Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats
Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100...
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| creator | Liu, Jing Yang, Chao Wu, Zhigui Pei, Jianguo Chen, Yao Huang, Xiao Gao, Sha Kan, Rui Zhang, Wenna Xie, Saisai Fu, Xiaomei |
| description | Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. Therefore, GFE can be a promising protective agent of colitis that deserves further investigation. |
| doi_str_mv | 10.1155/2021/9920379 |
| format | Article |
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The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. Therefore, GFE can be a promising protective agent of colitis that deserves further investigation.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/9920379</identifier><identifier>PMID: 34956390</identifier><language>eng</language><publisher>LONDON: Hindawi</publisher><subject>Acids ; Catheters ; Chinese medicine ; Colon ; Cytokines ; Ethanol ; Etiology ; Fruits ; Gardenia jasminoides ; IL-1β ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Integrative & Complementary Medicine ; Interleukin 6 ; Laboratory animals ; Life Sciences & Biomedicine ; Natural products ; Oral administration ; Science & Technology ; Software ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Ulcerative colitis</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.9920379-11, Article 9920379</ispartof><rights>Copyright © 2021 Jing Liu et al.</rights><rights>Copyright © 2021 Jing Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Jing Liu et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000865816000005</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c448t-83eaae08c554aa2fc092bbe5e4570d2ee7e3db2e999652a995d7ed8b157853b53</citedby><cites>FETCH-LOGICAL-c448t-83eaae08c554aa2fc092bbe5e4570d2ee7e3db2e999652a995d7ed8b157853b53</cites><orcidid>0000-0002-0343-4504 ; 0000-0002-6396-4160 ; 0000-0001-7389-1367 ; 0000-0001-9504-0547 ; 0000-0003-4032-6788 ; 0000-0002-7449-5363 ; 0000-0002-8274-0066 ; 0000-0001-5084-0612 ; 0000-0001-5580-7707 ; 0000-0002-2096-8321 ; 0000-0002-9409-3169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694976/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694976/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27928,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34956390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Feng, Yibin</contributor><contributor>Yibin Feng</contributor><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Wu, Zhigui</creatorcontrib><creatorcontrib>Pei, Jianguo</creatorcontrib><creatorcontrib>Chen, Yao</creatorcontrib><creatorcontrib>Huang, Xiao</creatorcontrib><creatorcontrib>Gao, Sha</creatorcontrib><creatorcontrib>Kan, Rui</creatorcontrib><creatorcontrib>Zhang, Wenna</creatorcontrib><creatorcontrib>Xie, Saisai</creatorcontrib><creatorcontrib>Fu, Xiaomei</creatorcontrib><title>Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats</title><title>Evidence-based complementary and alternative medicine</title><addtitle>EVID-BASED COMPL ALT</addtitle><addtitle>Evid Based Complement Alternat Med</addtitle><description>Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. 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Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><stitle>EVID-BASED COMPL ALT</stitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>9920379</spage><epage>11</epage><pages>9920379-11</pages><artnum>9920379</artnum><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. 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| subjects | Acids Catheters Chinese medicine Colon Cytokines Ethanol Etiology Fruits Gardenia jasminoides IL-1β Inflammation Inflammatory bowel disease Inflammatory bowel diseases Integrative & Complementary Medicine Interleukin 6 Laboratory animals Life Sciences & Biomedicine Natural products Oral administration Science & Technology Software Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis |
| title | Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats |
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