Adrenocortical Imprint in the Fetus of a Diabetic Gestation

Offspring of diabetics are at increased risk for diabetes as adults. As corticosteroids are intimately involved in glucose homeostasis, we investigated aspects of corticosteroid activity in the late gestation fetuses of control, moderately diabetic and insulin-controlled streptozotocin-induced diabe...

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Veröffentlicht in:	Biology of the neonate 1999-07, Vol.76 (1), p.44-54
Hauptverfasser:	Malee, Maureen P., Wu, Ke-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - embryology Adrenal Glands - embryology Aldosterone - blood Animals Biological and medical sciences Blood Glucose - analysis Corticosterone - blood Cytochrome P-450 CYP11B2 Cytochrome P-450 Enzyme System - genetics Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diseases of mother, fetus and pregnancy Female Fetus - metabolism Fetus - physiology Gynecology. Andrology. Obstetrics Hypoglycemic Agents - therapeutic use In Situ Hybridization Insulin - blood Insulin - therapeutic use Medical sciences Original Paper Pregnancy Pregnancy in Diabetics - blood Pregnancy in Diabetics - physiopathology Pregnancy. Fetus. Placenta Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Ribonucleases RNA, Messenger - metabolism Steroid Hydroxylases - genetics
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