Circulating Levels of Carboxyterminal Propeptide of Type I Procollagen and Left Ventricular Remodeling after Myocardial Infarction
Alteration in myocardial collagen metabolism is an important factor in the progression of ventricular remodeling after myocardial infarction (MI). This study examined sequential changes in circulating levels of carboxyterminal propeptide of type I procollagen (PICP) as a collagen synthesis marker in...
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| Veröffentlicht in: | Cardiology 1999-01, Vol.91 (2), p.81-86 |
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| creator | Takino, Toshitake Nakamura, Motoyuki Hiramori, Katsuhiko |
| description | Alteration in myocardial collagen metabolism is an important factor in the progression of ventricular remodeling after myocardial infarction (MI). This study examined sequential changes in circulating levels of carboxyterminal propeptide of type I procollagen (PICP) as a collagen synthesis marker in order to assess the value of PICP for predicting the progression of left ventricular remodeling after MI. The study group comprised 20 patients with first MI undergoing reperfusion therapy. Peripheral blood samples were obtained on admission and serially up to 4 weeks after admission. Circulating levels of PICP and B-type natriuretic peptide (BNP), a tentative biochemical marker for the severity of MI, were measured by direct radioimmunoassay. Left ventricular end-diastolic volume index (EDVI) in acute and chronic phases were determined by left ventriculography, and changes (Δ) in EDVI were used as an index of left ventricular remodeling. Plasma PICP levels in the non-dilation group (< median ΔEDVI) showed no significant change. However, in the dilation group (> median ΔEDVI) PICP started to increase significantly 3 days after admission, peaking on day 14 (from 74 ± 6 to 104 ± 19 ng/ml, p < 0.05). ΔEDVI was significantly correlated with plasma PICP at 2 and 3 weeks, and with plasma BNP at 1, 2 and 3 weeks. Plasma PICP 2 weeks after MI was the only independent predictor of ΔEDVI (p < 0.001). These results suggest that an increase in plasma PICP levels 2 weeks after admission is a useful biochemical predictor of the progression of ventricular remodeling after MI. |
| doi_str_mv | 10.1159/000006884 |
| format | Article |
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This study examined sequential changes in circulating levels of carboxyterminal propeptide of type I procollagen (PICP) as a collagen synthesis marker in order to assess the value of PICP for predicting the progression of left ventricular remodeling after MI. The study group comprised 20 patients with first MI undergoing reperfusion therapy. Peripheral blood samples were obtained on admission and serially up to 4 weeks after admission. Circulating levels of PICP and B-type natriuretic peptide (BNP), a tentative biochemical marker for the severity of MI, were measured by direct radioimmunoassay. Left ventricular end-diastolic volume index (EDVI) in acute and chronic phases were determined by left ventriculography, and changes (Δ) in EDVI were used as an index of left ventricular remodeling. Plasma PICP levels in the non-dilation group (< median ΔEDVI) showed no significant change. However, in the dilation group (> median ΔEDVI) PICP started to increase significantly 3 days after admission, peaking on day 14 (from 74 ± 6 to 104 ± 19 ng/ml, p < 0.05). ΔEDVI was significantly correlated with plasma PICP at 2 and 3 weeks, and with plasma BNP at 1, 2 and 3 weeks. Plasma PICP 2 weeks after MI was the only independent predictor of ΔEDVI (p < 0.001). These results suggest that an increase in plasma PICP levels 2 weeks after admission is a useful biochemical predictor of the progression of ventricular remodeling after MI.</description><identifier>ISSN: 0008-6312</identifier><identifier>EISSN: 1421-9751</identifier><identifier>DOI: 10.1159/000006884</identifier><identifier>PMID: 10449877</identifier><identifier>CODEN: CAGYAO</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Coronary heart disease ; Female ; General Cardiology ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Peptide Fragments - biosynthesis ; Peptide Fragments - blood ; Predictive Value of Tests ; Procollagen - biosynthesis ; Procollagen - blood ; Prognosis ; Regression Analysis ; Sensitivity and Specificity ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Remodeling - physiology</subject><ispartof>Cardiology, 1999-01, Vol.91 (2), p.81-86</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. 