Treatment of Suprachoroidal Hemorrhage with Tissue Plasminogen Activator
We evaluated the efficacy of tissue plasminogen activator in treating experimental suprachoroidal hemorrhage. Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for...
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| Veröffentlicht in: | Ophthalmologica (Basel) 1998, Vol.212 (2), p.120-125 |
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| container_title | Ophthalmologica (Basel) |
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| creator | Kwon, Oh W. Kang, Shin J. Lee, Jae B. Lee, Sung C. Yoon, Young D. Oh, Jung H. |
| description | We evaluated the efficacy of tissue plasminogen activator in treating experimental suprachoroidal hemorrhage. Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for treatment with a surgical sponge soaked in 25, 50, or 75 μg of tissue plasminogen activator (tPA) or balanced salt solution (BSS®) as a control. The time when initiation and completion of clot dissolution occurred was established, and histological examination was performed to assess damage. Clot dissolution started within 30 min in the 50- and 75-μg tPA group, whereas it took 2.75 days in the control group; complete dissolution of blood clots took 4.5 h in the 75-μg tPA group and 14 days in the control group. Histological examination revealed a minimal change in photoreceptors within 6 h after treatment with 75 μg tPA. Treatment of suprachoroidal hemorrhage with tPA seems to be effective, but further investigations for determining the effective and nontoxic dose are required. |
| doi_str_mv | 10.1159/000027295 |
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Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for treatment with a surgical sponge soaked in 25, 50, or 75 μg of tissue plasminogen activator (tPA) or balanced salt solution (BSS®) as a control. The time when initiation and completion of clot dissolution occurred was established, and histological examination was performed to assess damage. Clot dissolution started within 30 min in the 50- and 75-μg tPA group, whereas it took 2.75 days in the control group; complete dissolution of blood clots took 4.5 h in the 75-μg tPA group and 14 days in the control group. Histological examination revealed a minimal change in photoreceptors within 6 h after treatment with 75 μg tPA. Treatment of suprachoroidal hemorrhage with tPA seems to be effective, but further investigations for determining the effective and nontoxic dose are required.</description><identifier>ISSN: 0030-3755</identifier><identifier>EISSN: 1423-0267</identifier><identifier>DOI: 10.1159/000027295</identifier><identifier>PMID: 9486552</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Administration, Topical ; Animals ; Biological and medical sciences ; Choroid Hemorrhage - blood ; Choroid Hemorrhage - drug therapy ; Choroid Hemorrhage - pathology ; Dose-Response Relationship, Drug ; Eye ; Follow-Up Studies ; Medical sciences ; Original Paper · Travail original · Originalarbeit ; Pharmacology. Drug treatments ; Photoreceptor Cells - drug effects ; Photoreceptor Cells - pathology ; Plasminogen Activators - therapeutic use ; Rabbits ; Random Allocation ; Surgical Sponges ; Thrombolytic Therapy ; Tissue Plasminogen Activator - therapeutic use ; Treatment Outcome</subject><ispartof>Ophthalmologica (Basel), 1998, Vol.212 (2), p.120-125</ispartof><rights>1998 S. Karger AG, Basel</rights><rights>1998 INIST-CNRS</rights><rights>Copyright (c) 1998 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-1a0974a77239e9443f0dd4db1ecd5a5098bbe4513776f695c0987814a01571c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2428,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2116893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9486552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Oh W.</creatorcontrib><creatorcontrib>Kang, Shin J.</creatorcontrib><creatorcontrib>Lee, Jae B.</creatorcontrib><creatorcontrib>Lee, Sung C.</creatorcontrib><creatorcontrib>Yoon, Young D.</creatorcontrib><creatorcontrib>Oh, Jung H.</creatorcontrib><title>Treatment of Suprachoroidal Hemorrhage with Tissue Plasminogen Activator</title><title>Ophthalmologica (Basel)</title><addtitle>Ophthalmologica</addtitle><description>We evaluated the efficacy of tissue plasminogen activator in treating experimental suprachoroidal hemorrhage. Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for treatment with a surgical sponge soaked in 25, 50, or 75 μg of tissue plasminogen activator (tPA) or balanced salt solution (BSS®) as a control. The time when initiation and completion of clot dissolution occurred was established, and histological examination was performed to assess damage. Clot dissolution started within 30 min in the 50- and 75-μg tPA group, whereas it took 2.75 days in the control group; complete dissolution of blood clots took 4.5 h in the 75-μg tPA group and 14 days in the control group. Histological examination revealed a minimal change in photoreceptors within 6 h after treatment with 75 μg tPA. Treatment of suprachoroidal hemorrhage with tPA seems to be effective, but further investigations for determining the effective and nontoxic dose are required.