Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients
Purpose. Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the co...
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| Veröffentlicht in: | BioMed research international 2020, Vol.2020 (2020), p.1-8, Article 9152140 |
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| creator | Li, Zhanfei Bai, Xiangjun Liu, Xinghua Dong, Xijie Zheng, Qiang Liu, Qinxin Liu, Yukun Wang, Yuchang Gao, Wei |
| description | Purpose. Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the correlation of PBMC pyroptosis with the severity and the mortality of septic patients. Methods. 128 trauma-induced patients with sepsis were enrolled in this prospective cohort study. Blood samples were collected, and PBMC pyroptosis was measured by flow cytometry within 24 hours after sepsis was diagnosed. Results. Percentage of PBMC pyroptosis was positively correlated with the acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score (all P14.17%) and increased risk of the 28-day mortality (hazard ratio=1.234, 95% CI, 1.014–1.502). Conclusion. The percentage of PBMC pyroptosis increases in septic patients, and the increased percentage of PBMC pyroptosis is associated with the severity of sepsis and the 28-day mortality of patients with sepsis. |
| doi_str_mv | 10.1155/2020/9152140 |
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Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the correlation of PBMC pyroptosis with the severity and the mortality of septic patients. Methods. 128 trauma-induced patients with sepsis were enrolled in this prospective cohort study. Blood samples were collected, and PBMC pyroptosis was measured by flow cytometry within 24 hours after sepsis was diagnosed. Results. Percentage of PBMC pyroptosis was positively correlated with the acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score (all P<0.01). The area under the curve (AUC) for the percentage of PBMC pyroptosis on a receiver operating characteristic curve was 0.79 (95% confidence interval (CI), 0.68–0.90). A Cox proportional hazard model identified an association between an increased percentage of PBMC pyroptosis (>14.17%) and increased risk of the 28-day mortality (hazard ratio=1.234, 95% CI, 1.014–1.502). Conclusion. The percentage of PBMC pyroptosis increases in septic patients, and the increased percentage of PBMC pyroptosis is associated with the severity of sepsis and the 28-day mortality of patients with sepsis.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/9152140</identifier><identifier>PMID: 32258157</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Abdomen ; Adult ; Age ; Apoptosis ; Bacterial infections ; Biotechnology & Applied Microbiology ; Blood ; Caspase 1 - blood ; Caspase-1 ; China ; Confidence intervals ; Disease ; Ethylenediaminetetraacetic acid ; Evaluation ; Female ; Flow cytometry ; Health hazards ; Humans ; Infection ; Infections ; Inflammation ; Inflammatory diseases ; Laboratories ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - metabolism ; Life Sciences & Biomedicine ; Male ; Medical prognosis ; Medical research ; Medicine, Experimental ; Medicine, Research & Experimental ; Middle Aged ; Mortality ; Patient outcomes ; Peripheral blood mononuclear cells ; Prospective Studies ; Pyroptosis ; Research & Experimental Medicine ; Science & Technology ; Sepsis ; Sepsis - blood ; Sepsis - mortality ; Severity of Illness Index ; Statistical models ; Studies ; Trauma ; Variance analysis</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-8, Article 9152140</ispartof><rights>Copyright © 2020 Yuchang Wang et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Yuchang Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Yuchang Wang et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>31</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000522222400005</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c499t-268194cc2ca472388f6644bf932600b1fb688c79ff22898c30292ad14c6dfa4c3</citedby><cites>FETCH-LOGICAL-c499t-268194cc2ca472388f6644bf932600b1fb688c79ff22898c30292ad14c6dfa4c3</cites><orcidid>0000-0002-7916-0992 ; 0000-0003-0947-9823</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066402/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066402/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27927,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32258157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Braun, Rudolf K.</contributor><contributor>Rudolf K Braun</contributor><creatorcontrib>Li, Zhanfei</creatorcontrib><creatorcontrib>Bai, Xiangjun</creatorcontrib><creatorcontrib>Liu, Xinghua</creatorcontrib><creatorcontrib>Dong, Xijie</creatorcontrib><creatorcontrib>Zheng, Qiang</creatorcontrib><creatorcontrib>Liu, Qinxin</creatorcontrib><creatorcontrib>Liu, Yukun</creatorcontrib><creatorcontrib>Wang, Yuchang</creatorcontrib><creatorcontrib>Gao, Wei</creatorcontrib><title>Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients</title><title>BioMed research international</title><addtitle>BIOMED RES INT</addtitle><addtitle>Biomed Res Int</addtitle><description>Purpose. Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the correlation of PBMC pyroptosis with the severity and the mortality of septic patients. Methods. 128 trauma-induced patients with sepsis were enrolled in this prospective cohort study. Blood samples were collected, and PBMC pyroptosis was measured by flow cytometry within 24 hours after sepsis was diagnosed. Results. Percentage of PBMC pyroptosis was positively correlated with the acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score (all P<0.01). The area under the curve (AUC) for the percentage of PBMC pyroptosis on a receiver operating characteristic curve was 0.79 (95% confidence interval (CI), 0.68–0.90). A Cox proportional hazard model identified an association between an increased percentage of PBMC pyroptosis (>14.17%) and increased risk of the 28-day mortality (hazard ratio=1.234, 95% CI, 1.014–1.502). Conclusion. The percentage of PBMC pyroptosis increases in septic patients, and the increased percentage of PBMC pyroptosis is associated with the severity of sepsis and the 28-day mortality of patients with sepsis.