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This study examined sequential changes in circulating levels of carboxyterminal propeptide of type I procollagen (PICP) as a collagen synthesis marker in order to assess the value of PICP for predicting the progression of left ventricular remodeling after MI. The study group comprised 20 patients with first MI undergoing reperfusion therapy. Peripheral blood samples were obtained on admission and serially up to 4 weeks after admission. Circulating levels of PICP and B-type natriuretic peptide (BNP), a tentative biochemical marker for the severity of MI, were measured by direct radioimmunoassay. Left ventricular end-diastolic volume index (EDVI) in acute and chronic phases were determined by left ventriculography, and changes (Δ) in EDVI were used as an index of left ventricular remodeling. Plasma PICP levels in the non-dilation group (< median ΔEDVI) showed no significant change. However, in the dilation group (> median ΔEDVI) PICP started to increase significantly 3 days after admission, peaking on day 14 (from 74 ± 6 to 104 ± 19 ng/ml, p < 0.05). ΔEDVI was significantly correlated with plasma PICP at 2 and 3 weeks, and with plasma BNP at 1, 2 and 3 weeks. Plasma PICP 2 weeks after MI was the only independent predictor of ΔEDVI (p < 0.001). These results suggest that an increase in plasma PICP levels 2 weeks after admission is a useful biochemical predictor of the progression of ventricular remodeling after MI.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. 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Vascular system</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>General Cardiology</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Peptide Fragments - biosynthesis</topic><topic>Peptide Fragments - blood</topic><topic>Predictive Value of Tests</topic><topic>Procollagen - biosynthesis</topic><topic>Procollagen - blood</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Sensitivity and Specificity</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Remodeling - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takino, Toshitake</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>Hiramori, Katsuhiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takino, Toshitake</au><au>Nakamura, Motoyuki</au><au>Hiramori, Katsuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Levels of Carboxyterminal Propeptide of Type I Procollagen and Left Ventricular Remodeling after Myocardial Infarction</atitle><jtitle>Cardiology</jtitle><addtitle>Cardiology</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>91</volume><issue>2</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0008-6312</issn><eissn>1421-9751</eissn><coden>CAGYAO</coden><abstract>Alteration in myocardial collagen metabolism is an important factor in the progression of ventricular remodeling after myocardial infarction (MI). This study examined sequential changes in circulating levels of carboxyterminal propeptide of type I procollagen (PICP) as a collagen synthesis marker in order to assess the value of PICP for predicting the progression of left ventricular remodeling after MI. The study group comprised 20 patients with first MI undergoing reperfusion therapy. Peripheral blood samples were obtained on admission and serially up to 4 weeks after admission. Circulating levels of PICP and B-type natriuretic peptide (BNP), a tentative biochemical marker for the severity of MI, were measured by direct radioimmunoassay. Left ventricular end-diastolic volume index (EDVI) in acute and chronic phases were determined by left ventriculography, and changes (Δ) in EDVI were used as an index of left ventricular remodeling. Plasma PICP levels in the non-dilation group (< median ΔEDVI) showed no significant change. However, in the dilation group (> median ΔEDVI) PICP started to increase significantly 3 days after admission, peaking on day 14 (from 74 ± 6 to 104 ± 19 ng/ml, p < 0.05). ΔEDVI was significantly correlated with plasma PICP at 2 and 3 weeks, and with plasma BNP at 1, 2 and 3 weeks. Plasma PICP 2 weeks after MI was the only independent predictor of ΔEDVI (p < 0.001). These results suggest that an increase in plasma PICP levels 2 weeks after admission is a useful biochemical predictor of the progression of ventricular remodeling after MI.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10449877</pmid><doi>10.1159/000006884</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cardiology, 1999-01, Vol.91 (2), p.81-86 |
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| subjects | Aged Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Coronary heart disease Female General Cardiology Heart Humans Male Medical sciences Middle Aged Myocardial Infarction - blood Peptide Fragments - biosynthesis Peptide Fragments - blood Predictive Value of Tests Procollagen - biosynthesis Procollagen - blood Prognosis Regression Analysis Sensitivity and Specificity Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling - physiology |
| title | Circulating Levels of Carboxyterminal Propeptide of Type I Procollagen and Left Ventricular Remodeling after Myocardial Infarction |
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