration & dosage Betamethasone - administration & dosage Betamethasone - analogs & derivatives Biological and medical sciences Colorimetry Double-Blind Method Forearm - blood supply Forearm - physiology Humans Medical sciences Mometasone Furoate Original Research Article Pharmacology. Drug treatments Posture - physiology Pregnadienediols - administration & dosage Regional Blood Flow - drug effects Regional Blood Flow - physiology Skin - blood supply Skin Pigmentation - physiology Skin, nail, hair, dermoskeleton Vasoconstriction - drug effects Vasoconstriction - physiology |
| title | Postural Skin Colour Changes during the Corticosteroid Blanching Assay |
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