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choroid Hemorrhage - blood</subject><subject>Choroid Hemorrhage - drug therapy</subject><subject>Choroid Hemorrhage - pathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eye</subject><subject>Follow-Up Studies</subject><subject>Medical sciences</subject><subject>Original Paper · Travail original · Originalarbeit</subject><subject>Pharmacology. Drug treatments</subject><subject>Photoreceptor Cells - drug effects</subject><subject>Photoreceptor Cells - pathology</subject><subject>Plasminogen Activators - therapeutic use</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Surgical Sponges</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0030-3755</issn><issn>1423-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0M1LwzAYBvAgypzTg2cRyhDBQzWfTXMcok4QFJzn8i5Nt862mUmr-N8bXZkg5hLI8-PNy4PQMcGXhAh1hcOhkiqxg4aEUxZjmshdNMSY4ZhJIfbRgfcrjANWZIAGiqeJEHSIpjNnoK1N00a2iJ67tQO9tM6WOVTR1NTWuSUsTPRRtstoVnrfmeipAl-XjV2YJprotnyH1rpDtFdA5c1Rf4_Qy-3N7HoaPzze3V9PHmLNUtbGBLCSHKSkTBnFOStwnvN8TozOBQis0vnccEGYlEmRKKHDi0wJh7C6JJqzETrfzF07-9YZ32Z16bWpKmiM7XwmlcQ8pSTA8R-4sp1rwm4ZpVxiwUJRI3SxQdpZ750psrUra3CfGcHZd7XZttpgT_uB3bw2-Vb2XYb8rM_Ba6gKB40u_ZZRQpJUscBONuwV3MK437z_ZPxv-vg0_QHZOi_YF2rWks4</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Kwon, Oh W.</creator><creator>Kang, Shin J.</creator><creator>Lee, Jae B.</creator><creator>Lee, Sung C.</creator><creator>Yoon, Young D.</creator><creator>Oh, Jung H.</creator><general>Karger</general><general>S. 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Drug treatments</topic><topic>Photoreceptor Cells - drug effects</topic><topic>Photoreceptor Cells - pathology</topic><topic>Plasminogen Activators - therapeutic use</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Surgical Sponges</topic><topic>Thrombolytic Therapy</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Oh W.</creatorcontrib><creatorcontrib>Kang, Shin J.</creatorcontrib><creatorcontrib>Lee, Jae B.</creatorcontrib><creatorcontrib>Lee, Sung C.</creatorcontrib><creatorcontrib>Yoon, Young D.</creatorcontrib><creatorcontrib>Oh, Jung H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmologica (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Oh W.</au><au>Kang, Shin J.</au><au>Lee, Jae B.</au><au>Lee, Sung C.</au><au>Yoon, Young D.</au><au>Oh, Jung H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Suprachoroidal Hemorrhage with Tissue Plasminogen Activator</atitle><jtitle>Ophthalmologica (Basel)</jtitle><addtitle>Ophthalmologica</addtitle><date>1998</date><risdate>1998</risdate><volume>212</volume><issue>2</issue><spage>120</spage><epage>125</epage><pages>120-125</pages><issn>0030-3755</issn><eissn>1423-0267</eissn><abstract>We evaluated the efficacy of tissue plasminogen activator in treating experimental suprachoroidal hemorrhage. Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for treatment with a surgical sponge soaked in 25, 50, or 75 μg of tissue plasminogen activator (tPA) or balanced salt solution (BSS®) as a control. The time when initiation and completion of clot dissolution occurred was established, and histological examination was performed to assess damage. Clot dissolution started within 30 min in the 50- and 75-μg tPA group, whereas it took 2.75 days in the control group; complete dissolution of blood clots took 4.5 h in the 75-μg tPA group and 14 days in the control group. Histological examination revealed a minimal change in photoreceptors within 6 h after treatment with 75 μg tPA. Treatment of suprachoroidal hemorrhage with tPA seems to be effective, but further investigations for determining the effective and nontoxic dose are required.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9486552</pmid><doi>10.1159/000027295</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Topical Animals Biological and medical sciences Choroid Hemorrhage - blood Choroid Hemorrhage - drug therapy Choroid Hemorrhage - pathology Dose-Response Relationship, Drug Eye Follow-Up Studies Medical sciences Original Paper · Travail original · Originalarbeit Pharmacology. Drug treatments Photoreceptor Cells - drug effects Photoreceptor Cells - pathology Plasminogen Activators - therapeutic use Rabbits Random Allocation Surgical Sponges Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use Treatment Outcome |
| title | Treatment of Suprachoroidal Hemorrhage with Tissue Plasminogen Activator |
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