The Use of Carbon Quantum Dot as Alternative of Stannous Chloride Application in Radiopharmaceutical Kits

The Use of Carbon Quantum Dot as Alternative of Stannous Chloride Application in Radiopharmaceutical Kits

Even today, technetium-99m is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetium-99m make it suitable as an available radionuclide in many centers. In this study, we examined the potential of CQD as a reducing agent in the MDP kit. Cit...

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Veröffentlicht in:Contrast media and molecular imaging 2020-11, Vol.2020 (2020), p.1-11
Hauptverfasser: Ardestani, Mehdi Shafiee, Alikhani, Zahra, Mirzaei, Mehdi, Etemadzade, Maziyar, Seyedhamzeh, Mohammad, Yadegari, Sina, Najdian, Atena, Ghoreishi, Seyedeh Masoumeh, Hadadian, Shahin
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container_end_page 11
container_issue 2020
container_start_page 1
container_title Contrast media and molecular imaging
container_volume 2020
creator Ardestani, Mehdi Shafiee
Alikhani, Zahra
Mirzaei, Mehdi
Etemadzade, Maziyar
Seyedhamzeh, Mohammad
Yadegari, Sina
Najdian, Atena
Ghoreishi, Seyedeh Masoumeh
Hadadian, Shahin
description Even today, technetium-99m is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetium-99m make it suitable as an available radionuclide in many centers. In this study, we examined the potential of CQD as a reducing agent in the MDP kit. Citric acid-derived CQD was synthesized and confirmed by FT-IR, TEM, UV-Vis, XPS, and surface analysis. No cytotoxicity was observed by the MTT assay. They were reducing properties of the CQD confirmed by fluorescence microscopy. The MDP kit is prepared by evaluating different parameters that affect the radiolabeling yield, including ligand, time, and CQD. The optimum amount of each parameter is obtained by Box–Behnken software. Finally, fluorescent spectroscopy, SPECT imaging, and biodistribution study showed that CQD reduces technetium-99m. Accumulation of radiotracer in the femur showed that CQD could be used in a radiopharmaceutical kit.
doi_str_mv 10.1155/2020/4742158
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title The Use of Carbon Quantum Dot as Alternative of Stannous Chloride Application in Radiopharmaceutical Kits
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