Abstract 2603: Subtype-specific ovarian cancer risk associated with SNPs in IL1A

As pathways of the immune system play an important role in multiple malignancies, we assessed the association between single-nucleotide polymorphisms (SNPs) in inflammation-related genes and risk of ovarian cancer in a multi-site case-control study. Using a custom array, we genotyped 930 epithelial...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-04, Vol.72 (8_Supplement), p.2603-2603
Hauptverfasser:	Charbonneau, Bridget, White, Kristin L., Schildkraut, Joellen M., Palmieri, Rachel T., Iversen, Ed, Berchuck, Andrew, Vierkant, Robert A., Rider, David N., Cicek, Mine S., Sutphen, Rebecca, Birrer, Michael J., Pharoah, Paul P.D., Song, Honglin, Tyrer, Jonathan, Gayther, Simon A., Ramus, Susan J., Wentzensen, Nicolas, Yang, Hannah P., Garcia-Closas, Montserrat, Phelan, Catherine M., Cunningham, Julie M., Fridley, Brooke L., Sellers, Thomas A., Goode, Ellen L.
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Sprache:	eng
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Zusammenfassung:	As pathways of the immune system play an important role in multiple malignancies, we assessed the association between single-nucleotide polymorphisms (SNPs) in inflammation-related genes and risk of ovarian cancer in a multi-site case-control study. Using a custom array, we genotyped 930 epithelial ovarian cancer cases and 1,037 controls for SNPs in ALOX12, ALOX15, ALOX5, CCL11, CCL2, CCL3, CCR3, CRP, CXCL16, IL10, IL15RA, IL18, IL1A, IL1B, IL1RN, IL4R, IL6, IL6R, IL7R, IL8RA, IL8RB, IL9, NOS3, PTGS1, PTGS2, TLR2, and TNF. After analysis by logistic regression, SNPs with p
ISSN:	0008-5472 1538-7445
DOI:	10.1158/1538-7445.AM2012-2603