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Age</subject><subject>Apoptosis</subject><subject>Bacterial infections</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Blood</subject><subject>Caspase 1 - blood</subject><subject>Caspase-1</subject><subject>China</subject><subject>Confidence intervals</subject><subject>Disease</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Evaluation</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Health hazards</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Laboratories</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Medicine, Research & Experimental</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Peripheral blood mononuclear cells</subject><subject>Prospective Studies</subject><subject>Pyroptosis</subject><subject>Research & Experimental Medicine</subject><subject>Science & Technology</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - mortality</subject><subject>Severity of Illness Index</subject><subject>Statistical models</subject><subject>Studies</subject><subject>Trauma</subject><subject>Variance analysis</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhiMEotXSG2dkiQsShPorjn1BWsJXpSJWKpwtx7G7rrJ2iJ2u9gfwv3G0yy5wqi-25WfemfG8RfEcwbcIVdUlhhheClRhROGj4hwTREuGKHp8PBNyVlzEeAfz4ohBwZ4WZwTjiqOqPi9-NSoOKpoSlR_MYHxnfAKr3RiGFKKLIFiwMqMb1mZUPXjfh9CBr8EHP-neqBE0pu8juIpgGWPQTiXTga1La5DWBtyY-xybdkD5OWpMqp9vWfPGDMlpsFLJ5YTxWfHEqj6ai8O-KH58-vi9-VJef_t81SyvS02FSCVmHAmqNdaK1phwbhmjtLWCYAZhi2zLONe1sBZjLrgmEAusOkQ166yimiyKd3vdYWo3ptM5d25LDqPbqHEng3Ly3xfv1vI23Msa5kwQZ4FXB4Ex_JxMTHLjos5_oLwJU5S5qJpVTOR_XxQv_0PvwjT63F6magohI6Q6UbeqN9J5G3JePYvKJcOUcUGRyNSbPaXHEONo7LFkBOVsBDkbQR6MkPEXf7d5hP-MPQN8D2xNG2zUeQjaHLHslArPi86mqRqX8piCb8LkUw59_fDQE712vlNb98C6TWaMVScakVoISH4DrDPkog</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Li, Zhanfei</creator><creator>Bai, Xiangjun</creator><creator>Liu, Xinghua</creator><creator>Dong, Xijie</creator><creator>Zheng, Qiang</creator><creator>Liu, Qinxin</creator><creator>Liu, Yukun</creator><creator>Wang, Yuchang</creator><creator>Gao, Wei</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Publishing Group</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7916-0992</orcidid><orcidid>https://orcid.org/0000-0003-0947-9823</orcidid></search><sort><creationdate>2020</creationdate><title>Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients</title><author>Li, Zhanfei ; Bai, Xiangjun ; Liu, Xinghua ; Dong, Xijie ; Zheng, Qiang ; Liu, Qinxin ; Liu, Yukun ; Wang, Yuchang ; Gao, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-268194cc2ca472388f6644bf932600b1fb688c79ff22898c30292ad14c6dfa4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Age</topic><topic>Apoptosis</topic><topic>Bacterial infections</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Blood</topic><topic>Caspase 1 - blood</topic><topic>Caspase-1</topic><topic>China</topic><topic>Confidence intervals</topic><topic>Disease</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Evaluation</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Health hazards</topic><topic>Humans</topic><topic>Infection</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Laboratories</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Medicine, Research & Experimental</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patient outcomes</topic><topic>Peripheral blood mononuclear cells</topic><topic>Prospective Studies</topic><topic>Pyroptosis</topic><topic>Research & Experimental Medicine</topic><topic>Science & Technology</topic><topic>Sepsis</topic><topic>Sepsis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhanfei</au><au>Bai, Xiangjun</au><au>Liu, Xinghua</au><au>Dong, Xijie</au><au>Zheng, Qiang</au><au>Liu, Qinxin</au><au>Liu, Yukun</au><au>Wang, Yuchang</au><au>Gao, Wei</au><au>Braun, Rudolf K.</au><au>Rudolf K Braun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients</atitle><jtitle>BioMed research international</jtitle><stitle>BIOMED RES INT</stitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><artnum>9152140</artnum><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Purpose. Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the correlation of PBMC pyroptosis with the severity and the mortality of septic patients. Methods. 128 trauma-induced patients with sepsis were enrolled in this prospective cohort study. Blood samples were collected, and PBMC pyroptosis was measured by flow cytometry within 24 hours after sepsis was diagnosed. Results. Percentage of PBMC pyroptosis was positively correlated with the acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score (all P<0.01). The area under the curve (AUC) for the percentage of PBMC pyroptosis on a receiver operating characteristic curve was 0.79 (95% confidence interval (CI), 0.68–0.90). A Cox proportional hazard model identified an association between an increased percentage of PBMC pyroptosis (>14.17%) and increased risk of the 28-day mortality (hazard ratio=1.234, 95% CI, 1.014–1.502). Conclusion. The percentage of PBMC pyroptosis increases in septic patients, and the increased percentage of PBMC pyroptosis is associated with the severity of sepsis and the 28-day mortality of patients with sepsis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32258157</pmid><doi>10.1155/2020/9152140</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7916-0992</orcidid><orcidid>https://orcid.org/0000-0003-0947-9823</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Adult Age Apoptosis Bacterial infections Biotechnology & Applied Microbiology Blood Caspase 1 - blood Caspase-1 China Confidence intervals Disease Ethylenediaminetetraacetic acid Evaluation Female Flow cytometry Health hazards Humans Infection Infections Inflammation Inflammatory diseases Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Life Sciences & Biomedicine Male Medical prognosis Medical research Medicine, Experimental Medicine, Research & Experimental Middle Aged Mortality Patient outcomes Peripheral blood mononuclear cells Prospective Studies Pyroptosis Research & Experimental Medicine Science & Technology Sepsis Sepsis - blood Sepsis - mortality Severity of Illness Index Statistical models Studies Trauma Variance analysis |
| title | Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients |
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