Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor- β 3 Signaling Pathway

We have identified a gene YOD1 encoding deubiquitinating enzyme (DUB) responsible for nonsyndromic cleft lip with or without cleft palate (NSCL/P). We aimed to determine the effects of YOD1 RNA interference (RNAi) on cell proliferation and migration, playing an important role in lip and palate forma...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018, p.6254308-8
Hauptverfasser:	Zhou, Xiao-Long, Chen, Gang, Li, Meng-Xue, Wang, Heng-Xue, Hong, Jia-Wei, Shen, Jun-Yu, Wang, Qi, Ge, Xing, Ding, Zhen, Xu, Li-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Movement Cell Proliferation Cleft Lip - genetics Cleft Lip - metabolism Cleft Lip - pathology Cleft Palate - genetics Cleft Palate - metabolism Cleft Palate - pathology Endopeptidases - biosynthesis Endopeptidases - genetics Humans Keratinocytes - metabolism Keratinocytes - pathology Mouth - metabolism Mouth - pathology RNA Interference Signal Transduction Thiolester Hydrolases - biosynthesis Thiolester Hydrolases - genetics Transforming Growth Factor beta3 - genetics Transforming Growth Factor beta3 - metabolism
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