The Progression of Alzheimer’s Disease from Limbic Regions to the Neocortex: Clinical, Radiological and Pathological Relationships
Alzheimer’s disease (AD) is characterised by the gradual accumulation of neurofibrillary pathology in selected regions of the brain. Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient’s cognitive performance as well as with medial tem...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 1999-03, Vol.10 (2), p.115-120 |
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| creator | Nagy, Zs Hindley, N.J. Braak, H. Braak, E. Yilmazer-Hanke, D.M. Schultz, C. Barnetson, L. King, E.M.-F. Jobst, K.A. Smith, A.D. |
| description | Alzheimer’s disease (AD) is characterised by the gradual accumulation of neurofibrillary pathology in selected regions of the brain. Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient’s cognitive performance as well as with medial temporal lobe atrophy on CT scans. There are also indications that progression through the pathological stages of AD is associated with decline in cognitive functions. The results of this study indicate that progression of disease, especially beyond the boundaries of the limbic regions, is associated with marked decline in the cognitive performance of patients suffering from AD. However the clinical manifestations of early pathological stages are not so well defined. We also found that the atrophy of the medial temporal lobe on CT scans is related to the progression of pathology. Atrophy is most apparent when the disease reaches its isocortical stages and is not marked in the limbic stages of the disease. The additive effect of pathologies co-existing with AD is apparent in reduced cognitive scores, while the atrophy of limbic structures, as measured on CT scans, seems to be mainly attributable to AD-related pathology. |
| doi_str_mv | 10.1159/000017111 |
| format | Article |
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Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient’s cognitive performance as well as with medial temporal lobe atrophy on CT scans. There are also indications that progression through the pathological stages of AD is associated with decline in cognitive functions. The results of this study indicate that progression of disease, especially beyond the boundaries of the limbic regions, is associated with marked decline in the cognitive performance of patients suffering from AD. However the clinical manifestations of early pathological stages are not so well defined. We also found that the atrophy of the medial temporal lobe on CT scans is related to the progression of pathology. Atrophy is most apparent when the disease reaches its isocortical stages and is not marked in the limbic stages of the disease. The additive effect of pathologies co-existing with AD is apparent in reduced cognitive scores, while the atrophy of limbic structures, as measured on CT scans, seems to be mainly attributable to AD-related pathology.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000017111</identifier><identifier>PMID: 10026385</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Biological and medical sciences ; Cognition ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Humans ; Limbic System - diagnostic imaging ; Limbic System - pathology ; Male ; Medical sciences ; Memory ; Neocortex - diagnostic imaging ; Neocortex - pathology ; Neurofibrillary Tangles - pathology ; Neurology ; Neuropsychological Tests ; Original Research Article ; Prospective Studies ; Severity of Illness Index ; Temporal Lobe - pathology ; Tomography, X-Ray Computed</subject><ispartof>Dementia and geriatric cognitive disorders, 1999-03, Vol.10 (2), p.115-120</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright S. 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Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient’s cognitive performance as well as with medial temporal lobe atrophy on CT scans. There are also indications that progression through the pathological stages of AD is associated with decline in cognitive functions. The results of this study indicate that progression of disease, especially beyond the boundaries of the limbic regions, is associated with marked decline in the cognitive performance of patients suffering from AD. However the clinical manifestations of early pathological stages are not so well defined. We also found that the atrophy of the medial temporal lobe on CT scans is related to the progression of pathology. Atrophy is most apparent when the disease reaches its isocortical stages and is not marked in the limbic stages of the disease. The additive effect of pathologies co-existing with AD is apparent in reduced cognitive scores, while the atrophy of limbic structures, as measured on CT scans, seems to be mainly attributable to AD-related pathology.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Limbic System - diagnostic imaging</topic><topic>Limbic System - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Neocortex - diagnostic imaging</topic><topic>Neocortex - pathology</topic><topic>Neurofibrillary Tangles - pathology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Original Research Article</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Temporal Lobe - pathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagy, Zs</creatorcontrib><creatorcontrib>Hindley, N.J.</creatorcontrib><creatorcontrib>Braak, H.</creatorcontrib><creatorcontrib>Braak, E.</creatorcontrib><creatorcontrib>Yilmazer-Hanke, D.M.</creatorcontrib><creatorcontrib>Schultz, C.</creatorcontrib><creatorcontrib>Barnetson, L.</creatorcontrib><creatorcontrib>King, E.M.-F.</creatorcontrib><creatorcontrib>Jobst, K.A.</creatorcontrib><creatorcontrib>Smith, A.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagy, Zs</au><au>Hindley, N.J.</au><au>Braak, H.</au><au>Braak, E.</au><au>Yilmazer-Hanke, D.M.</au><au>Schultz, C.</au><au>Barnetson, L.</au><au>King, E.M.-F.</au><au>Jobst, K.A.</au><au>Smith, A.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Progression of Alzheimer’s Disease from Limbic Regions to the Neocortex: Clinical, Radiological and Pathological Relationships</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>10</volume><issue>2</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Alzheimer’s disease (AD) is characterised by the gradual accumulation of neurofibrillary pathology in selected regions of the brain. Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient’s cognitive performance as well as with medial temporal lobe atrophy on CT scans. There are also indications that progression through the pathological stages of AD is associated with decline in cognitive functions. The results of this study indicate that progression of disease, especially beyond the boundaries of the limbic regions, is associated with marked decline in the cognitive performance of patients suffering from AD. However the clinical manifestations of early pathological stages are not so well defined. We also found that the atrophy of the medial temporal lobe on CT scans is related to the progression of pathology. Atrophy is most apparent when the disease reaches its isocortical stages and is not marked in the limbic stages of the disease. The additive effect of pathologies co-existing with AD is apparent in reduced cognitive scores, while the atrophy of limbic structures, as measured on CT scans, seems to be mainly attributable to AD-related pathology.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10026385</pmid><doi>10.1159/000017111</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1420-8008 |
| ispartof | Dementia and geriatric cognitive disorders, 1999-03, Vol.10 (2), p.115-120 |
| issn | 1420-8008 1421-9824 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer Disease - psychology Biological and medical sciences Cognition Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Humans Limbic System - diagnostic imaging Limbic System - pathology Male Medical sciences Memory Neocortex - diagnostic imaging Neocortex - pathology Neurofibrillary Tangles - pathology Neurology Neuropsychological Tests Original Research Article Prospective Studies Severity of Illness Index Temporal Lobe - pathology Tomography, X-Ray Computed |
| title | The Progression of Alzheimer’s Disease from Limbic Regions to the Neocortex: Clinical, Radiological and Pathological Relationships |
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