Comparative Evaluation of Native and Liposomal Curcumin Against Acute Reproductive Toxicity Induced by Cadmium Chloride in Male Mice

Exposure to cadmium chloride (Cd) is linked to reproductive disorders. Curcumin (CUR), a traditional medicinal compound, has been considered for its therapeutic properties. The present study evaluated the antioxidant effects of CUR and liposomal CUR on Cd‐induced testicular toxicity. Mice were exposed to Cd (2.5 mg/kg as a single intraperitoneal dose), Cd + CUR at 50, 100, and 200 mg/kg, and Cd + liposomal CUR (15 mg/kg) orally for 7 days. At the end of the treatment period, histological studies, sperm parameters, oxidative stress parameters, and blood–testis barrier (BTB) integrity were performed. Cd‐induced histopathological deleterious changes in the testis and epididymis tissues increased BTB permeability. It caused a significant decrease in sperm count and viability ( p < 0.001), as well as an increase in sperm abnormality ( p < 0.001) and a reduction in the antioxidant activity of superoxide dismutase (SOD), glutathione (GSH) ( p < 0.001), and increased lipid peroxidation (LPO; p < 0.001) compared to the control group. Co‐treatment of CUR with Cd dose‐dependently and significantly attenuated Cd’s destructive effects on sperm and oxidative stress parameters at 50 mg/kg ( p < 0.01) and 100, 200 mg/kg ( p < 0.001). Although the liposomal form of CUR showed protective effects against some Cd‐induced changes, such as sperm viability and count ( p < 0.001), it did not significantly improve LPO and GSH levels. The results indicated that native CUR prevented Cd‐induced reproductive toxicity in male mice by suppressing oxidative injury, and there was no superior effect of liposomal CUR over native CUR.