A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver

A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver

We clarified the hepatoprotective effect of Gentiana dahurica Fisch ethanol extract (GDEE) in our previous study, and we further revealed the mechanism with the help of metabolomics technology in this study. The livers from Control group, Alcohol group, and Alcohol + GDEE group were analyzed by meta...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2021-06, Vol.2021, p.1-7, Article 5569538
Hauptverfasser: Cao, Houkang, Guo, Yanxiu, Jin, Ling
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Amino acids
Correlation analysis
Data analysis
Ethanol
Gentiana
Glucose metabolism
High-performance liquid chromatography
Integrative & Complementary Medicine
Life Sciences & Biomedicine
Lipid metabolism
Liver diseases
Mass spectroscopy
Metabolism
Metabolites
Metabolomics
Principal components analysis
Quality control
Science & Technology
Software
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Zusammenfassung:We clarified the hepatoprotective effect of Gentiana dahurica Fisch ethanol extract (GDEE) in our previous study, and we further revealed the mechanism with the help of metabolomics technology in this study. The livers from Control group, Alcohol group, and Alcohol + GDEE group were analyzed by metabolomics. The metabolites in the liver were separated by ultra-high-performance liquid chromatography (UHPLC) and were tentatively identified using mass spectrometry (MS)/MS analysis. Differential metabolites were defined with VIP > 1 and P
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/5569538