Effect of Glycemic Control and Vitamin E Supplementation on Total Glutathione Content in Non-Insulin-Dependent Diabetes mellitus

Thirty patients with non-insulin-dependent diabetes mellitus were selected for the study. 15 age-matched healthy volunteers served as controls. Serum malonaldehyde, total glutathione, and vitamin E levels were estimated before and after glycemic control and after 4 weeks of vitamin E supplementation...

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Veröffentlicht in:	Annals of nutrition and metabolism 2000-01, Vol.44 (1), p.11-13
Hauptverfasser:	Sharma, Anjali, Kharb, Simmi, Chugh, S.N., Kakkar, Rajesh, Singh, G.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Dietary Supplements Glutathione - blood Humans Malondialdehyde - blood Original Paper Oxidative Stress Vitamin E - administration & dosage Vitamin E - blood
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creator	Sharma, Anjali Kharb, Simmi Chugh, S.N. Kakkar, Rajesh Singh, G.P.
description	Thirty patients with non-insulin-dependent diabetes mellitus were selected for the study. 15 age-matched healthy volunteers served as controls. Serum malonaldehyde, total glutathione, and vitamin E levels were estimated before and after glycemic control and after 4 weeks of vitamin E supplementation. Both total glutathione and vitamin E levels increased after glycemic control and showed an increase after vitamin E supplementation. Malonaldehyde levels lowered after glycemic control, but remained higher than controls. Since vitamin E supplementation significantly decreased oxidative stress in the present study, it may play a role in reducing free-radical-induced oxidant injury in diabetes mellitus.
doi_str_mv	10.1159/000012815
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subjects	Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Dietary Supplements Glutathione - blood Humans Malondialdehyde - blood Original Paper Oxidative Stress Vitamin E - administration & dosage Vitamin E - blood
title	Effect of Glycemic Control and Vitamin E Supplementation on Total Glutathione Content in Non-Insulin-Dependent Diabetes mellitus
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