Membranous Glomerulonephritis with Nephrotic Syndrome Associated with Chronic Lymphocytic Leukemia
A 66-year-old woman was admitted to our hospital for evaluation of edema of the extremities. Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staini...
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| Veröffentlicht in: | American journal of nephrology 2000-09, Vol.20 (5), p.402-407 |
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| container_title | American journal of nephrology |
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| creator | Yahata, Naoyuki Kawanishi, Yoshikazu Okabe, Seiichi Kimura, Yukihiko Okada, Tomonari Otani, Masako Shimizu, Tohru Nakao, Toshiyuki Ohyashiki, Kazuma |
| description | A 66-year-old woman was admitted to our hospital for evaluation of edema of the extremities. Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG) and the third component of complement in the glomerular basement membrane. Electron microscopy showed fibrillary deposits in the subepithelium. These findings indicated membranous glomerulonephritis (MGN). In addition, focal segmental sclerosis and interstitial lymphocytic infiltration were observed in the renal biopsy specimen. In CLL patients nephrotic syndrome occurs rarely. Even if the complication occurs, MGN is not frequent. Both diseases are suspected to occur in association with each other, and immunologic abnormality contributes to their coexistence. Although administration of prednisolone and endoxan improved leukocytosis, proteinuria was not sufficiently improved with combination therapy. |
| doi_str_mv | 10.1159/000013626 |
| format | Article |
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Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG) and the third component of complement in the glomerular basement membrane. Electron microscopy showed fibrillary deposits in the subepithelium. These findings indicated membranous glomerulonephritis (MGN). In addition, focal segmental sclerosis and interstitial lymphocytic infiltration were observed in the renal biopsy specimen. In CLL patients nephrotic syndrome occurs rarely. Even if the complication occurs, MGN is not frequent. Both diseases are suspected to occur in association with each other, and immunologic abnormality contributes to their coexistence. Although administration of prednisolone and endoxan improved leukocytosis, proteinuria was not sufficiently improved with combination therapy.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000013626</identifier><identifier>PMID: 11092999</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Basement Membrane - metabolism ; Biological and medical sciences ; Case Report ; Complement C3 - metabolism ; Female ; Fluorescent Antibody Technique ; Glomerulonephritis ; Glomerulonephritis, Membranous - complications ; Glomerulonephritis, Membranous - metabolism ; Glomerulonephritis, Membranous - pathology ; Glomerulosclerosis, Focal Segmental - complications ; Glomerulosclerosis, Focal Segmental - metabolism ; Glomerulosclerosis, Focal Segmental - pathology ; Humans ; Immunoglobulin G - metabolism ; Kidney - pathology ; Kidney Glomerulus - metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell - complications ; Lymphocytes - pathology ; Medical sciences ; Microscopy, Electron ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nephrotic Syndrome - complications</subject><ispartof>American journal of nephrology, 2000-09, Vol.20 (5), p.402-407</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Sep/Oct 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-6536fe39e31a92526c7ac87016a30fd18c1621b161b0507685959647058a95513</citedby><cites>FETCH-LOGICAL-c414t-6536fe39e31a92526c7ac87016a30fd18c1621b161b0507685959647058a95513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=798332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11092999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yahata, Naoyuki</creatorcontrib><creatorcontrib>Kawanishi, Yoshikazu</creatorcontrib><creatorcontrib>Okabe, Seiichi</creatorcontrib><creatorcontrib>Kimura, Yukihiko</creatorcontrib><creatorcontrib>Okada, Tomonari</creatorcontrib><creatorcontrib>Otani, Masako</creatorcontrib><creatorcontrib>Shimizu, Tohru</creatorcontrib><creatorcontrib>Nakao, Toshiyuki</creatorcontrib><creatorcontrib>Ohyashiki, Kazuma</creatorcontrib><title>Membranous Glomerulonephritis with Nephrotic Syndrome Associated with Chronic Lymphocytic Leukemia</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>A 66-year-old woman was admitted to our hospital for evaluation of edema of the extremities. Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG) and the third component of complement in the glomerular basement membrane. Electron microscopy showed fibrillary deposits in the subepithelium. These findings indicated membranous glomerulonephritis (MGN). In addition, focal segmental sclerosis and interstitial lymphocytic infiltration were observed in the renal biopsy specimen. In CLL patients nephrotic syndrome occurs rarely. Even if the complication occurs, MGN is not frequent. Both diseases are suspected to occur in association with each other, and immunologic abnormality contributes to their coexistence. Although administration of prednisolone and endoxan improved leukocytosis, proteinuria was not sufficiently improved with combination therapy.</description><subject>Aged</subject><subject>Basement Membrane - metabolism</subject><subject>Biological and medical sciences</subject><subject>Case Report</subject><subject>Complement C3 - metabolism</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis, Membranous - complications</subject><subject>Glomerulonephritis, Membranous - metabolism</subject><subject>Glomerulonephritis, Membranous - pathology</subject><subject>Glomerulosclerosis, Focal Segmental - complications</subject><subject>Glomerulosclerosis, Focal Segmental - metabolism</subject><subject>Glomerulosclerosis, Focal Segmental - pathology</subject><subject>Humans</subject><subject>Immunoglobulin G - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - complications</subject><subject>Lymphocytes - pathology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Nephrology. 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Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG) and the third component of complement in the glomerular basement membrane. Electron microscopy showed fibrillary deposits in the subepithelium. These findings indicated membranous glomerulonephritis (MGN). In addition, focal segmental sclerosis and interstitial lymphocytic infiltration were observed in the renal biopsy specimen. In CLL patients nephrotic syndrome occurs rarely. Even if the complication occurs, MGN is not frequent. Both diseases are suspected to occur in association with each other, and immunologic abnormality contributes to their coexistence. Although administration of prednisolone and endoxan improved leukocytosis, proteinuria was not sufficiently improved with combination therapy.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11092999</pmid><doi>10.1159/000013626</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of nephrology, 2000-09, Vol.20 (5), p.402-407 |
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| subjects | Aged Basement Membrane - metabolism Biological and medical sciences Case Report Complement C3 - metabolism Female Fluorescent Antibody Technique Glomerulonephritis Glomerulonephritis, Membranous - complications Glomerulonephritis, Membranous - metabolism Glomerulonephritis, Membranous - pathology Glomerulosclerosis, Focal Segmental - complications Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology Humans Immunoglobulin G - metabolism Kidney - pathology Kidney Glomerulus - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - complications Lymphocytes - pathology Medical sciences Microscopy, Electron Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrotic Syndrome - complications |
| title | Membranous Glomerulonephritis with Nephrotic Syndrome Associated with Chronic Lymphocytic Leukemia |
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